Dopamine transporter imaging study in parkinsonism occurring in fragile X premutation carriers
Abstract
The authors studied four patients with parkinsonism carrying the fragile X premutation using SPECT with ([23)I]FP-CIT. They found evidence of preserved presynaptic nigrostriatal function, suggesting that parkinsonism in the X fragile premutation might be related to postsynaptic dopaminergic changes or different neurotransmitter alterations.
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The only published molecular-imaging study of striatal DAT binding is a small investigation of four patients with parkinsonism carrying the FXS permutation, which found initial evidence of decreased striatal binding.
“The only published molecular-imaging study of striatal DAT binding is a small investigation of four patients with parkinsonism carrying the FXS permutation, which found initial evidence of decreased striatal binding [724].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [724]
Cites
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Dichter, G. S., Damiano, C. A., & Allen, J. A. (2012) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-4-19 · Cited by 299 · see citing works
- Authors
- Ceravolo, R., Antonini, A., Volterrani, D., Rossi, C., Goldwurm, S., Di Maria, E., Kiferle, L., Bonuccelli, U., & Murri, L.
- Affiliations
- University of Pisa (IT)
- From the Department of Neurosciences, Section of Neurology (Drs. Ceravolo, Rossi, Kiferle, Bonuccelli, and Murri), University of Pisa, Italy; Parkinson Institute (Drs. Antonini and Goldwurm), Istituti Clinici di Perfezionamento, Milan, Italy; Center of Nuclear Medicine (Dr. Volterrani), University of Pisa, Italy; Department of Neurosciences, Ophthalmology & Genetics, Section of Medical Genetics (Dr. Di Maria), University of Genova, Italy.
- Venue
- Neurology
- Published
- 2005-12-27
- Volume
- 65
- Issue
- 12
- Pages
- 1971-1973
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W1984551922
- Cited by
- 33
- References
- 12
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2019: 2 · 2018: 1 · 2016: 2 · 2015: 1 · 2014: 1 · 2013: 3 · 2012: 2
- FWCI
- 1.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- fragile X premutation, parkinsonism, dopamine transporter imaging, SPECT, neurotransmitter alterations
- MeSH terms
- Aged, Atrophy, Brain, Brain Mapping, Corpus Striatum, Dopamine, Female, Fragile X Syndrome, Heterozygote, Humans, Male, Middle Aged, Mutation, Neural Pathways, Synaptic Transmission, Parkinson Disease, Substantia Nigra, Syndrome, Tropanes, Biomarkers, Tomography, Emission-Computed, Single-Photon, Genetic Predisposition to Disease, Dopamine Plasma Membrane Transport Proteins
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