The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Comorbidity in multiple sclerosis is associated with diagnostic delays and increased mortality
Abstract
Objective To investigate the effect of chronic comorbidity on the time of diagnosis of multiple sclerosis (MS) and on mortality in MS. Methods We conducted a population-based, nationwide cohort study including all incident MS cases in Denmark with first MS symptom between 1980 and 2005. To investigate the time of diagnosis, we compared individuals with and without chronic comorbidity using multinomial logistic regression. To investigate mortality, we used Cox regression with time-dependent covariates, following study participants from clinical MS onset until endpoint (death) or to the end of the study, censuring at emigration. Results We identified 8,947 individuals with clinical onset of MS between 1980 and 2005. In the study of time of diagnosis, we found statistically significant odds ratios for longer diagnostic delays with cerebrovascular comorbidity (2.01 [1.44-2.80]; Conclusions An increased awareness of both the necessity of neurologic evaluation of new neurologic symptoms in persons with preexisting chronic disease and of optimum treatment of comorbidity in MS is critical.
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“A nationwide cohort study in Denmark did not find a statistically significant increase in diagnostic delay in patients with psychiatric comorbidity, perhaps due to a small number of patients (n = 75), but there was a significantly increased mortality [55].”
From Functional neurological disorder and multiple sclerosis: a systematic review of misdiagnosis and clinical overlap (2022) · cites this paper as [55]
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Cites
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Walzl, D., Solomon, A. J., & Stone, J. (2022) · Journal of Neurology · doi:10.1007/s00415-021-10436-6 · Cited by 62
Metadata
- Authors
- Thormann, A., Sørensen, P. S., Koch-Henriksen, N., Laursen, B., & Magyari, M.
- Affiliations
- University of Copenhagen (DK)
- From the Danish Multiple Sclerosis Center (A.T., P.S.S., M.M.), Department of Neurology, University of Copenhagen, Rigshospitalet; The Danish Multiple Sclerosis Registry (A.T., N.K.-H., M.M.), Department of Neurology, Rigshospitalet, Copenhagen; Department of Clinical Epidemiology (N.K.-H.), Clinical Institute, University of Aarhus; and The Danish National Institute of Public Health (B.L.), University of Southern Denmark, Copenhagen.
- Venue
- Neurology
- Published
- 2017-10-17
- Volume
- 89
- Issue
- 16
- Pages
- 1668-1675
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2755369012
- Cited by
- 102
- References
- 1
- Citations by year
- 2026: 12 · 2025: 15 · 2024: 12 · 2023: 15 · 2022: 9 · 2021: 15 · 2020: 11 · 2019: 7 · 2018: 6
- FWCI
- 5.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Epidemiology › Chronic Disease Management Strategies
- Health Sciences › Medicine › Family Practice › Clinical Reasoning and Diagnostic Skills
- Keywords
- multiple sclerosis, chronic comorbidities, delayed diagnosis, mortality, cardiovascular comorbidity, diabetes mellitus, cancer, psychiatric comorbidity, Parkinson's disease, incident cases, Denmark, neurological examination, quality of life, disability progression, disease-modifying therapy, medication adherence
- MeSH terms
- Adult, Autoimmune Diseases, Cardiovascular Diseases, Cerebrovascular Disorders, Denmark, Female, Humans, Kidney Diseases, Male, Middle Aged, Multiple Sclerosis, Neoplasms, Neurologic Examination, Parkinson Disease, Time Factors, Cohort Studies, Comorbidity, Logistic Models, Community Health Planning, Mood Disorders, Young Adult, Delayed Diagnosis
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