The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Effects of an Igf1 Gene Null Mutation on Mouse Reproduction
Open accessAbstract
Both sexes of adult mice homozygous for a targeted mutation of the Igf1 gene, encoding insulin-like growth factor 1, are infertile dwarfs (approximately 30% of normal size). The testes are reduced in size less than expected from the degree of dwarfism but sustain spermatogenesis only at 18% of the normal level. The epididymides are overall nearly allometric to the reduced body weight, but the distal regions of the duct, vas deferens, seminal vesicles, and prostate are vestigial. Despite the mutational impact on the epididymis, capacitated sperm are able to fertilize wild type eggs in vitro. It is hypothesized that the infertility of male mutants is caused by failure of androgenization resulting in absence of mating behavior, due to drastically reduced levels of serum testosterone (18% of normal). This hormonal deficiency was correlated with an ultrastructural analysis of mutant Leydig cells revealing a significant developmental delay, while assays in organ culture showed that the basal and LH-stimulated production of testosterone by testicular parenchyma is reduced in comparison with wild type controls. The female mutants fail to ovulate even after administration of gonadotropins, which is apparently the primary cause of their infertility, and possess an infantile uterus that exhibits a dramatic hypoplasia especially in the myometrium. The phenotypic manifestations of the mutation were correlated with the localization of transcripts for insulin-like growth factor I and its cognate receptor in wild type reproductive tissues by in situ hybridization.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In IGF-1 gene null, –/– mutant mice (10), the testes, epididymides duct, vas deferens, seminal vesicles, and prostate are vestigial, leading to a low spermatogenesis rate at 18% of the normal level.”
From Growth Hormone Is Beneficial for Induction of Spermatogenesis in Adult Patients With Congenital Combined Pituitary Hormone Deficiency (2022) · cites this paper as [10]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Insulin-Like Growth Factors and Their Binding Proteins: Biological Actions*
Jones, J. I. W., & Clemmons, D. R. (1995) · Endocrine Reviews · doi:10.1210/edrv-16-1-3 · Cited by 4,488
Insulin-like growth factors and their binding proteins: biological actions
Jones, J. I. (1995) · Endocrine Reviews · doi:10.1210/er.16.1.3 · Cited by 2,060
Manipulating the Mouse Embryo: A Laboratory Manual
Behringer, R. R., Gertsenstein, M., Nagy, K. V., & Nagy, A. (2002) · Cited by 2,046
Lubahn, D. B., Moyer, J. S., GOLDING, T. S., Couse, J. F., Korach, K. S., & Smithies, O. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.23.11162 · Cited by 1,902
Parental imprinting of the mouse insulin-like growth factor II gene
DeChiara, T. M., Robertson, E. J., & Efstratiadis, A. (1991) · Cell · doi:10.1016/0092-8674(91)90513-x · Cited by 1,804
DeChiara, T. M., Efstratiadis, A., & Robertsen, E. J. (1990) · Nature · doi:10.1038/345078a0 · Cited by 1,663
Insights from the study of animals lacking functional estrogen receptor
Korach, K. S. (1994) · Science · doi:10.1126/science.7985022 · Cited by 574
[9] Culture of preimplantation embryos
Lawitts, J. A., & Biggers, J. D. (1993) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(93)25012-q · Cited by 570
Gonadotrophin-releasing hormone deficiency in a mutant mouse with hypogonadism
Cattanach, B. M., IDDON, C. A., Charlton, H. M., CHIAPPA, S. A., & Fink, G. (1977) · Nature · doi:10.1038/269338a0 · Cited by 567
Insulin-Like Growth Factors and Ovarian Follicular Development*
Giudice, L. C. (1992) · Endocrine Reviews · doi:10.1210/edrv-13-4-641 · Cited by 521
Research works printed but not linked: 5
- Scanes CG, Daughaday WH 1995 Growth hormone action: growth. In: Harvey S, Scanes CG, Daughaday WH (eds) Growth Hormone. CRC Press, Boca Raton, FL, pp 351-369
- Adashi EY 1993 The intraovarian insulin-like growth fac- tor system. In: Adashi EY, Leung PCK (eds) The Ovary. Raven Press, New York, pp 319-335
- Magoffin DA, Erickson GF 1994 Control systems of theta-interstitial cells. In: Findlay JK (ed) Molecular Bi- ology of the Female Reproductive System. Academic Press, New York, pp 39-65
- van Buul-Offers S 1983 Hormonal and other inherited growth disturbances in mice with special reference to the Snell dwarf mouse. A review. Acta Endocrinol (Copenh) 103:1-47
- Camper SA, Saunders TL, Katz RW, Reeves RH 1990 The Pit-l transcription factor gene is a candidate for the murine Snell dwarf mutation. Genomics 8:586-590
Cited by
Sorted by citations
Items 601–671 of 671
Hughes, S. B., Quan, M., Guthrie, A. J., & Schulman, M. L. (2013) · Onderstepoort Journal of Veterinary Research · doi:10.4102/ojvr.v80i1.402 · Cited by 1
Yılmaz, A. (2003) · OhioLink ETD Center (Ohio Library and Information Network) · Cited by 1
Transgenic Mouse Models in the Study of Ovarian Function
Rodriguez, A., Rydze, R. T., Briley, S. M., & Pangas, S. A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813209-8.00018-2 · Cited by 1
Al-Saaidi, J. A., Salih, M., & Al-Ali, A. H. (2017) · AL-QADISIYAH MEDICAL JOURNAL · doi:10.28922/qmj.2014.10.17.11-27 · Cited by 1
Fetal Leydig Cells: Formation, Properties, Functions, and Fate
Estermann, M. A., Huang, C. J., & Yao, H. H. (2025) · Springer eBooks · doi:10.1007/978-3-031-96376-6_2 · Cited by 1
INFLUENCIA DEL ESPESOR DE GRASA DORSAL EN EL DESEMPEÑO REPRODUCTIVO DE LA CERDA
Valdez, J. M. R., Espinoza-Aguirre, L. F., Gómez, I. P., Loera, J. J. P., Valdez, A. M. R., & Romo-Rubio, J. A. (2025) · Revista Contemporânea · doi:10.56083/rcv5n9-087 · Cited by 1
The Rise and Fall of Oogonial Stem Cells Within the Historical Context of Adult Stem Cells
Nayak, S. R., Ren, Y., & Rajkovic, A. (2016) · Springer eBooks · doi:10.1007/978-3-319-22491-6_11 · Cited by 1
The role of IGF3 in zebrafish spermatogenesis
Buitelaar, M. G. (2013) · Utrecht University Repository (Utrecht University) · Cited by 1
Insulin-Like Growth Factor Control of Growth
Chernausek, S. D. (1999) · Humana Press eBooks · doi:10.1007/978-1-59259-697-3_2 · Cited by 1
Lindeberg, M. (2008) · Figshare · Cited by 1
Wang, Q. (2013) · uO Research (University of Ottawa) · doi:10.20381/ruor-2980 · Cited by 1
Non-Steroidal Signal Molecules in Spermatogenesis
Gupta, G. S. (2005) · Springer eBooks · doi:10.1007/0-387-27655-6_3 · Cited by 1
Dixon, D., Nikitin, A. Y., & Mahler, J. F. (2021) · doi:10.1002/9781119624608.ch19 · Cited by 1
Uterine ERBB3 signaling is critical to cultivate stromal environment for functional gland branchingPreprint
Li, B., Dewar, A., Dey, S. K., & Sun, X. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.16.682855 · Cited by 1
Nutrition and the IGF System in Reproduction
Simmen, F. A., Kwak, I., Blum, J. L., & Simmen, R. C. M. (2004) · Humana Press eBooks · doi:10.1007/978-1-59259-795-6_8 · Cited by 1
Closset, J., & Reiter, É. (2003) · Elsevier eBooks · doi:10.1016/b978-012124546-7/50711-7 · Cited by 1
Mouse Models to Study the Pituitary-Testis Interplay Leading to Regulated Gene Expression
Borrelli, E., Kumar, T. R., & Sassone‐Corsi, P. (2001) · Humana Press eBooks · doi:10.1007/978-1-59259-102-2_5
Fertilidad femenina: lo que todo urólogo debe conocer
Robins, J. C., & Carson, S. A. (2008) · Clínicas urológicas de Norteamérica
Regulation of cholesterol intake by the corpus luteum
Miranda, L. (2010) · doi:10.71781/3695
Regulation of human ovarian folliculogenesis in vitro
Carlsson, I. B. (2008) · Figshare
Gougeon, A. (2000) · Springer eBooks · doi:10.1007/978-0-387-21508-2_2
Burnicka-Turek, O. (2009) · eDiss (Georg-August-Universität Göttingen)
Early life programming of adult Leydig cell function
Kilcoyne, K. R., Smith, L. B., Jobling, M. S., McKinnell, C., Macpherson, S., van, D. D. S., De, G. K., Verhoeven, G., Anderson, R. A., & Sharpe, R. M. (2014) · Reproduction Abstracts · doi:10.1530/repabs.1.p175
Transgenic Models to Study Reproduction, Oncogenesis, and Development
Elvin, J. A., & Matzuk, M. M. (2000) · Springer eBooks · doi:10.1007/978-0-387-21628-7_21
The genetic basis of impaired spermatogenesis and male infertility
Rocha, D., & Affara, N. A. (2000) · Current Obstetrics and Gynaecology · doi:10.1054/cuog.2000.0125
Miskova, A., Pilmane, M., & Rezeberga, D. (2012) · Papers on Anthropology · doi:10.12697/poa.2011.20.27
Physiologie und Pathologie des Geburtsbeginns
Schneider, H., Husslein, P.-W., & Schneider, K. T. M. (2011) · Springer eBooks · doi:10.1007/978-3-642-12974-2_23
Drion, P. V., Szenci, O., Ectors, F., Wirth, D., Perényi, Z., Muller, P., & Beckers, J. (2003) · Acta Veterinaria Hungarica · doi:10.1556/avet.51.2003.3.11
LeRoith, D., Blakesley, V. A., & Werner, H. (1999) · Comprehensive physiology · doi:10.1002/cphy.cp070520
Growth Hormone Receptor Signaling and Differential Actions in Target Tissues Compared to IGF-I
Kelly, P. A., Bachelot, A., Sotiropoulos, A., & Binart, N. (2005) · Springer eBooks · doi:10.1007/3-540-28902-x_6
MOLEKULARNE I CYTOGENETYCZNE W OCENIE CECH UYTKOWOŒCI ROZRODCZEJ LOCH RAS PBZ I WBP
Bogdziñska, M. (2010)
TRANSPLANTATION OF ADIPOSE TISSUE AS A REPLACEMENT THERAPY
Ablamunits, V. G., & Klebanov, S. (2015) · Russian Journal of Transplantology and Artificial Organs · doi:10.15825/1995-1191-2014-4-135-143
Pathogenesis and Aetiology of Female Genital Malformations
Liatsikos, S. A. (2014) · Springer eBooks · doi:10.1007/978-1-4471-5146-3_2
The effect of follicular aging on gene expression in oocytes and granulosal cells.
Lingenfelter, B. M. (2008) · The Research Repository @ WVU (West Virginia University) · doi:10.33915/etd.9309
Régulation des fonctions de l’épithélium épididymaire des mammifères: état des lieux
Britan, A., & Drevet, J. R. (2006) · Andrologie · doi:10.1007/bf03034859
Transgenic models of uterine biology
Bagchi, I. C., & Bagchi, M. K. (2008) · CRC Press eBooks · doi:10.3109/9780203091500-16
Lee, Y.-I., Shin, J.-O., Kim, M. Y., & Chun, S. (2006) · Korean Journal of Fertility and Sterility
Energy status and ovarian follicular development
Meng, L. (2016) · doi:10.18174/389440
dos Santos, R. D. (2015) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.42.2016.tde-18042016-101410
Omari, S. (2014) · TSpace (University of Toronto)
EXTRACELLULAR VESICLES IN OVARIAN ANTRAL FOLLICLES: CHARACTERIZATION AND FUNCTIONS
Hung, W. (2016) · KU ScholarWorks (University of Kansas)
Ovarian and Hypothalamic Aging
Kucherov, A., & Büyük, E. (2019) · Springer eBooks · doi:10.1007/978-3-030-23235-1_2
Al-Saaidi, J. A., Mohammed-Salih, & Al-Ali, A. H. (2014) · AL-QADISIYAH MEDICAL JOURNAL
Association of Interleukin-16 rs4778889 T>C Gene Polymorphism with Cancer Risk: a Meta-analysisPreprint
Lei, Q., Zhao, J., Yutong, Z., Ma, C., Chaobin, L., Jiwen, C., & Li, C. (2020) · doi:10.21203/rs.3.rs-19338/v1
Gonadotropin regulation of granulosa cells through follicular development and ovulation
Madogwe, E. (2020) · eScholarship@McGill (McGill) · doi:10.82308/15780
Physiologie und Pathologie des Geburtsbeginns
Schneider, H., Helmer, H., Husslein, P. W., Egarter, C., von Steinburg, S. P., & Lengyel, E. R. (2007) · Springer eBooks · doi:10.1007/978-3-540-33897-0_24
Yang, J., Zhang, X., Guo, J., Chen, Q., & Huang, G. (2022) · Research Square · doi:10.21203/rs.3.rs-1256203/v1
Physiologie und Pathologie des Geburtsbeginns
Schneider, H., Helmer, H., Husslein, P. W., Egarter, C., von Steinburg, S. P., & Lengyel, E. R. (2004) · Springer eBooks · doi:10.1007/978-3-642-18574-8_24
Kelder, B. (2010) · Springer eBooks · doi:10.1007/978-3-642-11183-9_58
van Lier, E., Meikle, A., Eriksson, H., & Sahlin, L. (2006) · Acta veterinaria Scandinavica · doi:10.1186/1751-0147-1-5
Gestational vinclozolin exposure suppresses fetal Leydig cell development in ratsPreprint
Wu, K., Li, Y., Pan, P., Li, Z., Yu, Y., Ma, F., Tian, L., Fang, Y., Wang, Y., & Ge, R. (2020) · doi:10.21203/rs.2.23589/v1
Transgenic models of uterine biology
Bagchi, I. C., & Bagchi, M. K. (2008) · Reproductive medicine and assisted reproductive techniques series · doi:10.3109/9780203091500.011
Proteomic applications for studies of bull fertility
Viana, A. G. D. A. (2022) · doi:10.47328/ufvbbt.2022.651
Yang, Y. (2020) · Chula Digiverse · doi:10.58837/chula.the.2020.476
Estudio fenotípico y genómico de la edad de madurez sexual de machos bovinos
de Iraola, J. J. (2023) · doi:10.35537/10915/151531
Mohamed, D. S., Mantawy, E. M., Said, R. S., Kassem, D. H., Gad, A. M., & El‐Demerdash, E. (2023) · Archives of Pharmaceutical Sciences Ain Shams University · doi:10.21608/aps.2023.251808.1147
Liu, H., Gong, Y., Qu, X., Cui, S., & Zhang, D. (2025) · PLoS ONE · doi:10.1371/journal.pone.0329503
Endo- und parakrine Regulation der Gonadenfunktion
Schöneberg, T. (2006) · Springer eBooks · doi:10.1007/3-540-28782-5_25
Insulin-Like Growth Factor Signaling during Myogenesis.
Ren, H. (2009) · Deep Blue (University of Michigan)
Etude du rôle d'EXOSC10 dans l'ovogenèse et la folliculogenèse
Demini, L. (2022) · theses.fr (ABES) · doi:10.70675/bfa3d8f8z3ef8z46f0zb974z56c9ada53cb4
Influence des concentrations hormonales folliculaires sur la qualité ovocytaire
Scheffler, F. (2021) · theses.fr (ABES) · doi:10.70675/e9a16666za64cz449ez9fe4z363e89b91f68
Analyse de la régulation de l'homéostasie des acides biliaires au sein des testicules
Holota, H. (2024) · theses.fr (ABES) · doi:10.70675/87a97831z9d93z48dazb8b7z8e7a929fc132
Волеводз, Н. Н., Vorontsova, M. V., Nevolnikov, D. Y., Grigoryan, O. R., Vorotnikova, S. Y., & Михеев, Р. К. (2026) · Problems of Endocrinology · doi:10.14341/probl13780
Rahman, K. M. (2014) · doi:10.7282/t3c53j57
GENE EXPRESSION PROFILING OF BOVINE OVARIAN FOLLICULAR SELECTION
Antoniou, E., Liu, Z., Youngquist, R. S., & Garverick, A. (2007) · Biology of Reproduction · doi:10.1093/biolreprod/77.s1.98
Metadata
- Authors
- Baker, J., Hardy, M. P., Zhou, J., Bondy, C., Lupu, F., Bellvé, A. R., & Efstratiadis, A.
- Affiliations
- Columbia University (US)
- Venue
- Molecular Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1996-07
- Volume
- 10
- Issue
- 7
- Pages
- 903-918
- ISSN
- 0888-8809 (ISSN-L)
- 1944-9917
- OpenAlex
- W2065752045
- Cited by
- 674
- References
- 45
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 11 · 2023: 18 · 2022: 19 · 2021: 24 · 2020: 29 · 2019: 20 · 2018: 29 · 2017: 19 · 2016: 20 · 2015: 20 · 2014: 23 · 2013: 23 · 2012: 16
- FWCI
- 19.42
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Molecular Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01hd029010-03, 5r01hd028342-04)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-29010, HD-28342, HD32588)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- insulin-like growth factor I, male infertility, dwarfism, spermatogenesis, Leydig cell development, androgen deficiency, androgenization, epididymis, female infertility, ovulation, myometrium, gonadotropin resistance, IGF-1 receptor, reproductive tract development
- MeSH terms
- Animals, Epididymis, Female, Infertility, Insulin-Like Growth Factor I, Male, Mice, Mutant Strains, Mutation, Organ Size, Ovary, Reproduction, Sperm Motility, Testis, Testosterone, Uterus, Gene Expression Regulation, Developmental, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
