The DOI matches its Crossref record; 40 of the 41 references it cites were found in a registry or an index.
Regional oxygen extraction predicts border zone vulnerability to stroke in sickle cell disease
Open accessAbstract
OBJECTIVE: ) in children with SCD. METHODS: . An infarct heat map was created from an independent pediatric SCD cohort with silent infarcts and compared to prospectively obtained OEF maps. RESULTS: < 0.001). Furthermore, this peak OEF region colocalized with regions of greatest infarct density derived from an independent SCD cohort. CONCLUSIONS: Elevated OEF in the deep white matter identifies a signature of metabolically stressed brain tissue at increased stroke risk in pediatric patients with SCD. We propose that border zone physiology, exacerbated by chronic anemic hypoxia, explains the high risk in this region.
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“the oxygen extraction fraction is also increased at baseline (139, 140).”
From Pathophysiology of Sickle Cell Disease (2019) · cites this paper as [139]
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Research works printed but not linked: 1
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Pathophysiology of Sickle Cell Disease
Sundd, P., Gladwin, M. T., & Novelli, E. M. (2019) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-012418-012838 · Cited by 813
Ford, A. L., Ragan, D. K., Fellah, S., Binkley, M. M., Fields, M. E., Guilliams, K. P., An, H., Jordan, L. C., McKinstry, R. C., Lee, J., et al. (2018) · Blood · doi:10.1182/blood-2018-04-841247 · Cited by 118
Self-citationGuilliams, K. P., Fields, M. E., Ragan, D. K., Eldeniz, C., Binkley, M. M., Chen, Y., Comiskey, L., Doctor, A., Hulbert, M. L., Shimony, J. S., et al. (2017) · Blood · doi:10.1182/blood-2017-06-789842 · Cited by 101
Self-citationHydroxyurea reduces cerebral metabolic stress in patients with sickle cell anemia
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Self-citationWhite matter integrity and processing speed in sickle cell anemia
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Metadata
- Authors
- Fields, M. E., Guilliams, K. P., Ragan, D. K., Binkley, M. M., Eldeniz, C., Chen, Y., Hulbert, M. L., McKinstry, R. C., Shimony, J. S., Vo, K. D., Doctor, A., An, H., Ford, A. L., & Lee, J.-M.
- Affiliations
- Washington University in St. Louis (US)
- Corresponding author
- Fields, Melanie E.
- Guilliams, Kristin P.
- Ford, Andria L.
- Lee, Jin-Moo
- ORCID
- Venue
- Neurology
- Published
- 2018-03-27
- Volume
- 90
- Issue
- 13
- Pages
- e1134-e1142
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- PMC
- PMC5880632
- OpenAlex
- W2793607856
- Cited by
- 113
- References
- 41
- Citations by year
- 2026: 12 · 2025: 9 · 2024: 11 · 2023: 12 · 2022: 21 · 2021: 15 · 2020: 13 · 2019: 14 · 2018: 5
- FWCI
- 6.66
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neurology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (UL1TR000448, UL1TR002345)
- National Heart, Lung, and Blood Institute (R01HL129241, K12HL087107, K23HL136904)
- National Institute of General Medical Sciences (R01GM113838)
- National Institute of Neurological Disorders and Stroke (K23NS099472, R01NS085419, R01NS082561, P30NS098577)
- National Center for Advancing Translational Sciences
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (U54HD087011)
- Topics
- Health Sciences › Medicine › Genetics (clinical) › Hemoglobinopathies and Related Disorders
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
- Keywords
- sickle cell disease, stroke risk, border zone, silent cerebral infarction, deep white matter, pediatric stroke, anemic hypoxia
- MeSH terms
- Adolescent, Anemia, Sickle Cell, Brain, Cerebrovascular Circulation, Child, Child, Preschool, Female, Humans, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Male, Oxygen, Oxygen Consumption, Cohort Studies, Stroke, Young Adult
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