Penning, Trevor M.

Role of Quinones in Toxicology

Bolton, J. L., Trush, M. A., Penning, T. M., Dryhurst, G., & Monks, T. J. (2000) · Chemical Research in Toxicology

Bioactive Compounds and Antitumor AgentsCarcinogens and Genotoxicity Assessment

Cited by 1,703

Increased Expression of Genes Converting Adrenal Androgens to Testosterone in Androgen-Independent Prostate Cancer

Stanbrough, M., Bubley, G. J., Ross, K., Golub, T. R., Rubin, M. A., Penning, T. M., Febbo, P. G., & Balk, S. P. (2006) · Cancer Research

Prostate Cancer Treatment and ResearchHormonal and reproductive studies

Cited by 1,082

Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

Tebay, L. E., Robertson, H., Durant, S. T., Vitale, S. R., Penning, T. M., Dinkova-Kostova, A. T., & Hayes, J. D. (2015) · Free Radical Biology and Medicine

Genomics, phytochemicals, and oxidative stressRedox biology and oxidative stress

Cited by 837

Human 3α-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones

PENNING, T. M., BURCZYNSKI, M. E., JEZ, J. M., HUNG, C.-F., LIN, H.-K., MA, H., MOORE, M., PALACKAL, N., & RATNAM, K. (2000) · Biochemical Journal

Aldose Reductase and TaurineSteroid Chemistry and Biochemistry

Cited by 649

The biochemical basis for increased testosterone production in theca cells propagated from patients with polycystic ovary syndrome

Nelson, V. L., Qin, K.-N., Rosenfield, R. L., Wood, J. R., Penning, T. M., Legro, R. S., Strauss, J. F., & McAllister, J. M. (2001) · The Journal of Clinical Endocrinology & Metabolism

Ovarian function and disordersReproductive Biology and Fertility

Cited by 405

Human Cytosolic 3α-Hydroxysteroid Dehydrogenases of the Aldo-keto Reductase Superfamily Display Significant 3β-Hydroxysteroid Dehydrogenase Activity

Steckelbroeck, S., Jin, Y., Gopishetty, S., Oyesanmi, B., & Penning, T. M. (2004) · Journal of Biological Chemistry

Aldose Reductase and TaurineSteroid Chemistry and Biochemistry

Cited by 270

Role of aldo-keto reductase family 1 (AKR1) enzymes in human steroid metabolism

Rižner, T. L., & Penning, T. M. (2014) · Steroids

Aldose Reductase and TaurineSteroid Chemistry and Biochemistry

Cited by 217

Expression and Characterization of Recombinant Type 2 3α-Hydroxysteroid Dehydrogenase (HSD) from Human Prostate: Demonstration of Bifunctional 3α/17β-HSD Activity and Cellular Distribution

Lin, H.-K., Jez, J. M., Schlegel, B. P., Peehl, D. M., Pachter, J. A., & Penning, T. M. (1997) · Molecular Endocrinology

Prostate Cancer Treatment and ResearchAldose Reductase and Taurine

Cited by 194

Steroid hormone transforming aldo–keto reductases and cancer

Penning, T. M., & Byrns, M. C. (2009) · Annals of the New York Academy of Sciences

Aldose Reductase and TaurineProstate Cancer Treatment and Research

Cited by 181

Structural and functional biology of aldo-keto reductase steroid transforming enzymes

Penning, T. M., Wangtrakuldee, P., & Auchus, R. J. (2019) · Endocrine Reviews

Aldose Reductase and TaurineSteroid Chemistry and Biochemistry

Cited by 164

AKR1C1 and AKR1C3 may determine progesterone and estrogen ratios in endometrial cancer

Rižner, T. L., Šmuc, T., Rupreht, R., Šinkovec, J., & Penning, T. M. (2006) · Molecular and Cellular Endocrinology

Estrogen and related hormone effectsEndometrial and Cervical Cancer Treatments

Cited by 159

An indomethacin analogue, N-(4-chlorobenzoyl)-melatonin, is a selective inhibitor of aldo-keto reductase 1C3 (type 2 3α-HSD, type 5 17β-HSD, and prostaglandin F synthase), a potential target for the treatment of hormone dependent and hormone independent malignancies

Byrns, M. C., Steckelbroeck, S., & Penning, T. M. (2008) · Biochemical Pharmacology

Aldose Reductase and TaurineBioactive Compounds and Antitumor Agents

Cited by 145

AKR1C3 as a target in castrate resistant prostate cancer

Adeniji, A. O., Chen, M., & Penning, T. M. (2013) · The Journal of Steroid Biochemistry and Molecular Biology

Prostate Cancer Treatment and ResearchAldose Reductase and Taurine

Cited by 143

Three-dimensional structure of rat liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase: a member of the aldo-keto reductase superfamily.

Hoog, S. S., Pawlowski, J. E., Alzari, P. M., Penning, T. M., & Lewis, M. (1994) · Proceedings of the National Academy of Sciences

Aldose Reductase and TaurineEnzyme Structure and Function

Cited by 137

Human type 3 3α-hydroxysteroid dehydrogenase (aldo-keto reductase 1C2) and androgen metabolism in prostate cells

Rižner, T. L., Lin, H. K., Peehl, D. M., Steckelbroeck, S., Bauman, D. R., & Penning, T. M. (2003) · Endocrinology

Aldose Reductase and TaurineProstate Cancer Treatment and Research

Cited by 132

Increased expression of type 2 3α-hydroxysteroid dehydrogenase/type 5 17β-hydroxysteroid dehydrogenase (AKR1C3) and its relationship with androgen receptor in prostate carcinoma

Fung, K.-M., Samara, E. N. S., Wong, C., Metwalli, A., Krlin, R., Bane, B., Liu, C. Z., Yang, J. T., Pitha, J. V., Culkin, D. J., et al. (2006) · Endocrine Related Cancer

Prostate Cancer Treatment and ResearchAldose Reductase and Taurine

Cited by 129

Identification of the Major Oxidative 3α-Hydroxysteroid Dehydrogenase in Human Prostate That Converts 5α-Androstane-3α,17β-diol to 5α-Dihydrotestosterone: A Potential Therapeutic Target for Androgen-Dependent Disease

Bauman, D. R., Steckelbroeck, S., Williams, M. V., Peehl, D. M., & Penning, T. M. (2006) · Molecular Endocrinology

Prostate Cancer Treatment and ResearchSteroid Chemistry and Biochemistry

Cited by 120

AKR1C3 (type 5 17β-hydroxysteroid dehydrogenase/prostaglandin F synthase): Roles in malignancy and endocrine disorders

Penning, T. M. (2019) · Molecular and Cellular Endocrinology

Aldose Reductase and TaurineProstate Cancer Treatment and Research

Cited by 117

Aldo–keto reductase 1C3 expression in MCF-7 cells reveals roles in steroid hormone and prostaglandin metabolism that may explain its over-expression in breast cancer

Byrns, M. C., Duan, L., Lee, S. H., Blair, I. A., & Penning, T. M. (2010) · The Journal of Steroid Biochemistry and Molecular Biology

Aldose Reductase and TaurineEstrogen and related hormone effects

Cited by 116

Structure of 3α-Hydroxysteroid/Dihydrodiol Dehydrogenase Complexed with NADP+

Bennett, M. J., Schlegel, B. P., Jez, J. M., Penning, T. M., & Lewis, M. (1996) · Biochemistry

Enzyme Structure and FunctionAldose Reductase and Taurine

Cited by 92

Crystal Structure of Human Liver Δ4-3-Ketosteroid 5β-Reductase (AKR1D1) and Implications for Substrate Binding and Catalysis

Di Costanzo, L., Drury, J. E., Penning, T. M., & Christianson, D. W. (2008) · Journal of Biological Chemistry

Enzyme Structure and FunctionSteroid Chemistry and Biochemistry

Cited by 79

The arginine 276 anchor for NADP(H) dictates fluorescence kinetic transients in 3α-hydroxysteroid dehydrogenase, a representative aldo-keto reductase

Ratnam, K., Ma, H., & Penning, T. M. (1999) · Biochemistry

Aldose Reductase and TaurineEnzyme Structure and Function

Cited by 68

Tibolone is metabolized by the 3α/3β-hydroxysteroid dehydrogenase activities of the four human isozymes of the aldo–keto reductase 1C subfamily: inversion of stereospecificity with a Δ5(10)-3-ketosteroid

Steckelbroeck, S., Jin, Y., Oyesanmi, B., Kloosterboer, H. J., & Penning, T. M. (2004) · Molecular Pharmacology

Aldose Reductase and TaurineSteroid Chemistry and Biochemistry

Cited by 64

Overexpression of aldo–keto reductase 1C3 (AKR1C3) in LNCaP cells diverts androgen metabolism towards testosterone resulting in resistance to the 5α-reductase inhibitor finasteride

Byrns, M. C., Mindnich, R., Duan, L., & Penning, T. M. (2012) · The Journal of Steroid Biochemistry and Molecular Biology

Prostate Cancer Treatment and ResearchAldose Reductase and Taurine

Cited by 60