The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Fatigue in MS is related to sympathetic vasomotor dysfunction
Abstract
The authors studied standard autonomic function tests and measures of heart rate variability in 60 patients with multiple sclerosis (MS) and correlated results with the Fatigue Severity Scale and the Modified Fatigue Impact Scale. The authors found that autonomic responses correlated with fatigue resembling a hypoadrenergic orthostatic response, possibly due to a sympathetic vasomotor lesion with intact vagal heart control. Treatments to control sympathetic dysfunction for MS-associated fatigue deserve further study.
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“Specifically, in MS patients, various measures of autonomic dysfunction correlate strongly with individual fatigue levels (Flachenecker et al., 2003; Cortez et al., 2015).”
From Allostatic Self-efficacy: A Metacognitive Theory of Dyshomeostasis-Induced Fatigue and Depression (2016) · cites this paper as Flachenecker et al., 2003
Citations
Cites
Assessment of autonomic function in humans by heart rate spectral analysis
Pomeranz, B., Macaulay, R. J., Caudill, M. A., Kutz, I., Adam, D., Gordon, D., Kilborn, K. M., Barger, A. C., Shannon, D. C., Cohen, R. J., et al. (1985) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1985.248.1.h151 · Cited by 2,876
Flachenecker, P., Kümpfel, T., Kallmann, B. A., Gottschalk, M., Grauer, O. M., Rieckmann, P., Trenkwalder, C., & Toyka, K. V. (2002) · Multiple Sclerosis Journal · doi:10.1191/1352458502ms839oa · Cited by 635
Self-citationFatigue in multiple sclerosis: current understanding and future directions.
Schwid, S. R., Covington, M., Segal, B. M., & Goodman, A. D. (2002) · PubMed · Cited by 225
Mathias, C. J., Mallipeddi, R., & Bleasdale-Barr, K. (1999) · Journal of Neurology · doi:10.1007/s004150050479 · Cited by 178
Cardiovascular autonomic dysfunction in multiple sclerosis: correlation with orthostatic intolerance
Flachenecker, P., Wolf, A., Krauser, M., Hartung, H., & Reiners, K. (1999) · Journal of Neurology · doi:10.1007/s004150050407 · Cited by 112
Self-citationCardiovascular autonomic dysregulation and fatigue in multiple sclerosis
Merkelbach, S., Dillmann, U., Kölmel, C., Holz, J., & Müller, M. (2001) · Multiple Sclerosis Journal · doi:10.1177/135245850100700508 · Cited by 63
Is fatigue in patients with multiple sclerosis related to autonomic dysfunction?
Keselbrener, L., AKSELROD, S., Ahiron, A., Eldar, M., Barak, Y., & Rotstein, Z. (2000) · Clinical Autonomic Research · doi:10.1007/bf02291352 · Cited by 58
Egg, R., Högl, B., Glatzl, S., Beer, R., & Berger, T. (2002) · Multiple Sclerosis Journal · doi:10.1191/1352458502ms793oa · Cited by 27
Research works printed but not linked: 2
- Therapeutics and Technology Assessment Subcommittee. Clinical autonomic testing. Neurology . 1996; 46: 873–880.
- Wieling W Karemaker JM. Measurement of heart rate and blood pressure to evaluate disturbances in neurocardiovascular control. In: Mathias CJ Bannister R eds. Autonomic failure. A textbook of clinical disorders of the autonomic nervous system. 4th ed. New York: Oxford University Press 1999: 196–210.
Cited by
Sorted by citations
Allostatic Self-efficacy: A Metacognitive Theory of Dyshomeostasis-Induced Fatigue and Depression
Stephan, K. E., Manjaly, Z. M., Mathys, C. D., Weber, L. A. E., Paliwal, S., Gard, T., Tittgemeyer, M., Fleming, S. M., Haker, H., Seth, A. K., et al. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00550 · Cited by 437
“Specifically, in MS patients, various measures of autonomic dysfunction correlate strongly with individual fatigue levels (Flachenecker et al., 2003; Cortez et al., 2015).”
BackgroundPathophysiological and cognitive mechanisms of fatigue in multiple sclerosis
Manjaly, Z., Harrison, N. A., Critchley, H., Tri, C., Stefanics, G., Wenderoth, N., Lutterotti, A., Müller, A. E., & Stephan, K. E. (2019) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2018-320050 · Cited by 358
Mental fatigue caused by prolonged cognitive load associated with sympathetic hyperactivity
Mizuno, K., Tanaka, M., Yamaguti, K., Kajimoto, O., Kuratsune, H., & Watanabe, Y. (2011) · Behavioral and Brain Functions · doi:10.1186/1744-9081-7-17 · Cited by 298
Multiple sclerosis-associated fatigue
Krupp, L., Serafin, D., & Christodoulou, C. (2010) · Expert Review of Neurotherapeutics · doi:10.1586/ern.10.99 · Cited by 241
Symptoms of autonomic dysfunction in chronic fatigue syndrome
Newton, J. L., Okonkwo, O., Sutcliffe, K., Seth, A., Shin, J. Y., & Jones, D. E. (2007) · QJM · doi:10.1093/qjmed/hcm057 · Cited by 180
Metadata
- Authors
- Flachenecker, P., Rufer, A., Bihler, I., Hippel, C., Reiners, K., Toyka, K. V., & Kesselring, J.
- Affiliations
- University of Würzburg (DE)
- Venue
- Neurology
- Published
- 2003-09-23
- Volume
- 61
- Issue
- 6
- Pages
- 851-853
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W1970120310
- Cited by
- 125
- References
- 8
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 11 · 2022: 5 · 2021: 4 · 2020: 3 · 2019: 6 · 2018: 2 · 2017: 8 · 2016: 5 · 2015: 10 · 2014: 4 · 2013: 6 · 2012: 8
- FWCI
- 2.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Syncope and Autonomic Disorders
- Keywords
- multiple sclerosis, fatigue, autonomic dysfunction, sympathetic nervous system, vasomotor dysfunction, heart rate variability, orthostatic response, Fatigue Severity Scale, Modified Fatigue Impact Scale
- MeSH terms
- Adult, Aged, Blood Pressure, Electrocardiography, Fatigue, Female, Fourier Analysis, Heart Rate, Humans, Hypotension, Orthostatic, Male, Middle Aged, Multiple Sclerosis, Posture, Surveys and Questionnaires, Severity of Illness Index, Sympathetic Nervous System, Vagus Nerve, Valsalva Maneuver, Vasomotor System, Hand Strength
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