Cited by 299Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsAmyotrophic Lateral Sclerosis Research

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A systematic review of neurotransmitter deficits and treatments in frontotemporal dementia

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Huey, Edward D., Putnam, Karen T., Grafman, Jordan·2006·Neurology

DOI 10.1212/01.wnl.0000191304.55196.4dPMC PMC4499854

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Abstract

OBJECTIVE: To evaluate neurotransmitter deficiencies and neurotransmitter-based treatments for frontotemporal dementia (FTD). METHODS: The authors conducted a systematic review of the literature on the mechanism and treatment of FTD and a meta-analysis of treatment studies of antidepressants for the behavioral symptoms of FTD. RESULTS: Patients with FTD show deficiencies in the serotonin and dopamine neurotransmitter systems, while the acetylcholine system appears relatively intact. Antidepressant treatment significantly improves behavioral symptoms in FTD, but most studies are small and uncontrolled. Serotonergic treatments appear to improve the behavioral but not cognitive symptoms of FTD. CONCLUSIONS: Studies of neurotransmitter deficiencies in frontotemporal dementia (FTD) can be helpful in developing treatments. Treatment studies on FTD are scarce, given the prevalence and severity of this illness. Larger, well-controlled treatment studies are required to reach more definitive conclusions about treatment efficacy. Multicenter studies are likely the best way to complete treatment studies in a timely manner.

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[Japanese version of the Neuropsychiatric Inventory--a scoring system for neuropsychiatric disturbance in dementia patients].
Hirono, N., Mori, E., Ikejiri, Y., Imamura, T., Shimomura, T., Hashimoto, M., Yamashita, H., & Ikeda, M. (1997) · PubMed · Cited by 21,012
Special Care Units and Traditional Care in Dementia: Relationship with Behavior, Cognition, Functional Status and Quality of Life - A Review
Kok, J. S., Berg, I. J., & Scherder, E. J. A. (2013) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000353441 · Cited by 20,589
The Neuropsychiatric Inventory: Comprehensive assessment of psychopathology in dementia
Cummings, J. L., Mega, M., Gray, K., Rosenberg-Thompson, S., Carusi, D. A., & Gornbein, J. (1994) · Neurology · doi:10.1212/wnl.44.12.2308 · Cited by 7,568
Frontotemporal lobar degeneration: A consensus on clinical diagnostic criteria
Neary, D., Snowden, J. S., Gustafson, L., Passant, U., Stuss, D., Black, S., Freedman, M., Kertesz, A., Robert, P. H., Albert, M., et al. (1998) · Neurology · doi:10.1212/wnl.51.6.1546 · Cited by 5,047
Primary Progressive Aphasia
Weıntraub, S. (1990) · Archives of Neurology · doi:10.1001/archneur.1990.00530120075013 · Cited by 3,018
Clinical and neuropathological criteria for frontotemporal dementia. The Lund and Manchester Groups.
(1994) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.57.4.416 · Cited by 1,331
The prevalence of frontotemporal dementia
Ratnavalli, E., Brayne, C., Dawson, K. E., & Hodges, J. R. (2002) · Neurology · doi:10.1212/wnl.58.11.1615 · Cited by 1,182
Cerebral Glucose Metabolism in Adults with Hyperactivity of Childhood Onset
Zametkin, A. J., NORDAHL, T. E., Gross, M., King, A. C., Semple, W. E., Rumsey, J. M., Hamburger, S., & Cohen, R. M. (1990) · New England Journal of Medicine · doi:10.1056/nejm199011153232001 · Cited by 975
Pharmacological Treatment of Neuropsychiatric Symptoms of Dementia: A Review of the Evidence
Sink, K. M., Holden, K. F., & Yaffe, K. (2005) · JAMA · doi:10.1001/jama.293.5.596 · Cited by 910
Decreased β-Amyloid1-42and Increased Tau Levels in Cerebrospinal Fluid of Patients With Alzheimer Disease
Sunderland, T., Linker, G., Mirza, N., Putnam, K. T., Friedman, D. L., Kimmel, L. H., Bergeson, J., Manetti, G. J., Zimmermann, M., Tang, B., et al. (2003) · JAMA · doi:10.1001/jama.289.16.2094 · Cited by 656
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Cognitive and affective Theory of Mind in neurodegenerative diseases: Neuropsychological, neuroanatomical and neurochemical levels
Poletti, M., Enrici, I., & Adenzato, M. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.07.004 · Cited by 278
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Kayasuga, Y., Chiba, S., Suzuki, M., Kikusui, T., Matsuwaki, T., Yamanouchi, K., Kotaki, H., Horai, R., Iwakura, Y., & Nishihara, M. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.07.020 · Cited by 189
Galantamine in Frontotemporal Dementia and Primary Progressive Aphasia
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Current approaches in the treatment of Alzheimer's disease
Shah, R. S., Lee, H., Zhu, X., Perry, G. L., Smith, M. A., & Castellani, R. J. (2008) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2008.02.005 · Cited by 178
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An Evidence-Based Review of the Psychopathology of Frontotemporal Dementia: A Report of the ANPA Committee on Research
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Frontotemporal Lobar Degeneration: Epidemiology, Pathology, Diagnosis and Management
Seltman, R. E., & Matthews, B. R. (2012) · CNS Drugs · doi:10.2165/11640070-000000000-00000 · Cited by 132
Serotonergic Function and Treatment of Behavioral and Psychological Symptoms of Frontotemporal Dementia
Herrmann, N., Black, S. E., Chow, T. W., Cappell, J., Tang‐Wai, D. F., & Lanctôt, K. L. (2011) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e31823033f3 · Cited by 137
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Antonioni, A., Raho, E. M., Lopriore, P., Pace, A. P., Latino, R. R., Assogna, M., Mancuso, M., Gragnaniello, D., Granieri, E., Pugliatti, M., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411732 · Cited by 133
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Pressman, P., & Miller, B. L. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.11.006 · Cited by 127
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Frontotemporal dementia: therapeutic interventions.
Mendez, M. (2009) · Monographs in neural sciences · doi:10.1159/000197896 · Cited by 85
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Self-citation
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Self-citation
Frontotemporal dementia: a review for primary care physicians.
Cardarelli, R., Kertesz, A., & Knebl, J. A. (2010) · PubMed · Cited by 53
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Self-citation
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Wu, Z., Li, M., Fang, H., & Wang, B. (2012) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2012.09.060 · Cited by 41
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Coumarins: Auspicious Cholinesterase and Monoamine Oxidase Inhibitors
Orhan, İ. E., & Gülcan, H. O. (2015) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026615666150427113103 · Cited by 39
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Kundermann, B., Thum, A., Rocamora, R., Haag, A., Krieg, J.-C., & Hemmeter, U. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.07.008 · Cited by 38
Emerging Diagnostic and Therapeutic Strategies for Tauopathies
Coughlin, D. G., & Irwin, D. J. (2017) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-017-0779-1 · Cited by 42

Authors: Huey, E. D., Putnam, K. T., & Grafman, J.
Affiliations: National Institutes of Health (US)
ORCID: Huey, Edward D.
Putnam, Karen T.
Grafman, Jordan
Venue: Neurology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2006-01-10
Volume: 66
Issue: 1
Pages: 17-22
ISSN: 0028-3878 (ISSN-L)
1526-632X
DOI: 10.1212/01.wnl.0000191304.55196.4d
PMC: PMC4499854
OpenAlex: W2148211031
Cited by: 299
References: 84
Citations by year: 2026: 12 · 2025: 11 · 2024: 9 · 2023: 12 · 2022: 11 · 2021: 20 · 2020: 10 · 2019: 14 · 2018: 11 · 2017: 16 · 2016: 20 · 2015: 10 · 2014: 15 · 2013: 18 · 2012: 17
FWCI: 2.50
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Neurology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of Neurological Disorders and Stroke (Z01NS002792)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
Keywords: frontotemporal dementia, neurotransmitter deficits, serotonin, dopamine, acetylcholine, antidepressants, behavioral symptoms, cognitive symptoms, treatment efficacy
MeSH terms: Antidepressive Agents, Brain, Clinical Trials as Topic, Dementia, Dopamine, Humans, Serotonin, Dopamine Agents, Treatment Outcome, Serotonin Receptor Agonists, Neurotransmitter Agents

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A systematic review of neurotransmitter deficits and treatments in frontotemporal dementia

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