Cited by 125Multiple Sclerosis Research StudiesHeart Rate Variability and Autonomic ControlCardiovascular Syncope and Autonomic Disorders

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Fatigue in MS is related to sympathetic vasomotor dysfunction

Flachenecker, P., Rufer, A., Bihler, I., Hippel, C., Reiners, K., Toyka, K.V., Kesselring, J.·2003·Neurology

DOI 10.1212/01.wnl.0000080365.95436.b8

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Abstract

The authors studied standard autonomic function tests and measures of heart rate variability in 60 patients with multiple sclerosis (MS) and correlated results with the Fatigue Severity Scale and the Modified Fatigue Impact Scale. The authors found that autonomic responses correlated with fatigue resembling a hypoadrenergic orthostatic response, possibly due to a sympathetic vasomotor lesion with intact vagal heart control. Treatments to control sympathetic dysfunction for MS-associated fatigue deserve further study.

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Assessment of autonomic function in humans by heart rate spectral analysis
Pomeranz, B., Macaulay, R. J., Caudill, M. A., Kutz, I., Adam, D., Gordon, D., Kilborn, K. M., Barger, A. C., Shannon, D. C., Cohen, R. J., et al. (1985) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1985.248.1.h151 · Cited by 2,876
Fatigue in multiple sclerosis: a comparison of different rating scales and correlation to clinical parameters
Flachenecker, P., Kümpfel, T., Kallmann, B. A., Gottschalk, M., Grauer, O. M., Rieckmann, P., Trenkwalder, C., & Toyka, K. V. (2002) · Multiple Sclerosis Journal · doi:10.1191/1352458502ms839oa · Cited by 635
Self-citation
Fatigue in multiple sclerosis: current understanding and future directions.
Schwid, S. R., Covington, M., Segal, B. M., & Goodman, A. D. (2002) · PubMed · Cited by 225
Symptoms associated with orthostatic hypotension in pure autonomic failure and multiple system atrophy
Mathias, C. J., Mallipeddi, R., & Bleasdale-Barr, K. (1999) · Journal of Neurology · doi:10.1007/s004150050479 · Cited by 178
Cardiovascular autonomic dysfunction in multiple sclerosis: correlation with orthostatic intolerance
Flachenecker, P., Wolf, A., Krauser, M., Hartung, H., & Reiners, K. (1999) · Journal of Neurology · doi:10.1007/s004150050407 · Cited by 112
Self-citation
Cardiovascular autonomic dysregulation and fatigue in multiple sclerosis
Merkelbach, S., Dillmann, U., Kölmel, C., Holz, J., & Müller, M. (2001) · Multiple Sclerosis Journal · doi:10.1177/135245850100700508 · Cited by 63
Is fatigue in patients with multiple sclerosis related to autonomic dysfunction?
Keselbrener, L., AKSELROD, S., Ahiron, A., Eldar, M., Barak, Y., & Rotstein, Z. (2000) · Clinical Autonomic Research · doi:10.1007/bf02291352 · Cited by 58
Autonomic instability, as measured by pupillary unrest, is not associated with multiple sclerosis fatigue severity
Egg, R., Högl, B., Glatzl, S., Beer, R., & Berger, T. (2002) · Multiple Sclerosis Journal · doi:10.1191/1352458502ms793oa · Cited by 27

Show all 8 references

Research works printed but not linked: 2

Therapeutics and Technology Assessment Subcommittee. Clinical autonomic testing. Neurology . 1996; 46: 873–880.
Wieling W Karemaker JM. Measurement of heart rate and blood pressure to evaluate disturbances in neurocardiovascular control. In: Mathias CJ Bannister R eds. Autonomic failure. A textbook of clinical disorders of the autonomic nervous system. 4th ed. New York: Oxford University Press 1999: 196–210.

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Self-citation

Authors: Flachenecker, P., Rufer, A., Bihler, I., Hippel, C., Reiners, K., Toyka, K. V., & Kesselring, J.
Affiliations: University of Würzburg (DE)
ORCID: Reiners, K.
Kesselring, J.
Venue: Neurology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2003-09-23
Volume: 61
Issue: 6
Pages: 851-853
ISSN: 0028-3878 (ISSN-L)
1526-632X
DOI: 10.1212/01.wnl.0000080365.95436.b8
OpenAlex: W1970120310
Cited by: 125
References: 8
Citations by year: 2025: 1 · 2024: 3 · 2023: 11 · 2022: 5 · 2021: 4 · 2020: 3 · 2019: 6 · 2018: 2 · 2017: 8 · 2016: 5 · 2015: 10 · 2014: 4 · 2013: 6 · 2012: 8
FWCI: 2.40
Type: journal article
Language: en
Open access: closed
Locations: Neurology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Syncope and Autonomic Disorders
Keywords: multiple sclerosis, fatigue, autonomic dysfunction, sympathetic nervous system, vasomotor dysfunction, heart rate variability, orthostatic response, Fatigue Severity Scale, Modified Fatigue Impact Scale
MeSH terms: Adult, Aged, Blood Pressure, Electrocardiography, Fatigue, Female, Fourier Analysis, Heart Rate, Humans, Hypotension, Orthostatic, Male, Middle Aged, Multiple Sclerosis, Posture, Surveys and Questionnaires, Severity of Illness Index, Sympathetic Nervous System, Vagus Nerve, Valsalva Maneuver, Vasomotor System, Hand Strength

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Fatigue in MS is related to sympathetic vasomotor dysfunction

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