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Cited by 242Parkinson's Disease Mechanisms and TreatmentsDementia and Cognitive Impairment ResearchNuclear Receptors and Signaling

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Association between diabetes and subsequent Parkinson disease: A record-linkage cohort study

De Pablo-Fernandez, Eduardo, Goldacre, Raph, Pakpoor, Julia, Noyce, Alastair J., Warner, Thomas T.·2018·Neurology
DOI 10.1212/wnl.0000000000005771
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Abstract

Objective To investigate the association between type 2 diabetes mellitus (T2DM) and subsequent Parkinson disease (PD). Methods Linked English national Hospital Episode Statistics and mortality data (1999–2011) were used to conduct a retrospective cohort study. A cohort of individuals admitted for hospital care with a coded diagnosis of T2DM was constructed, and compared to a reference cohort. Subsequent PD risk was estimated using Cox regression models. Individuals with a coded diagnosis of cerebrovascular disease, vascular parkinsonism, drug-induced parkinsonism, and normal pressure hydrocephalus were excluded from the analysis. Results A total of 2,017,115 individuals entered the T2DM cohort and 6,173,208 entered the reference cohort. There were significantly elevated rates of PD following T2DM (hazard ratio [HR] 1.32, 95% confidence interval [CI] 1.29–1.35; p < 0.001). The relative increase was greater in those with complicated T2DM (HR 1.49, 95% CI 1.42–1.56) and when comparing younger individuals (HR 3.81, 95% CI 2.84–5.11 in age group 25–44 years). Conclusions We report an increased rate of subsequent PD following T2DM in this large cohort study. These findings may reflect shared genetic predisposition and/or disrupted shared pathogenic pathways with potential clinical and therapeutic implications.

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Research works printed but not linked: 1

  1. National Institute for Health and Care Excellence. Parkinson's Disease in Adults. NICE Guideline NG71 [online]. Available at: nice.org.uk/guidance/NG71. Accessed August 1, 2017.

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Metadata

Authors
De Pablo-Fernandez, E., Goldacre, R., Pakpoor, J., Noyce, A. J., & Warner, T. T.
Affiliations
  • From the Reta Lila Weston Institute of Neurological Studies, Department of Molecular Neurosciences (E.D.P.-F., A.J.N., T.T.W.), and Queen Square Brain Bank for Neurological Disorders (E.D.P.-F., T.T.W.), UCL Institute of Neurology, London; Unit of Health-Care Epidemiology (R.G., J.P.), Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Population Health, University of Oxford; and Preventive Neurology Unit (A.J.N.), Wolfson Institute of Preventive...
  • Queen Mary University of London (GB)
ORCID
Venue
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2018-07-10
Volume
91
Issue
2
Pages
e139-e142
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
DOI
10.1212/wnl.0000000000005771
OpenAlex
W2807806732
Cited by
242
References
9
Citations by year
2026: 23 · 2025: 21 · 2024: 36 · 2023: 28 · 2022: 29 · 2021: 35 · 2020: 34 · 2019: 26 · 2018: 9
FWCI
17.62
Type
journal article
Language
en
Open access
closed
Locations
  • Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Funders
  • Prothena
  • Barts Charity (MGU0364)
  • National Institute for Health and Care Research (RNC/035/02)
  • Parkinson's UK
  • Brain Research Trust
  • University College London
  • University of Oxford
  • Britannia Pharmaceuticals
  • Medical Research Council (MR/L023784/2, MR/L023784/1)
  • NIHR Oxford Biomedical Research Centre
Topics
  • Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
Keywords
type 2 diabetes, Parkinson's disease, risk factors, complicated diabetes, young adults, pathogenic pathways
MeSH terms
Adult, Age Factors, Aged, Diabetes Mellitus, Type 2, England, Female, Humans, Male, Middle Aged, Parkinson Disease, Retrospective Studies, Risk Factors, Comorbidity, Case-Control Studies

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