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Case-control study of SUDEP
Abstract
OBJECTIVE: To examine the influence of various factors on the risk of sudden unexpected death in epilepsy (SUDEP). METHODS: The authors investigated 154 cases in which a postmortem examination was performed. Each case had four controls with epilepsy from the community, matched for age and geographic location. Backward stepwise conditional logistic regression analysis was performed and odds ratios for risk and protection were determined. RESULTS: The risk of SUDEP was increased with a history of generalized tonic-clonic seizures in the previous 3 months (odds ratio [OR]: 13.8, 95% CI: 6.6 to 29.1). The presence of supervision at night was found to be protective (OR: 0.4, 95% CI: 0.2 to 0.8) when a supervising individual shared the same bedroom or when special precautions such as a listening device were employed (OR: 0.1, 95% CI: 0.0 to 0.3). CONCLUSION: This work lends support to the view that SUDEP is a seizure-related phenomenon and that control of tonic-clonic seizures is important in its prevention. Nocturnal supervision seems to protect against SUDEP.
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Cited by
Epilepsy across the spectrum: Promoting health and understanding.
England, M. J., Liverman, C. T., Schultz, A. M., & Strawbridge, L. M. (2012) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2012.06.016 · Cited by 732
Sudden unexpected death in epilepsy: epidemiology, mechanisms, and prevention
Devinsky, O., Hesdorffer, D. C., Thurman, D. J., Lhatoo, S., & Richerson, G. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)30158-2 · Cited by 721
Sudden unexpected death in epilepsy: risk factors and potential pathomechanisms
Surges, R., Thijs, R. D., Tan, H. L., & Sander, J. W. (2009) · Nature Reviews Neurology · doi:10.1038/nrneurol.2009.118 · Cited by 431
Self-citationSudden unexpected death in epilepsy: people with nocturnal seizures may be at highest risk
Lamberts, R. J., Thijs, R. D., Laffan, A., Langan, Y., & Sander, J. W. (2012) · Epilepsia · doi:10.1111/j.1528-1167.2011.03360.x · Cited by 322
Self-citationAutomated seizure detection systems and their effectiveness for each type of seizure
Ulate-Campos, A., Coughlin, F., Gaínza-Lein, M., Fernández, I. S., Pearl, P. L., & Loddenkemper, T. (2016) · Seizure · doi:10.1016/j.seizure.2016.06.008 · Cited by 233
Metadata
- Authors
- Langan, Y., Nashef, L., & Sander, J. W.
- Venue
- Neurology
- Published
- 2005-04-12
- Volume
- 64
- Issue
- 7
- Pages
- 1131-1133
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2012276882
- Cited by
- 433
- References
- 0
- FWCI
- 7.33
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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