Cited by 299Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsAmyotrophic Lateral Sclerosis Research

The DOI matches its Crossref record; 83 of the 84 references it cites were found in a registry or an index.

A systematic review of neurotransmitter deficits and treatments in frontotemporal dementia

Open access

Huey, Edward D., Putnam, Karen T., Grafman, Jordan·2006·Neurology

DOI 10.1212/01.wnl.0000191304.55196.4dPMC PMC4499854

Open this paper in CoChat — free account

Abstract

OBJECTIVE: To evaluate neurotransmitter deficiencies and neurotransmitter-based treatments for frontotemporal dementia (FTD). METHODS: The authors conducted a systematic review of the literature on the mechanism and treatment of FTD and a meta-analysis of treatment studies of antidepressants for the behavioral symptoms of FTD. RESULTS: Patients with FTD show deficiencies in the serotonin and dopamine neurotransmitter systems, while the acetylcholine system appears relatively intact. Antidepressant treatment significantly improves behavioral symptoms in FTD, but most studies are small and uncontrolled. Serotonergic treatments appear to improve the behavioral but not cognitive symptoms of FTD. CONCLUSIONS: Studies of neurotransmitter deficiencies in frontotemporal dementia (FTD) can be helpful in developing treatments. Treatment studies on FTD are scarce, given the prevalence and severity of this illness. Larger, well-controlled treatment studies are required to reach more definitive conclusions about treatment efficacy. Multicenter studies are likely the best way to complete treatment studies in a timely manner.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1212/01.wnl.0000191304.55196.4d

Cites

83 of 83 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

[Japanese version of the Neuropsychiatric Inventory--a scoring system for neuropsychiatric disturbance in dementia patients].
Hirono, N., Mori, E., Ikejiri, Y., Imamura, T., Shimomura, T., Hashimoto, M., Yamashita, H., & Ikeda, M. (1997) · PubMed · Cited by 21,012
Special Care Units and Traditional Care in Dementia: Relationship with Behavior, Cognition, Functional Status and Quality of Life - A Review
Kok, J. S., Berg, I. J., & Scherder, E. J. A. (2013) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000353441 · Cited by 20,589
The Neuropsychiatric Inventory: Comprehensive assessment of psychopathology in dementia
Cummings, J. L., Mega, M., Gray, K., Rosenberg-Thompson, S., Carusi, D. A., & Gornbein, J. (1994) · Neurology · doi:10.1212/wnl.44.12.2308 · Cited by 7,568
Frontotemporal lobar degeneration: A consensus on clinical diagnostic criteria
Neary, D., Snowden, J. S., Gustafson, L., Passant, U., Stuss, D., Black, S., Freedman, M., Kertesz, A., Robert, P. H., Albert, M., et al. (1998) · Neurology · doi:10.1212/wnl.51.6.1546 · Cited by 5,047
Primary Progressive Aphasia
Weıntraub, S. (1990) · Archives of Neurology · doi:10.1001/archneur.1990.00530120075013 · Cited by 3,018
Clinical and neuropathological criteria for frontotemporal dementia. The Lund and Manchester Groups.
(1994) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.57.4.416 · Cited by 1,331
The prevalence of frontotemporal dementia
Ratnavalli, E., Brayne, C., Dawson, K. E., & Hodges, J. R. (2002) · Neurology · doi:10.1212/wnl.58.11.1615 · Cited by 1,182
Cerebral Glucose Metabolism in Adults with Hyperactivity of Childhood Onset
Zametkin, A. J., NORDAHL, T. E., Gross, M., King, A. C., Semple, W. E., Rumsey, J. M., Hamburger, S., & Cohen, R. M. (1990) · New England Journal of Medicine · doi:10.1056/nejm199011153232001 · Cited by 975
Pharmacological Treatment of Neuropsychiatric Symptoms of Dementia: A Review of the Evidence
Sink, K. M., Holden, K. F., & Yaffe, K. (2005) · JAMA · doi:10.1001/jama.293.5.596 · Cited by 910
Decreased β-Amyloid1-42and Increased Tau Levels in Cerebrospinal Fluid of Patients With Alzheimer Disease
Sunderland, T., Linker, G., Mirza, N., Putnam, K. T., Friedman, D. L., Kimmel, L. H., Bergeson, J., Manetti, G. J., Zimmermann, M., Tang, B., et al. (2003) · JAMA · doi:10.1001/jama.289.16.2094 · Cited by 656
Self-citation
Is there a role for 5-HT1A agonists in the treatment of depression?
Blier, P., & Ward, N. M. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01643-8 · Cited by 529
NEOCORTICAL CHOLINERGIC NEURONS IN ELDERLY PEOPLE
White, P., Goodhardt, M., Keet, J. P., Hiley, C. R., Carrasco, L. H., Williams, I. E. I., & Bowen, D. M. (1977) · The Lancet · doi:10.1016/s0140-6736(77)92114-6 · Cited by 489
Widespread origin of the primate mesofrontal dopamine system
Williams, S. (1998) · Cerebral Cortex · doi:10.1093/cercor/8.4.321 · Cited by 479
Frontotemporal Dementia: A Randomised, Controlled Trial with Trazodone
Lebert, F., Stekke, W., Hasenbroekx, C., & Pasquier, F. (2004) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000077171 · Cited by 387
Pick’s Disease
Constantinidis, J., Richard, J., & Tissot, R. (2008) · European Neurology · doi:10.1159/000114320 · Cited by 352
Attention Deficit–Hyperactivity Disorder
Rappley, M. D. (2005) · New England Journal of Medicine · doi:10.1056/nejmcp032387 · Cited by 296
Neurotransmitters and Suicidal Behavior
Åsberg, M. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb52359.x · Cited by 290
Differential effect of a dopaminergic agonist on prefrontal function in traumatic brain injury patients
McDowell, S. (1998) · Brain · doi:10.1093/brain/121.6.1155 · Cited by 269
The American Psychiatric Publishing textbook of psychopharmacology
(2010) · Choice Reviews Online · doi:10.5860/choice.47-4164 · Cited by 233
Apathy: a treatable syndrome
Marin, R. S., Fogel, B. S., Hawkins, J. W., Duffy, J., & Krupp, B. H. (1995) · Journal of Neuropsychiatry · doi:10.1176/jnp.7.1.23 · Cited by 229
Paroxetine does not improve symptoms and impairs cognition in frontotemporal dementia: a double-blind randomized controlled trial
Rahman, S., Nestor, P. J., Hodges, J. R., Sahakian, B. J., & Deakin, J. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1686-5 · Cited by 221
Clinical and Physiological Consequences of Rapid Tryptophan Depletion
Moore, P. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00161-5 · Cited by 210
Choline acetyltransferase activity and histopathology of frontal neocortex from biopsies of demented patients
Bowen, D. M., Benton, J. S., Spillane, J. A., Smith, C., & Allen, S. J. (1982) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(82)90026-0 · Cited by 195
Frontotemporal Dementia: Paroxetine as a Possible Treatment of Behavior Symptoms
Moretti, R., Torre, P., Antonello, R. M., Cazzato, G., & Bava, A. (2002) · European Neurology · doi:10.1159/000067021 · Cited by 173
Glucose metabolism and serotonin receptors in the frontotemporal lobe degeneration
Franceschi, M., Anchisi, D., Pelati, O., Zuffi, M., Matarrese, M., Moresco, R. M., Fazio, F., & Perani, D. (2005) · Annals of Neurology · doi:10.1002/ana.20365 · Cited by 170
Equivalent Occupancy of Dopamine D1 and D2 Receptors With Clozapine: Differentiation From Other Atypical Antipsychotics
Tauscher, J., Hussain, T., Agid, O., Verhoeff, N. P. L. G., Wilson, A. A., Houle, S., Remington, G., Zipursky, R. B., & Kapur, S. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.9.1620 · Cited by 159
Dietary Changes, Compulsions and Sexual Behavior in Frontotemporal Degeneration
Miller, B. L., Darby, A. L., Swartz, J. R., Yener, G., & Mena, I. G. (1995) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000106946 · Cited by 158
Rivastigmine in Frontotemporal Dementia
Moretti, R., Torre, P., Antonello, R. M., Cattaruzza, T., Cazzato, G., & Bava, A. (2004) · Drugs & Aging · doi:10.2165/00002512-200421140-00003 · Cited by 157
Neurochemical enzyme changes in Alzheimer's and Pick's disease
Meier‐Ruge, W., Iwangoff, P., & Reichlmeier, K. (1984) · Archives of Gerontology and Geriatrics · doi:10.1016/0167-4943(84)90007-4 · Cited by 147
Methylphenidate (‘Ritalin’) can Ameliorate Abnormal Risk-Taking Behavior in the Frontal Variant of Frontotemporal Dementia
Rahman, S., Robbins, T. W., Hodges, J. R., Mehta, M. A., Nestor, P. J., Clark, L., & Sahakian, B. J. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300886 · Cited by 136
The organization of serotonergic projections to cerebral cortex in primates: Retrograde transport studies
Wilson, M. A., & Molliver, M. E. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90077-2 · Cited by 133
The Distribution of Cerebral Muscarinic Acetylcholine Receptors In Vivo in Patients With Dementia
Weinberger, D. R. (1991) · Archives of Neurology · doi:10.1001/archneur.1991.00530140061018 · Cited by 129
Basal nucleus of meynert
Tagliavini, F., & Pilleri, G. (1983) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(83)90203-4 · Cited by 128
Neurochemical Features of Frontotemporal Dementia
PROCTER, A. W., Qurne, M., & Francis, P. T. (1999) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000051219 · Cited by 126
Theα 2 antagonist idazoxan remediates certain attentional and executive dysfunction in patients with dementia of frontal type
Coull, J. T., Sahakian, B. J., & Hodges, J. R. (1996) · Psychopharmacology · doi:10.1007/bf02246578 · Cited by 121
Mechanisms of antipsychotic-induced weight gain.
McIntyre, R. S., Mancini, D. A., & Basile, V. S. (2001) · PubMed · Cited by 119
Altered Serotonergic and Cholinergic Synaptic Markers in Pick's Disease
Sparks, D. L., & Markesbery, W. R. (1991) · Archives of Neurology · doi:10.1001/archneur.1991.00530200032014 · Cited by 112
Striatal dopamine transporter and extrapyramidal symptoms in frontotemporal dementia
Rinne, J. O., Laine, M., Kaasinen, V., Norvasuo‐Heilä, M., Någren, K., & Helenius, H. Y. M. (2002) · Neurology · doi:10.1212/wnl.58.10.1489 · Cited by 109
Neurons and Their Dendrites in Frontotemporal Dementia
Ferrer, I. (1999) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000051214 · Cited by 105
Efficacy of Fluvoxamine as a Treatment for Behavioral Symptoms in Frontotemporal Lobar Degeneration Patients
Ikeda, M., Shigenobu, K., Fukuhara, R., Hokoishi, K., Maki, N., Nebu, A., Komori, K., & Tanabe, H. (2004) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000076343 · Cited by 96
Olanzapine as a treatment of neuropsychiatric disorders of Alzheimer's disease and other dementias: A 24-month follow-up of 68 patients
Moretti, R., Torre, P., Antonello, R. M., Cazzato, G., Griggio, S., & Bava, A. (2003) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/153331750301800410 · Cited by 94
Vulnerability to neuroleptic side effects in frontotemporal lobar degeneration
Pijnenburg, Y. A. L., Sampson, E. L., Harvey, R. J., Fox, N. C., & Rossor, M. N. (2002) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.774 · Cited by 91
Alterations in Brain Monoamine Oxidase Activity in Aging, Alzheimer's Disease, and Pick's Disease
Sparks, D. L., Woeltz, V. M., & Markesbery, W. R. (1991) · Archives of Neurology · doi:10.1001/archneur.1991.00530190064017 · Cited by 89
Cortical Degeneration with Swollen Chromatolytic Neurons
Clark, A. W., Manz, H. J., White, C. L., Lehmann, J. C., Miller, D., & Coyle, J. T. (1986) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-198605000-00011 · Cited by 88
Frontotemporal dementia: evidence for impairment of ascending serotoninergic but not noradrenergic innervation
Yang, Y. M., & Schmitt, H. P. (2001) · Acta Neuropathologica · doi:10.1007/s004010000293 · Cited by 81
Decreased monoamine metabolites in frontotemporal dementia and Alzheimer’s disease
Sjögren, M. J. C., Minthon, L., Passant, U., Blennow, K., & Wallin, A. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(98)00086-4 · Cited by 81
A post-mortem comparison of the cortical cholinergic system in Alzheimer's disease and Pick's disease
Wood, P. L., Etienne, P. E., Lal, S., Nair, N. P. V., Finlayson, M. H., Gauthier, S. G., Palo, J., Haltia, M., Paetau, A. E., & Bird, E. D. (1983) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(83)90200-9 · Cited by 80
Goals in symptomatic pharmacologic management of frontotemporal lobar degeneration
Chow, T. W., & Mendez, M. F. (2002) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/153331750201700504 · Cited by 75
The Klüver-Bucy Syndrome in Man; pp. 65–83
Pilleri, G. (2008) · Psychiatria et Neurologia · doi:10.1159/000128232 · Cited by 71
Preliminary Neurochemical Findings in Non-Alzheimer Dementia due to Lobar Atrophy
Francis, P. T., Holmes, C. S., Webster, M.-T., Stratmann, G. C., PROCTER, A. W., & Bowen, D. M. (1993) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000107319 · Cited by 68
Neocortical morphometry and cholinergic neurochemistry in Pick's disease.
Hansen, L. A., DeTeresa, R. M., Tobias, H., Alford, M. F., & Terry, R. D. (1988) · PubMed Central · Cited by 64
Pick's disease (lobar sclerosis)
Uhl, G. R., Hilt, D. C., Hedreen, J. C., Whitehouse, P. J., & Price, D. L. (1983) · Neurology · doi:10.1212/wnl.33.11.1470 · Cited by 62
Case of Pick's Central Lobar Atrophy With Apparent Stabilization of Cognitive Decline After Treatment With Risperidone
Curtis, R., & Resch, D. S. (2000) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-200006000-00018 · Cited by 59
Calbindin D-28k and parvalbumin immunoreactivity in the frontal cortex in patients with frontal lobe dementia of non-Alzheimer type associated with amyotrophic lateral sclerosis.
Ferrer, I., Tuñón, T., Serrano, M. T., Casas, R., Alcántara, S., Zujar, M. J., & Rivera, R. (1993) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.56.3.257 · Cited by 52
Neurochemical observations in a case of Pick's disease
Yates, C. M., Simpson, J. A., Maloney, A. F. J., & Gordon, A. (1980) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(80)90205-1 · Cited by 50
Neuroimaging studies of schizophrenia
Pfefferbaum, A., & Zipursky, R. B. (1991) · Schizophrenia Research · doi:10.1016/0920-9964(91)90033-n · Cited by 50
Quantitative Electroencephalography in Frontotemporal Dementia with Methylphenidate Response: A Case Study
Goforth, H. W., Konopka, L. M., Primeau, M., Ruth, A., O'Donnell, K., Patel, R., Poprawski, T. J., Shirazi, P. H., & Rao, M. S. (2004) · Clinical EEG and Neuroscience · doi:10.1177/155005940403500212 · Cited by 46
The Klüver-Bucy Syndrome in man. A clinico-anatomical contribution to the function of the medial temporal lobe structures.
Pilleri, G. (1966) · PubMed · Cited by 46
Effects of selegiline on fronto‐temporal dementia: a neuropsychological evaluation
Moretti, R., Torre, P., Antonello, R. M., Cazzato, G., & Bava, A. (2002) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.602 · Cited by 44
Frontotemporal dementia
Kertesz, A., & Muñoz, D. G. (2002) · Medical Clinics of North America · doi:10.1016/s0025-7125(02)00011-1 · Cited by 43
Therapy and management of frontal lobe dementia patients
Litvan, I. (2001) · Neurology · doi:10.1212/wnl.56.suppl_4.s41 · Cited by 40
Efficacy of Cholinesterase Inhibitors in the Treatment of Neuropsychiatric Symptoms and Functional Impairment in Alzheimer Disease: A Meta-analysis
Trinh, N.-H., Hoblyn, J., Mohanty, S., & Yaffe, K. (2003) · JAMA · doi:10.1001/jama.289.2.210 · Cited by 37
Neurochemical and Histopathologic Alterations Characteristic of Pickʼs Disease in a Non-demented Individual
Sparks, D. L., Danner, F., Davis, D. G., Hackney, C., Landers, T. M., & Coyne, C. M. (1994) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199401000-00005 · Cited by 35
Studies on neurotransmitter markers of the basal ganglia in Pick's disease, with special reference to dopamine reduction
Kanazawa, I., Kwak, S., Sasaki, H., Muramoto, O., Mizutani, T., Hori, A., & Nukina, N. (1988) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(88)90020-2 · Cited by 35
Single photon emission computed tomography with [99Tc]-HM-PAO and [123I]-IBZM in Alzheimer's disease and dementia of frontal type: preliminary results
Frisoni, G. B., Pizzolato, G., Bianchetti, A., Chierichetti, F., Ferlin, G., Battistin, L., & Trabucchi, M. (2009) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1994.tb01661.x · Cited by 34
Imaging the serotonergic system in depression
D’Haenen, H. (2001) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/bf03035133 · Cited by 33
Evidence for an association between the CSF HVA:5-HIAA ratio and aggressiveness in frontotemporal dementia but not in Alzheimer's disease.
Engelborghs, S., Vloeberghs, E., Maertens, K., Marescau, B., & Deyn, P. P. D. (2004) · PubMed Central · Cited by 32
Efficacy of acetylcholinesterase inhibitors in frontotemporal dementia
Lampl, Y., Sadeh, M., & Lorberboym, M. (2004) · Annals of Pharmacotherapy · doi:10.1345/aph.1d445 · Cited by 30
Trazodone in the treatment of behaviour in frontotemporal dementia
Lebert, F., & Pasquier, F. (1999) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/(sici)1099-1077(199906)14:4 · Cited by 27
Bromocriptine Treatment for Perseveration in Demented Patients
Imamura, T., Takanashi, M., Hattori, N., Fujimori, M., Yamashita, H., Ishii, K., & Yamadori, A. (1998) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199806000-00009 · Cited by 26
Functional Imaging, the Frontal Lobes, and Dementia
Friedland, R. P., Koss, E., Lerner, A. J., Hedera, P., Ellis, W. G., Dronkers, N. F., Ober, B. A., & Jagust, W. J. (1993) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000107323 · Cited by 26
Amantadine for Executive Dysfunction Syndrome in Patients With Dementia
Drayton, S. J., Davies, K., Steinberg, M., Leroi, I., Rosenblatt, A., & Lyketsos, C. G. (2004) · Psychosomatics · doi:10.1176/appi.psy.45.3.205 · Cited by 26
A juvenile case of frontotemporal dementia: Neurochemical and neuropathological investigations
Nagaoka, S., Arai, H., Iwamoto, N., Ohwada, J., Ichimiya, Y., Nakamura, M., & Inoue, R. (1995) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(95)00264-2 · Cited by 22
Dementia, Religion, and Spirituality
Stuckey, J. C., & Gwyther, L. P. (2003) · Dementia · doi:10.1177/14713012030023001 · Cited by 20
Long-Term Care of Patients with Frontotemporal Dementia
Merrilees, J. J., & Miller, B. L. (2003) · Journal of the American Medical Directors Association · doi:10.1016/s1525-8610(04)70408-9 · Cited by 16
Alterations of muscarinic acetylcholine receptors in atypical Pick's disease without Pick bodies
Odawara, T. (2003) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.74.7.965 · Cited by 15
Biological Correlates of Clinical Subgroups of Alzheimer’s Disease
Sjögren, M. J. C., Wikkelsø, C., Östling, S., Wallin, A., & Blennow, K. (2002) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000066025 · Cited by 14
Functional imaging, the frontal lobes, and dementia
Friedland, R. P. (1998) · Neurocase · doi:10.1093/neucas/4.1.7-a · Cited by 11
Lack of cholinergic deficit in the neocortex in pick's disease
Wood, P. L., Nair, N. P. V., Etienne, P. E., Lal, S., Gauthier, S. G., ROBITAILLE, Y., Bird, E. D., Palo, J., Haltia, M., & Paetau, A. E. (1983) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(83)90053-2 · Cited by 9
Evidence for an association between the CSFHVA : 5-HIAA ratio and aggressiveness in frontotemporal dementia but not in Alzheimer's disease
Engelborghs, S. (2004) · VUBIR (Vrije Universiteit Brussel) · Cited by 9
Long-Term Care of Patients With Frontotemporal Dementia
Merrilees, J. J., & Miller, B. L. (2003) · Journal of the American Medical Directors Association · doi:10.1097/01.jam.0000095366.91533.22 · Cited by 8
Alterations in Tyrosine Hydroxylase Immunoreactive Neurons of the Locus ceruleus in Pick's Disease
Luque, J. M., & Chan-Palay, V. C. (1991) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000107220 · Cited by 5
Axonal loss in multiple sclerosis lesions: magnetic resonance imaging insights substrates of disability
Sperfeld (1999) · Pure Amsterdam UMC · doi:10.1002/1531-8249(199911)46:5 · Cited by 2

Sorted by citations

Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia
Rascovsky, K., Hodges, J. R., Knopman, D., Mendez, M. F., Kramer, J. H., Neuhaus, J., van Swieten, J. C., Seelaar, H., Dopper, E. G. P., Onyike, C. U., et al. (2011) · Brain · doi:10.1093/brain/awr179 · Cited by 5,221
Self-citation
Dementia and Cognitive Impairment
Hugo, J., & Ganguli, M. (2014) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2014.04.001 · Cited by 990
Frontotemporal Lobar Degeneration
Rabinovici, G. D., & Miller, B. L. (2010) · CNS Drugs · doi:10.2165/11533100-000000000-00000 · Cited by 518
EFNS‐ENS Guidelines on the diagnosis and management of disorders associated with dementia
Sorbi, S., Hort, J., Erkinjuntti, T., Fladby, T., Gainotti, G., Gurvit, H. I., Nacmias, B., Pasquier, F., Popescu, B. O., Rektorová, I., et al. (2012) · European Journal of Neurology · doi:10.1111/j.1468-1331.2012.03784.x · Cited by 328
Monoaminergic neuropathology in Alzheimer’s disease
Šimić, G., Leko, M. B., Wray, S., Harrington, C. R., Delalle, I., Milošević, N. J., Bažadona, D., Buée, L., de Silva, R., Giovanni, G. D., et al. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.04.001 · Cited by 297

See all 299

Authors: Huey, E. D., Putnam, K. T., & Grafman, J.
Affiliations: National Institutes of Health (US)
ORCID: Huey, Edward D.
Putnam, Karen T.
Grafman, Jordan
Venue: Neurology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2006-01-10
Volume: 66
Issue: 1
Pages: 17-22
ISSN: 0028-3878 (ISSN-L)
1526-632X
DOI: 10.1212/01.wnl.0000191304.55196.4d
PMC: PMC4499854
OpenAlex: W2148211031
Cited by: 299
References: 84
Citations by year: 2026: 12 · 2025: 11 · 2024: 9 · 2023: 12 · 2022: 11 · 2021: 20 · 2020: 10 · 2019: 14 · 2018: 11 · 2017: 16 · 2016: 20 · 2015: 10 · 2014: 15 · 2013: 18 · 2012: 17
FWCI: 2.50
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Neurology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of Neurological Disorders and Stroke (Z01NS002792)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
Keywords: frontotemporal dementia, neurotransmitter deficits, serotonin, dopamine, acetylcholine, antidepressants, behavioral symptoms, cognitive symptoms, treatment efficacy
MeSH terms: Antidepressive Agents, Brain, Clinical Trials as Topic, Dementia, Dopamine, Humans, Serotonin, Dopamine Agents, Treatment Outcome, Serotonin Receptor Agonists, Neurotransmitter Agents

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A systematic review of neurotransmitter deficits and treatments in frontotemporal dementia

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks