Temporal lobe atrophy on MRI in Parkinson disease with dementia: a comparison with Alzheimer disease and dementia with Lewy bodies
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Objective To investigate the extent of medial temporal lobe atrophy (MTA) on MRI in Parkinson disease (PD) with and without dementia compared with Alzheimer disease (AD) and dementia with Lewy bodies (DLB) and to determine whether MTA correlates with cognitive impairment in PD and PD dementia (PDD). Methods Coronal T1-weighted MRI scans were acquired from control subjects (n = 39) and patients with PD (n = 33), PDD (n = 31), DLB (n = 25), and AD (n = 31), diagnosed according to standardized clinical diagnostic criteria. Cognitive function was assessed using the Cambridge Cognitive Examination (CAMCOG), and MTA was rated visually using a standardized (Scheltens) scale. Results More severe MTA was seen in PDD (p = 0.007), DLB (p Conclusions Medial temporal lobe atrophy (MTA) was seen in cognitively intact older subjects with Parkinson disease (PD) and was not more pronounced in Parkinson disease dementia (PDD). Alzheimer disease (AD) and, to a lesser extent, dementia with Lewy bodies (DLB) showed more pronounced MTA. Results suggest early hippocampal involvement in PD and that when dementia develops in PD, anatomic structures apart from the hippocampus are predominantly implicated. Greater hippocampal involvement in AD vs PDD and DLB is consistent with clinical, cognitive, and pathologic differences between the disorders.
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MTA may also be present in other types of dementia and absence of MTA does not exclude the diagnosis of AD especially in the early stage.
“However, MTA may also be present in other types of dementia (Tam et al., 2005; Barber et al., 1999) and absence of MTA does not exclude the diagnosis of AD especially in the early stage.”
From T1rho MRI and CSF biomarkers in diagnosis of Alzheimer's disease (2015) · cites this paper as Tam et al., 2005
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- Authors
- Tam, C. W. C., Burton, E. J., McKeith, I. G., Burn, D. J., & O’Brien, J. T.
- Affiliations
- Tai Po Hospital (CN)
- From the Department of Psychiatry (Dr. Tam), Tai Po Hospital, Hong Kong; and Institute for Ageing and Health (Drs. Burton, McKeith, and O’Brien), University of Newcastle upon Tyne, and Department of Neurology (Dr. Burn), Regional Neurosciences Centre, Newcastle General Hospital, UK.
- Venue
- Neurology
- Published
- 2005-03-08
- Volume
- 64
- Issue
- 5
- Pages
- 861-865
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2024369842
- Cited by
- 209
- References
- 3
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 3 · 2023: 6 · 2022: 7 · 2021: 3 · 2020: 4 · 2019: 8 · 2018: 10 · 2017: 13 · 2016: 8 · 2015: 12 · 2014: 11 · 2013: 12 · 2012: 15
- FWCI
- 8.40
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Keywords
- Parkinson's disease, Parkinson's disease dementia, medial temporal lobe atrophy, hippocampal atrophy, dementia with Lewy bodies, Alzheimer's disease, cognitive impairment, memory, brain atrophy, differential diagnosis of dementia
- MeSH terms
- Age Factors, Aged, Aged, 80 and over, Aging, Alzheimer Disease, Atrophy, Cognition Disorders, Female, Hippocampus, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Parkinson Disease, Predictive Value of Tests, Prospective Studies, Temporal Lobe, Disease Progression, Lewy Body Disease
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