APOE ε2/ε4 polymorphism and cerebral microbleeds on gradient-echo MRI
Abstract
The association of APOE genotypes with cerebral microbleeds (CMBs) was examined on the basis of the location of CMBs in 414 patients who were admitted primarily because of stroke. With respect to possession of the epsilon2 or epsilon4 allele, the adjusted odds ratio was 1.94 (1.05 to 3.58) for lobar CMBs but 1.21 (0.69 to 2.11) for nonlobar CMBs. This suggests that the pathogenesis of CMBs may differ depending on their location.
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Evidence independently supports link of both the APOE ε4 and ε2 allele with increased risk for microhemorrhages in humans.
“Evidence independently supports link of both the APOE ε4 and ε2 allele with increased risk for microhemorrhages in humans [51, 52, 54–57].”
From APOE Genotype Differentially Modulates Effects of Anti-Aβ, Passive Immunization in APP Transgenic Mice (2017) · cites this paper as [54]
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- Authors
- Kim, M., Bae, H. J., Lee, J., Kang, L., Lee, S., Kim, S., Lee, J. E., Lee, K. M., Yoon, B. W., Kwon, O., Koo, J. S., & Kim, B. K.
- Affiliations
- Korea University (KR)
- Venue
- Neurology
- Published
- 2005-11-08
- Volume
- 65
- Issue
- 9
- Pages
- 1474-1475
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2143060109
- Cited by
- 39
- References
- 9
- Citations by year
- 2026: 2 · 2024: 1 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 2 · 2012: 2
- FWCI
- 1.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Intracerebral and Subarachnoid Hemorrhage Research
- Health Sciences › Medicine › Neurology › Cerebrovascular and genetic disorders
- Health Sciences › Medicine › Neurology › Intracranial Aneurysms: Treatment and Complications
- Keywords
- cerebral microbleeds, gradient echo MRI, lobar microbleeds, stroke, APOE genotype
- MeSH terms
- Age Factors, Aged, Alcohol Drinking, Apolipoproteins E, Brain, Cerebral Arteries, Cerebral Hemorrhage, DNA Mutational Analysis, Female, Genetic Testing, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Polymorphism, Genetic, Predictive Value of Tests, Prospective Studies, Sex Factors, Smoking, Causality, Cerebral Amyloid Angiopathy, Genetic Predisposition to Disease, Apolipoprotein E4, Apolipoprotein E2
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