CoChat
Sign Up
Cited by 230Parkinson's Disease Mechanisms and TreatmentsBalance, Gait, and Falls PreventionPhysical Activity and Health

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

Phase I/II randomized trial of aerobic exercise in Parkinson disease in a community setting

Open access
Uc, Ergun Y., Doerschug, Kevin C., Magnotta, Vincent, Dawson, Jeffrey D., Thomsen, Teri R., Kline, Joel N., Rizzo, Matthew, Newman, Sara R., Mehta, Sonya, Grabowski, Thomas J., Bruss, Joel, Blanchette, Derek R., Anderson, Steven W., Voss, Michelle W., Kramer, Arthur F., Darling, Warren G.·2014·Neurology
DOI 10.1212/wnl.0000000000000644PMC PMC4132568
Open this paper in CoChat — free accountOpen PDF

Abstract

OBJECTIVES: To (1) investigate effects of aerobic walking on motor function, cognition, and quality of life in Parkinson disease (PD), and (2) compare safety, tolerability, and fitness benefits of different forms of exercise intervention: continuous/moderate intensity vs interval/alternating between low and vigorous intensity, and individual/neighborhood vs group/facility setting. METHODS: Initial design was a 6-month, 2 × 2 randomized trial of different exercise regimens in independently ambulatory patients with PD. All arms were required to exercise 3 times per week, 45 minutes per session. RESULTS: Randomization to group/facility setting was not feasible because of logistical factors. Over the first 2 years, we randomized 43 participants to continuous or interval training. Because preliminary analyses suggested higher musculoskeletal adverse events in the interval group and lack of difference between training methods in improving fitness, the next 17 participants were allocated only to continuous training. Eighty-one percent of 60 participants completed the study with a mean attendance of 83.3% (95% confidence interval: 77.5%-89.0%), exercising at 46.8% (44.0%-49.7%) of their heart rate reserve. There were no serious adverse events. Across all completers, we observed improvements in maximum oxygen consumption, gait speed, Unified Parkinson's Disease Rating Scale sections I and III scores (particularly axial functions and rigidity), fatigue, depression, quality of life (e.g., psychological outlook), and flanker task scores (p < 0.05 to p < 0.001). Increase in maximum oxygen consumption correlated with improvements on the flanker task and quality of life (p < 0.05). CONCLUSIONS: Our preliminary study suggests that aerobic walking in a community setting is safe, well tolerated, and improves aerobic fitness, motor function, fatigue, mood, executive control, and quality of life in mild to moderate PD. CLASSIFICATION OF EVIDENCE: This study provides Class IV evidence that in patients with PD, an aerobic exercise program improves aerobic fitness, motor function, fatigue, mood, and cognition.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1212/wnl.0000000000000644

Cites

40 of 40 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 40 references

Cited by

Sorted by citations

Items 101–200 of 230

Related

See all

Metadata

Authors
Uc, E. Y., Doerschug, K. C., Magnotta, V., Dawson, J. D., Thomsen, T. R., Kline, J. N., Rizzo, M., Newman, S. R., Mehta, S., Grabowski, T. J., Bruss, J., Blanchette, D. R., Anderson, S. W., Voss, M. W., Kramer, A. F., & Darling, W. G.
Affiliations
University of Iowa (US)
ORCID
Venue
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2014-07-29
Volume
83
Issue
5
Pages
413-425
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
DOI
10.1212/wnl.0000000000000644
PMC
PMC4132568
OpenAlex
W1976513341
Cited by
230
References
40
Citations by year
2026: 10 · 2025: 21 · 2024: 14 · 2023: 11 · 2022: 20 · 2021: 19 · 2020: 19 · 2019: 26 · 2018: 21 · 2017: 21 · 2016: 20 · 2015: 22 · 2014: 4
FWCI
14.55
Type
journal article
Language
en
Open access
Locations
  • Neurology (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute on Aging (R01AG017177)
  • National Institute of Neurological Disorders and Stroke (R01NS044930)
  • National Institute of Environmental Health Sciences (ES005605, P30ES005605)
  • National Center for Research Resources (UL1RR024979)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Balance, Gait, and Falls Prevention
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
Keywords
Parkinson's disease, aerobic exercise, aerobic walking, interval training, continuous training, cardiorespiratory fitness, motor function, fatigue, depression, executive function, quality of life, community-based exercise, walking speed, VO2max
MeSH terms
Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Parkinson Disease, Quality of Life, Residence Characteristics, Exercise, Treatment Outcome

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review