The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Mindfulness-based therapy for drug-resistant epilepsy: An assessor-blinded randomized trial
Abstract
OBJECTIVE: To investigate the effectiveness of mindfulness-based therapy (MT) and social support (SS) in patients with drug-resistant epilepsy. METHODS: We performed an assessor-blinded randomized control trial. Sixty patients with drug-resistant epilepsy were randomly allocated to MT or SS (30 per group). Each group received 4 biweekly intervention sessions. The primary outcome was the change in the total score of the Patient-Weighted Quality of Life in Epilepsy Inventory (QOLIE-31-P). Secondary outcomes included seizure frequency, mood symptoms, and neurocognitive functions. The assessors were blinded to the patient's intervention grouping. Results were analyzed using general linear model with repeated measure. RESULTS: Following intervention, both the MT (n=30) and SS (n=30) groups had an improved total QOLIE-31-P, with an improvement of +6.23 for MT (95% confidence interval [CI] +4.22 to +10.40) and +3.30 for SS (95% CI +1.03 to +5.58). Significantly more patients in the MT group had a clinically important improvement in QOLIE-31-P (+11.8 or above) compared to those who received SS (11 patients vs 4 patients). Significantly greater reduction in depressive and anxiety symptoms, seizure frequency, and improvement in delayed memory was observed in the MT group compared with the SS group. CONCLUSIONS: We found benefits of short-term psychotherapy on patients with drug-resistant epilepsy. Mindfulness therapy was associated with greater benefits than SS alone in quality of life, mood, seizure frequency, and verbal memory. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that mindfulness-based therapy significantly improves quality of life in patients with drug-resistant epilepsy.
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“Seizure-related parameters (eg, minimum seizure frequency) constituted an inclusion criterion in 6 studies (25%; see Table 1). 33 -37,47”
From Cochrane systematic review and meta-analysis of the impact of psychological treatments for people with epilepsy on health-related quality of life (2018) · cites this paper as [36]
In the citing paper
“Four studies (17%) 34 -36,39 managed to blind the participants in both the treatment group and the active control group by telling them that they would participate in an intervention to improve coping with epilepsy.”
From Cochrane systematic review and meta-analysis of the impact of psychological treatments for people with epilepsy on health-related quality of life (2018) · cites this paper as [36]
In the citing paper
“It was used in 17 studies (71%), of which 12 (70%) were considered for meta-analyses due to satisfactory methodological homogeneity. 26,27,29,30,33,36,37,41,46,47,49,50”
From Cochrane systematic review and meta-analysis of the impact of psychological treatments for people with epilepsy on health-related quality of life (2018) · cites this paper as [36]
In the citing paper
“A rating of low ROB was confirmed based on document review of registered protocols provided by the authors for 9 studies (37%). 32,36,40,42,44 -46,49,50”
From Cochrane systematic review and meta-analysis of the impact of psychological treatments for people with epilepsy on health-related quality of life (2018) · cites this paper as [36]
In the citing paper
“Eight studies (33%) 27,29,36,38,39,44,48,49 were rated as low risk as there was only a small number of missing data, which were balanced across the groups with justifiable reasons.”
From Cochrane systematic review and meta-analysis of the impact of psychological treatments for people with epilepsy on health-related quality of life (2018) · cites this paper as [36]
In the citing paper
“Consequently, the meta-analysis comprised data from 9 studies (37%) 26 -30,33,36,46,49,50 with a total of 468 participants (see studies highlighted in gray in Table 1).”
From Cochrane systematic review and meta-analysis of the impact of psychological treatments for people with epilepsy on health-related quality of life (2018) · cites this paper as [36]
In the citing paper
“Seven studies (64%) reported a significant postintervention difference between the intervention and the control groups. 26 -29,31,32,36,46”
From Cochrane systematic review and meta-analysis of the impact of psychological treatments for people with epilepsy on health-related quality of life (2018) · cites this paper as [36]
In the citing paper
“The most commonly used scale was the Beck Depression Inventory/Beck Depression Inventory-II, which was used in 5 studies (45%). 29 -32,36”
From Cochrane systematic review and meta-analysis of the impact of psychological treatments for people with epilepsy on health-related quality of life (2018) · cites this paper as [36]
In the citing paper
“A total of 5 studies (21%) included anxiety level as an outcome measure 28,30,36,43,46 ; all of them reported no significant baseline difference between the treatment and control groups.”
From Cochrane systematic review and meta-analysis of the impact of psychological treatments for people with epilepsy on health-related quality of life (2018) · cites this paper as [36]
In the citing paper
“The percentage of participants whose results reached MIC was only provided in 1 study. 36”
From Cochrane systematic review and meta-analysis of the impact of psychological treatments for people with epilepsy on health-related quality of life (2018) · cites this paper as [36]
In the citing paper
“Three studies (33%) reported a significantly greater reduction of seizure frequency in the treatment compared to the control group at postintervention, 34,36,40”
From Cochrane systematic review and meta-analysis of the impact of psychological treatments for people with epilepsy on health-related quality of life (2018) · cites this paper as [36]
In the citing paper
“Blinding of participants was performed in only 4 studies. 34 -36,39”
From Cochrane systematic review and meta-analysis of the impact of psychological treatments for people with epilepsy on health-related quality of life (2018) · cites this paper as [36]
Citations
Cites
Statistical Power Analysis for the Behavioral Sciences
Muller, K. E., & Cohen, J. (1989) · Technometrics · doi:10.2307/1270020 · Cited by 99,603
Statistical power analysis for the behavioral sciences
Cohen, J. (1990) · Computers Environment and Urban Systems · doi:10.1016/0198-9715(90)90050-4 · Cited by 65,417
Lakens, D. (2013) · Frontiers in Psychology · doi:10.3389/fpsyg.2013.00863 · Cited by 10,303
Mindfulness-based interventions in context: Past, present, and future
Kabat-Zinn, J. (2003) · Clinical Psychology: Science and Practice · doi:10.1093/clipsy.bpg016 · Cited by 8,615 · cited 2×
“The MT protocol was designed based on several guiding references on mindfulness.(6,9,21,22) We emphasized the concept of mind–body connection that has been rooted in the Chinese culture.”
BackgroundMethodMindfulness-based interventions in context: Past, present, and future.
Kabat-Zinn, J. (2003) · Clinical Psychology: Science and Practice · doi:10.1093/clipsy/bpg016 · Cited by 8,612
Kwan, P., Arzimanoglou, A. A., Berg, A. T., Brodie, M. J., Hauser, W. A., Mathern, G. W., Moshé, S. L., Perucca, E., Wiebe, S., & French, J. A. (2009) · Epilepsia · doi:10.1111/j.1528-1167.2009.02397.x · Cited by 4,918
Self-citationThe effect of mindfulness based therapy on anxiety and depression: A meta analytic review
Hofmann, S. G., Sawyer, A. T., Witt, A. A., & Oh, D. (2010) · Journal of Consulting and Clinical Psychology · doi:10.1037/a0018555 · Cited by 3,846
Hölzel, B. K., Lazar, S. W., Gard, T., Schuman-Olivier, Z., Vago, D. R., & Ott, U. (2011) · Perspectives on Psychological Science · doi:10.1177/1745691611419671 · Cited by 3,024
Alterations in brain and immune function produced by mindfulness meditation
Davidson, R. J., Kabat-Zinn, J., Schumacher, J., Rosenkranz, M., Muller, D., Santorelli, S. F., Urbanowski, F., Harrington, A., Bonus, K., & Sheridan, J. F. (2003) · Psychosomatic Medicine · doi:10.1097/01.psy.0000077505.67574.e3 · Cited by 2,925
Mindfulness practice leads to increases in regional brain gray matter density
Hölzel, B. K., Carmody, J., Vangel, M., Congleton, C., Yerramsetti, S. M., Gard, T., & Lazar, S. W. (2011) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2010.08.006 · Cited by 1,914
Flagged first, then by citations
Research works printed but not linked: 1
- Dahl J, Lundgren T. Analysis and treatment of epilepsy using mindfulness, acceptance, values, and countermeasures. In: , McCracken LM, editor. Mindfulness and Acceptance in Behavioral Medicine. Oakland, CA: New Harbinger Publications; 2011.
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Whitfield, T. J., Barnhofer, T., Acabchuk, R. L., Cohen, A., Lee, M., Schlosser, M., Arenaza‐Urquijo, E. M., Böttcher, A., Britton, W. B., Coll‐Padrós, N., et al. (2021) · Neuropsychology Review · doi:10.1007/s11065-021-09519-y · Cited by 247
Michaelis, R., Tang, V., Goldstein, L. H., Reuber, M., LaFrance, W. C., Lundgren, T., Modi, A. C., & Wagner, J. L. (2018) · Epilepsia · doi:10.1111/epi.14444 · Cited by 167
Self-citationClinical Management of Drug Resistant Epilepsy: A Review on Current Strategies
Guery, D., & Rheims, S. (2021) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s256699 · Cited by 165
“Mindfulness therapy is also associated with greater benefits than short-term psychotherapy in QOL, mood, seizure frequency, and verbal memory.(147)”
BackgroundThe Relationship Between Epilepsy and Anxiety Disorders
Hingray, C., McGonigal, A., Kotwas, I., & Micoulaud‐Franchi, J. (2019) · Current Psychiatry Reports · doi:10.1007/s11920-019-1029-9 · Cited by 146
Michaelis, R., Tang, V., Wagner, J. L., Modi, A. C., LaFrance, W. C., Goldstein, L. H., Lundgren, T., & Reuber, M. (2018) · Epilepsia · doi:10.1111/epi.13989 · Cited by 122
Self-citation
Metadata
- Authors
- Tang, V., Poon, W. S., & Kwan, P.
- Affiliations
- The Royal Melbourne Hospital (AU)
- Venue
- Neurology
- Published
- 2015-09-29
- Volume
- 85
- Issue
- 13
- Pages
- 1100-1107
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W1664254336
- Cited by
- 116
- References
- 36
- Citations by year
- 2026: 6 · 2025: 2 · 2024: 6 · 2023: 5 · 2022: 4 · 2021: 12 · 2020: 11 · 2019: 38 · 2018: 12 · 2017: 10 · 2016: 8 · 2015: 2
- FWCI
- 13.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
- Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Keywords
- mindfulness-based interventions, drug-resistant epilepsy, social support, quality of life, seizure frequency, depressive symptoms, anxiety symptoms, verbal memory, mood, psychotherapy
- MeSH terms
- Adult, Drug Resistance, Epilepsy, Female, Humans, Male, Middle Aged, Psychotherapy, Group, Quality of Life, Social Support, Single-Blind Method, Treatment Outcome, Mindfulness
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