The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Differences in neuropathologic characteristics across the Lewy body dementia spectrum
Open accessAbstract
BACKGROUND: The objective of this comparative neuropathologic study was to determine the extent to which dementia with Lewy bodies (DLB) and Parkinson disease dementia (PDD) are distinct entities or part of a continuum with respect to the duration of parkinsonism. METHODS: We evaluated the relationship between cortical alpha-synuclein pathology, plaques (Consortium to Establish a Registry for Alzheimer's Disease [CERAD]), tangles (Braak staging), and cholinergic deficits (choline acetyltransferase in temporal cortex) in 57 prospectively assessed patients (29 DLB, 28 PDD), confirmed at autopsy. The PDD group was divided according to the median duration of parkinsonism prior to dementia. RESULTS: There was an association between longer duration of parkinsonism prior to dementia and less severe cortical alpha-synuclein pathology (chi(2) 10.4, df 2, p = 0.006) and lower CERAD plaque scores (chi(2) 26.6, df 9, p = 0.002), but not Braak staging. These findings were confirmed in a further correlation analysis, which also identified an unexpected correlation between more pronounced cortical cholinergic deficits and longer duration of parkinsonism prior to dementia (R = -0.37, p = 0.04). CONCLUSION: While there is a clear relationship between the duration of Parkinson disease prior to the onset of dementia and key neuropathologic and neurochemical characteristics, there is a gradation of these differences across the dementia with Lewy bodies/Parkinson disease dementia spectrum and the findings do not support an arbitrary cut-off between the two disorders.
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Cites
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123
Parkinsonism: onset, progression, and mortality
Hoehn, M. M., & Yahr, M. D. (1967) · Neurology · doi:10.1212/wnl.17.5.427 · Cited by 12,107
Staging of brain pathology related to sporadic Parkinson’s disease
Braak, H., Tredici, K. D., Rüb, U., de Vos, R. A. I., Jansen Steur, E. N. H., & Braak, E. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00065-9 · Cited by 10,777
Diagnosis and management of dementia with Lewy bodies: Third report of the DLB consortium
McKeith, I. G., Dickson, D. W., Lowe, J., Emre, M., O'Brien, J. T., Feldman, H., Cummings, J., Duda, J. E., Lippa, C., Perry, E. K., et al. (2005) · Neurology · doi:10.1212/01.wnl.0000187889.17253.b1 · Cited by 5,069
Self-citationMirra, S. S., Heyman, A., McKeel, D., Sumi, S. M., Crain, B. J., Brownlee, L. M., Vogel, F. S., Hughes, J. P., Belle, G. V., Berg, L., et al. (1991) · Neurology · doi:10.1212/wnl.41.4.479 · Cited by 4,961
McKeith, I. G., Galasko, D., Kosaka, K., Perry, E. K., Dickson, D. W., Hansen, L. A., Salmon, D. P., Lowe, J., Mirra, S. S., Byrne, E. J., et al. (1996) · Neurology · doi:10.1212/wnl.47.5.1113 · Cited by 3,960
Self-citationDiagnostic Criteria for Parkinson Disease
Gelb, D. J., Oliver, E., & Gilman, S. (1999) · Archives of Neurology · doi:10.1001/archneur.56.1.33 · Cited by 2,822
Visual hallucinations in Lewy body disease relate to Lewy bodies in the temporal lobe
Harding, A., Broe, G. A., & Halliday, G. M. (2002) · Brain · doi:10.1093/brain/awf033 · Cited by 609
Senile dementia of Lewy body type
Perry, R. H., Irving, D., Blessed, G., FAIRBAIRN, A. F., & Perry, E. K. (1990) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(90)90236-g · Cited by 575
Self-citationParkinson Disease Neuropathology
Apaydın, H., Ahlskog, J. E., Parisi, J. E., Boeve, B. F., & Dickson, D. W. (2002) · Archives of Neurology · doi:10.1001/archneur.59.1.102 · Cited by 397
Neuropathology of dementia in Parkinson's disease: A prospective, community‐based study
Aarsland, D., Perry, R., Brown, A. D., Larsen, J. O., & Ballard, C. G. (2005) · Annals of Neurology · doi:10.1002/ana.20635 · Cited by 347
Self-citationCholinergic dysfunction in diseases with Lewy bodies
Tiraboschi, P., Hansen, L. A., Alford, M. F., Sabbagh, M. N., Schoos, B., Masliah, E., Thal, L. J., & Corey‐Bloom, J. (2000) · Neurology · doi:10.1212/wnl.54.2.407 · Cited by 332
Krüger, R., Vieira-Saecker, A. M. M., Kuhn, W., Berg, D., M�ller, T., K�hnl, N., Fuchs, G., Storch, A., Hungs, M., Woitalla, D., et al. (1999) · Annals of Neurology · doi:10.1002/1531-8249(199905)45:5 · Cited by 281
Frequency of Dementia in Parkinson Disease
Aarsland, D., Tandberg, E., Larsen, J. O., & Cummings, J. L. (1996) · Archives of Neurology · doi:10.1001/archneur.1996.00550060082020 · Cited by 276
Self-citationCholinergic Transmitter and Neurotrophic Activities in Lewy Body Dementia
Perry, E. K., Irving, D., Kerwin, J. M., McKeith, I. G., Thompson, P., Collerton, D., FAIRBAIRN, A. F., Ince, P. G., Morris, C. M., Cheng, A. V., et al. (1993) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199307020-00002 · Cited by 213
Self-citationTam, C. W. C., Burton, E. J., McKeith, I. G., Burn, D. J., & O’Brien, J. T. (2005) · Neurology · doi:10.1212/01.wnl.0000153070.82309.d4 · Cited by 209
Self-citationAre Parkinson’s Disease with dementia and Dementia with lewy Bodies the Same Entity?
Aarsland, D., Ballard, C. G., & Halliday, G. M. (2004) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988704267470 · Cited by 208
Self-citationLarsen, J. O., Dupont, E., & Tandberg, E. (2009) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1994.tb01674.x · Cited by 176
Self-citationDementia with Lewy bodies and Parkinson's disease with dementia: Are they different?
Tsuboi, Y., & Dickson, D. W. (2005) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2004.10.014 · Cited by 155
Ouchi, Y., Yoshikawa, E., Okada, H., Futatsubashi, M., Sekine, Y., Iyo, M., & Sakamoto, M. (1999) · PubMed · Cited by 145
Katsuse, O., Iseki, E., Marui, W., & Kosaka, K. (2003) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(03)00037-6 · Cited by 98
A paced visual serial addition test for fMRI
Lazeron, R. H. C., Rombouts, S. A. R. B., de Sonneville, L. M. J., Barkhof, F., & Scheltens, P. (2003) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(03)00144-8 · Cited by 90
The present state of people who survived the holocaust as children
Robinson, S., Rapaport‐Bar‐Sever, M., & Rapaport, J. (1994) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1994.tb01508.x · Cited by 87
Parkinson's disease and dementia with Lewy bodies: One disease or two?
Richard, I. H., Papka, M., Rubio, A. I., & Kurlan, R. (2002) · Movement Disorders · doi:10.1002/mds.10274 · Cited by 65
Iseki, E. (2004) · Neuropathology · doi:10.1111/j.1440-1789.2003.00530.x · Cited by 54
Non‐uniformity in the regional pattern of Lewy pathology in brains of dementia with Lewy bodies
Yamamoto, R., Iseki, E., Marui, W., Togo, T., Katsuse, O., Kato, M., Isojima, D., Akatsu, H., Kosaka, K., & Arai, H. (2005) · Neuropathology · doi:10.1111/j.1440-1789.2005.00627.x · Cited by 31
Rodrigo, J., Fernández, A. P., Bentura, M. L., de Velasco, J. M., Serrano, J., UTTENTHAL, L. O., & Martínez‐Murillo, R. (1998) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(98)00016-7 · Cited by 29
Torres, E. M., Rogers, D. C., Annett, L. E., SIRINATHSINGHJI, D. J. S., & Dunnett, S. B. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90100-y · Cited by 20
Research works printed but not linked: 3
- Emre M. Dementia associated with Parkinson's disease. Lancet Neurol 2003;2:229–237.
- Perry RH Jaros E Hall RA et al. Proposal for modification of consensus guidelines for the neuropathological diagnosis of dementia with Lewy bodies (DLB) when using alfa-synuclein IHC. Third International Workshop on Dementia with Lewy Bodies and Parkinson's Disease. Dementia. Vol. 158. Newcastle upon Tyne UK 2003;158.
- Lippa SM, Lippa CF, Mori H. Alpha-synuclein aggregation in pathological aging and Alzheimer's disease: the impact of beta-amyloid plaque level. Am J Alzheimers Dis Other Dement 2005;20:315–318.
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Emre, M., Aarsland, D., Brown, R., Burn, D. J., Duyckaerts, C., Mizuno, Y., Broe, G. A., Cummings, J., Dickson, D. W., Gauthier, S., et al. (2007) · Movement Disorders · doi:10.1002/mds.21507 · Cited by 3,027
Self-citationLees, A. J., Hardy, J., & Revesz, T. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60492-x · Cited by 1,956
Cognitive decline in Parkinson disease
Aarsland, D., Creese, B., Politis, M., Chaudhuri, K. R., ffytche, D. H., Weintraub, D., & Ballard, C. (2017) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.27 · Cited by 1,027
Self-citationNeuropathological assessment of Parkinson’s disease: refining the diagnostic criteria
Dickson, D. W., Braak, H., Duda, J. E., Duyckaerts, C., Gasser, T., Halliday, G. M., Hardy, J., Leverenz, J. B., Del Tredici, K., Wszolek, Z. K., et al. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70238-8 · Cited by 972
Kehagia, A. A., Barker, R. A., & Robbins, T. W. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70212-x · Cited by 928
Metadata
- Authors
- Ballard, C., Ziabreva, I., Perry, R., Larsen, J. P., O'Brien, J., McKeith, I., Perry, E., & Aarsland, D.
- Affiliations
- King's College London (GB)
- From the Wolfson Centre for Age-Related Diseases (C.B.), Wolfson Building, Guy's Campus, King's College London, UK; Institute of Ageing and Health (I.Z., R.P., J.O., I.M., E.P.), Newcastle General Hospital, Newcastle upon Tyne, UK; and Norwegian Center for Movement Disorders (J.P.L., D.A.), Stavanger University Hospital, Stavanger, Norway.
- Venue
- Neurology
- Published
- 2006-12-12
- Volume
- 67
- Issue
- 11
- Pages
- 1931-1934
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2107172544
- Cited by
- 335
- References
- 28
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 9 · 2023: 9 · 2022: 12 · 2021: 11 · 2020: 16 · 2019: 23 · 2018: 23 · 2017: 15 · 2016: 16 · 2015: 13 · 2014: 21 · 2013: 25 · 2012: 28
- FWCI
- 12.73
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- dementia with Lewy bodies, Parkinson's disease dementia, alpha-synuclein pathology, Braak staging, cholinergic deficit, choline acetyltransferase, differential diagnosis, neuropathology
- MeSH terms
- Aged, Aged, 80 and over, Choline O-Acetyltransferase, Female, Humans, Male, Parkinson Disease, Prospective Studies, Temporal Lobe, Time Factors, Neurofibrillary Tangles, Lewy Body Disease, alpha-Synuclein, Plaque, Amyloid
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