Expression and Characterization of Recombinant Type 2 3α-Hydroxysteroid Dehydrogenase (HSD) from Human Prostate: Demonstration of Bifunctional 3α/17β-HSD Activity and Cellular Distribution

Lin, Hsueh-Kung, Jez, Joseph M., Schlegel, Brian P., Peehl, Donna M., Pachter, Jonathan A., Penning, Trevor M.·1997·Molecular Endocrinology
DOI 10.1210/mend.11.13.0026

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  11. Members of the nuclear factor 1 transcription factor family regulate rat 3alpha-hydroxysteroid/dihydrodiol dehydrogenase (3alpha-HSD/DD AKR1C9) gene expression: a member of the aldo-keto reductase superfamily.
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  12. Structure and activity of the murine type 5 17β-hydroxysteroid dehydrogenase gene
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  13. A 3-(4-nitronaphthen-1-yl) amino-benzoate analog as a bifunctional AKR1C3 inhibitor and AR antagonist: Head to head comparison with other advanced AKR1C3 targeted therapeutics
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  15. Role of human type 3 3α-hydroxysteroid dehydrogenase (AKR1C2) in androgen metabolism of prostate cancer cells
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  16. Biosynthesis of the Neurosteroid 3 -Hydroxy-4-pregnen-20-one (3 HP), a Specific Inhibitor of FSH Release
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  17. Molecular cloning, modeling, and localization of rat type 10 17β-hydroxysteroid dehydrogenase1Nucleotide sequences of cDNAs of rat and mouse type 10 17β-HSDs have been deposited in the GeneBank™/EBI Data Bank with accession number AF069770 and AF233685, respectively.1
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  18. Expression of 17β-Hydroxysteroid Dehydrogenase Type 5 in Human Ovary: A Pilot Study
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  19. Sulforaphane Preconditioning Sensitizes Human Colon Cancer Cells towards the Bioreductive Anticancer Prodrug PR-104A
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  23. Characterization of the basal promoter element of the human type 5 17beta-hydroxysteroid dehydrogenase gene
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  24. Development of Biaryl-Containing Aldo-Keto Reductase 1C3 (AKR1C3) Inhibitors for Reversing AKR1C3-Mediated Drug Resistance in Cancer Treatment
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  26. Triazole ring-opening leads to the discovery of potent nonsteroidal 17β-hydroxysteroid dehydrogenase type 2 inhibitors
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  27. 5α‐androstane‐3α,17β‐diol supports human prostate cancer cell survival and proliferation through androgen receptor‐independent signaling pathways: Implication of androgen‐independent prostate cancer progression
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  33. Novel N-methylsulfonamide and retro-N-methylsulfonamide derivatives as 17β-hydroxysteroid dehydrogenase type 2 (17β-HSD2) inhibitors with good ADME-related physicochemical parameters
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  35. 5α-Androstane-3α,17β-diol activates pathway that resembles the epidermal growth factor responsive pathways in stimulating human prostate cancer LNCaP cell proliferation
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  39. Expression of mRNAs for dihydrodiol dehydrogenase isoforms in human tissues.
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  42. Engineering steroid hormone specificity into aldo-keto reductases
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  43. Sequential transformation of 4-androstenedione into dihydrotestosterone in prostate carcinoma (DU-145) cells indicates that 4-androstenedione and not testosterone is the substrate of 5α-reductase
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  47. Developmental Evaluation of Aldo-keto Reductase 1C3 Expression in the Cryptorchid Testis
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  48. Increased Expression of Genes Converting Adrenal Androgens to Testosterone in Castration-Recurrent Prostate Cancer
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  54. Purification, crystallization and preliminary X-ray diffraction results of human 17β-hydroxysteroid dehydrogenase type 5
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  56. Testosterone sulfotransferase: Evidence in the guinea pig that this reaction is carried out by 3α-hydroxysteroid sulfotransferase
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