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Cognitive decline in Alzheimer disease: Impact of spirituality, religiosity, and QOL
Abstract
OBJECTIVE: To assess effects of quality of life (QOL), spirituality, and religiosity on rate of progression of cognitive decline in Alzheimer disease (AD). METHODS: In this longitudinal study, we recruited 70 patients with probable AD. The Mini-Mental State Examination was used to monitor the rate of cognitive decline. Religiosity and spirituality were measured using standardized scales that assess spirituality, religiosity, and organizational and private religious practices. We conducted a simultaneous multiple linear regression analysis for factors contributing to rate of cognitive decline. RESULTS: After controlling for baseline level of cognition, age, sex, and education, a slower rate of cognitive decline was associated with higher levels of spirituality (p < 0.05) and private religious practices (p < 0.005). These variables accounted for 17% of the total variance [F(11,58) = 2.24, p < 0.05]. There was no correlation between rate of cognitive decline and QOL. CONCLUSION: Higher levels of spirituality and private religious practices, but not quality of life, are associated with slower progression of Alzheimer disease.
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“Physiological changes that occur with stress and depression (elevated blood cortisol, in particular) are known to adversely affect the parts of the brain responsible for memory [419–421].”
From Religion, Spirituality, and Health: The Research and Clinical Implications (2012) · cites this paper as [419]
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Metadata
- Authors
- Kaufman, Y., Anaki, D., Binns, M., & Freedman, M.
- Affiliations
- Mount Sinai Hospital (CA)
- Venue
- Neurology
- Published
- 2007-05
- Volume
- 68
- Issue
- 18
- Pages
- 1509-1514
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2086822026
- Cited by
- 109
- References
- 50
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 7 · 2023: 3 · 2022: 5 · 2021: 8 · 2020: 6 · 2019: 4 · 2018: 12 · 2017: 9 · 2016: 6 · 2015: 7 · 2014: 4 · 2013: 6 · 2012: 6
- FWCI
- 2.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Health › Religion, Spirituality, and Psychology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease, cognitive decline, spirituality, religiosity, private religious practice, quality of life, disease progression, religious coping
- MeSH terms
- Adaptation, Psychological, Aged, Aged, 80 and over, Alzheimer Disease, Cognition Disorders, Female, Humans, Longitudinal Studies, Male, Middle Aged, Neuropsychological Tests, Quality of Life, Regression Analysis, Religion and Psychology, Disease Progression, Spirituality
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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