The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
Anti-α4 integrin therapy for multiple sclerosis: Mechanisms and rationale
Abstract
The symptoms, severity, and course of multiple sclerosis (MS) vary among patients, leading to complex treatment issues. In recent years, research has focused on specific adhesion molecules that participate in the activation and function of lymphocytes, especially the migration of these cells to sites of inflammation. In particular, the integrin, very late activation antigen (VLA)-4, has been implicated in mediating adhesion and migration of immune cells through interaction with its ligand, vascular cell adhesion molecule (VCAM)-1. VLA-4 is comprised of alpha4/beta1 and is critical in mediating Th-1 cell migration in the animal model of MS, experimental autoimmune encephalomyelitis, and has been the target of several recent clinical trials in MS. The humanized monoclonal antibody to alpha4 integrin, natalizumab (Tysabri, Biogen Idec/Elan), was recently approved in the United States for the treatment of relapsing MS. The authors discuss the mechanisms by which alpha4 integrins alter lymphocyte function as a rationale for anti-alpha4 integrin use in MS.
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Cites
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Cited by
Wu, W.-F., Tan, X.-J., Dai, Y.-B., Krishnan, V., Warner, M., & Gustafsson, J.-Å. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1300313110 · Cited by 149
Monocytes regulate T cell migration through the glia limitans during acute viral encephalitis
Savarin, C., Stohlman, S. A., Atkinson, R., Ransohoff, R. M., & Bergmann, C. C. (2010) · Journal of Virology · doi:10.1128/jvi.00051-10 · Cited by 68
Metadata
- Authors
- Rice, G. P. A., Hartung, H.-P., & Calabresi, P. A.
- Venue
- Neurology
- Published
- 2005-04-26
- Volume
- 64
- Issue
- 8
- Pages
- 1336-1342
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2059114092
- Cited by
- 305
- References
- 66
- FWCI
- 14.19
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rice, G. P. A., Hartung, H.-P., & Calabresi, P. A. (2005). Anti-α4 integrin therapy for multiple sclerosis: Mechanisms and rationale. Neurology. https://doi.org/10.1212/01.wnl.0000158329.30470.d0
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
