Cited by 674Growth Hormone and Insulin-like Growth FactorsSperm and Testicular FunctionHypothalamic control of reproductive hormones

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Effects of an Igf1 Gene Null Mutation on Mouse Reproduction

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Baker, J, Hardy, M P, Zhou, J, Bondy, C, Lupu, F, Bellvé, A R, Efstratiadis, A·1996·Molecular Endocrinology

DOI 10.1210/mend.10.7.8813730

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Abstract

Both sexes of adult mice homozygous for a targeted mutation of the Igf1 gene, encoding insulin-like growth factor 1, are infertile dwarfs (approximately 30% of normal size). The testes are reduced in size less than expected from the degree of dwarfism but sustain spermatogenesis only at 18% of the normal level. The epididymides are overall nearly allometric to the reduced body weight, but the distal regions of the duct, vas deferens, seminal vesicles, and prostate are vestigial. Despite the mutational impact on the epididymis, capacitated sperm are able to fertilize wild type eggs in vitro. It is hypothesized that the infertility of male mutants is caused by failure of androgenization resulting in absence of mating behavior, due to drastically reduced levels of serum testosterone (18% of normal). This hormonal deficiency was correlated with an ultrastructural analysis of mutant Leydig cells revealing a significant developmental delay, while assays in organ culture showed that the basal and LH-stimulated production of testosterone by testicular parenchyma is reduced in comparison with wild type controls. The female mutants fail to ovulate even after administration of gonadotropins, which is apparently the primary cause of their infertility, and possess an infantile uterus that exhibits a dramatic hypoplasia especially in the myometrium. The phenotypic manifestations of the mutation were correlated with the localization of transcripts for insulin-like growth factor I and its cognate receptor in wild type reproductive tissues by in situ hybridization.

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Insulin-Like Growth Factors and Their Binding Proteins: Biological Actions*
Jones, J. I. W., & Clemmons, D. R. (1995) · Endocrine Reviews · doi:10.1210/edrv-16-1-3 · Cited by 4,488
Insulin-like growth factors and their binding proteins: biological actions
Jones, J. I. (1995) · Endocrine Reviews · doi:10.1210/er.16.1.3 · Cited by 2,060
Manipulating the Mouse Embryo: A Laboratory Manual
Behringer, R. R., Gertsenstein, M., Nagy, K. V., & Nagy, A. (2002) · Cited by 2,046
Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene.
Lubahn, D. B., Moyer, J. S., GOLDING, T. S., Couse, J. F., Korach, K. S., & Smithies, O. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.23.11162 · Cited by 1,902
Parental imprinting of the mouse insulin-like growth factor II gene
DeChiara, T. M., Robertson, E. J., & Efstratiadis, A. (1991) · Cell · doi:10.1016/0092-8674(91)90513-x · Cited by 1,804
A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting
DeChiara, T. M., Efstratiadis, A., & Robertsen, E. J. (1990) · Nature · doi:10.1038/345078a0 · Cited by 1,663
Insights from the study of animals lacking functional estrogen receptor
Korach, K. S. (1994) · Science · doi:10.1126/science.7985022 · Cited by 574
[9] Culture of preimplantation embryos
Lawitts, J. A., & Biggers, J. D. (1993) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(93)25012-q · Cited by 570
Gonadotrophin-releasing hormone deficiency in a mutant mouse with hypogonadism
Cattanach, B. M., IDDON, C. A., Charlton, H. M., CHIAPPA, S. A., & Fink, G. (1977) · Nature · doi:10.1038/269338a0 · Cited by 567
Insulin-Like Growth Factors and Ovarian Follicular Development*
Giudice, L. C. (1992) · Endocrine Reviews · doi:10.1210/edrv-13-4-641 · Cited by 521

Flagged first, then by citations

Show all 45 references

Research works printed but not linked: 5

Scanes CG, Daughaday WH 1995 Growth hormone action: growth. In: Harvey S, Scanes CG, Daughaday WH (eds) Growth Hormone. CRC Press, Boca Raton, FL, pp 351-369
Adashi EY 1993 The intraovarian insulin-like growth fac- tor system. In: Adashi EY, Leung PCK (eds) The Ovary. Raven Press, New York, pp 319-335
Magoffin DA, Erickson GF 1994 Control systems of theta-interstitial cells. In: Findlay JK (ed) Molecular Bi- ology of the Female Reproductive System. Academic Press, New York, pp 39-65
van Buul-Offers S 1983 Hormonal and other inherited growth disturbances in mice with special reference to the Snell dwarf mouse. A review. Acta Endocrinol (Copenh) 103:1-47
Camper SA, Saunders TL, Katz RW, Reeves RH 1990 The Pit-l transcription factor gene is a candidate for the murine Snell dwarf mutation. Genomics 8:586-590

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Authors: Baker, J., Hardy, M. P., Zhou, J., Bondy, C., Lupu, F., Bellvé, A. R., & Efstratiadis, A.
Affiliations: Columbia University (US)
ORCID: Baker, J
Hardy, M P
Zhou, J
Lupu, F
Venue: Molecular Endocrinology
Publisher: The Endocrine Society
Published: 1996-07
Volume: 10
Issue: 7
Pages: 903-918
ISSN: 0888-8809 (ISSN-L)
1944-9917
DOI: 10.1210/mend.10.7.8813730
OpenAlex: W2065752045
Cited by: 674
References: 45
Citations by year: 2026: 2 · 2025: 8 · 2024: 11 · 2023: 18 · 2022: 19 · 2021: 24 · 2020: 29 · 2019: 20 · 2018: 29 · 2017: 19 · 2016: 20 · 2015: 20 · 2014: 23 · 2013: 23 · 2012: 16
FWCI: 19.42
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Molecular Endocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01hd029010-03, 5r01hd028342-04)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-29010, HD-28342, HD32588)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords: insulin-like growth factor I, male infertility, dwarfism, spermatogenesis, Leydig cell development, androgen deficiency, androgenization, epididymis, female infertility, ovulation, myometrium, gonadotropin resistance, IGF-1 receptor, reproductive tract development
MeSH terms: Animals, Epididymis, Female, Infertility, Insulin-Like Growth Factor I, Male, Mice, Mutant Strains, Mutation, Organ Size, Ovary, Reproduction, Sperm Motility, Testis, Testosterone, Uterus, Gene Expression Regulation, Developmental, Mice

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Effects of an Igf1 Gene Null Mutation on Mouse Reproduction

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