Syncope in migraine: The population-based CAMERA study
Abstract
OBJECTIVE: To examine the association between migraine and syncope-related autonomic nervous system (ANS) symptoms. METHODS: A population-based study among migraineurs with and without aura (n = 323) and control subjects (n = 153) was conducted. A systematic questionnaire and cardiovascular measurements during rest, while standing, and after venipuncture addressed the prevalence of syncope, orthostatic intolerance, orthostatic hypotension (OH), and the postural tachycardia syndrome (POTS) in migraineurs and control subjects. RESULTS: The lifetime prevalence of syncope in all participants was 41%, more often in women (45 vs 32%; p = 0.02). Compared with control subjects, migraineurs had a higher lifetime prevalence of syncope (46 vs 31%; p = 0.001), frequent syncope (five or more attacks) (13 vs 5%; p = 0.02), and orthostatic intolerance (32 vs 12%; p < 0.001). There was no association between ANS symptoms and the severity of migraine or migraine subtype. Cardiovascular measurements and the prevalence of POTS and OH did not differ significantly between migraineurs and control subjects. CONCLUSION: This population-based study demonstrated an elevated prevalence of syncope and orthostatic intolerance in migraineurs without clear interictal signs of autonomic nervous system dysfunction.
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Syncope, presumable VVS, and orthostatic intolerance occur more often in patients with migraine, who have a higher lifetime prevalence of syncope and often frequent syncope.
“Syncope, presumable VVS, and orthostatic intolerance occur more often in patients with migraine, who have a higher lifetime prevalence of syncope and often frequent syncope.”
From 2018 ESC Guidelines for the diagnosis and management of syncope (2018) · cites this paper as [426]
In migraineurs, syncope and migraine attacks rarely occur simultaneously.
“In migraineurs, syncope and migraine attacks rarely occur simultaneously.”
From 2018 ESC Guidelines for the diagnosis and management of syncope (2018) · cites this paper as [426]
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Developed in collaboration with, European Heart Rhythm Association (EHRA), Heart Failure Association (HFA), and Heart Rhythm Society (HRS), societies, E. B. T. F., European Society of Emergency Medicine (EuSEM), European Federation of Internal Medicine (EFIM), European Union Geriatric Medicine Society (EUGMS), American Geriatrics Society (AGS), European Neurological Society (ENS), et al. (2009) · European Heart Journal · doi:10.1093/eurheartj/ehp298 · Cited by 2,040 · see citing works
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- Authors
- Thijs, R. D., Kruit, M. C., van Buchem, M. A., Ferrari, M. D., Launer, L. J., & van Dijk, J. G.
- Affiliations
- National Institutes of Health (US)
- Venue
- Neurology
- Published
- 2006-04-11
- Volume
- 66
- Issue
- 7
- Pages
- 1034-1037
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2084287703
- Cited by
- 129
- References
- 29
- Citations by year
- 2025: 4 · 2024: 5 · 2023: 3 · 2022: 9 · 2021: 4 · 2020: 7 · 2019: 4 · 2018: 8 · 2017: 4 · 2016: 6 · 2015: 9 · 2014: 9 · 2013: 5 · 2012: 7
- FWCI
- 11.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Migraine and Headache Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cardiovascular and Diving-Related Complications
- Keywords
- syncope, migraine, orthostatic intolerance, orthostatic hypotension, postural orthostatic tachycardia syndrome, autonomic dysfunction, migraine with aura, prevalence, sex differences
- MeSH terms
- Blood Pressure, Brain, Educational Status, Female, Heart Rate, Humans, Hypotension, Orthostatic, Male, Middle Aged, Migraine Disorders, Posture, Surveys and Questionnaires, Reference Values, Syncope
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