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Cited by 253Parkinson's Disease Mechanisms and TreatmentsDeep Brain Stimulation and Movement DisordersNeurotransmitter Receptor Influence on Behavior

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Longitudinal analysis of impulse control disorders in Parkinson disease

Open access
Corvol, Jean-Christophe, Artaud, Fanny, Cormier-Dequaire, Florence, Rascol, Olivier, Durif, Franck, Derkinderen, Pascal, Marques, Ana-Raquel, Bourdain, Frédéric, Brandel, Jean-Philippe, Pico, Fernando, Lacomblez, Lucette, Bonnet, Cecilia, Brefel-Courbon, Christine, Ory-Magne, Fabienne, Grabli, David, Klebe, Stephan, Mangone, Graziella, You, Hana, Mesnage, Valérie, Lee, Pei-Chen, Brice, Alexis, Vidailhet, Marie, Elbaz, Alexis, For the DIGPD Study Group, DIGPD Study Group, Corvol, Jean-Christophe, Elbaz, Alexis, Vidailhet, Marie, Brice, Alexis, Elbaz, Alexis, Artaud, Fanny, Bourdain, Frédéric, Brandel, Jean-Philippe, Corvol, Jean-Christophe, Derkinderen, Pascal, Durif, Franck, Levy, Richard, Pico, Fernando, Rascol, Olivier, Bonnet, Anne-Marie, Bonnet, Cecilia, Brefel-Courbon, Christine, Cormier-Dequaire, Florence, Degos, Bertrand, Debilly, Bérangère, Elbaz, Alexis, Galitsky, Monique, Grabli, David, Hartmann, Andreas, Klebe, Stephan, Kraemmer, Julia, Lacomblez, Lucette, Leder, Sara, Mangone, Graziella, Mariani, Louise-Laure, Marques, Ana-Raquel, Mesnage, Valérie, Muellner, Julia, Ory-Magne, Fabienne, Planté-Bordeneuve, Violaine, Roze, Emmanuel, Tir, Melissa, Vidailhet, Marie, You, Hana, Benchetrit, Eve, Socha, Julie, Pineau, Fanny, Vidal, Tiphaine, Pomies, Elsa, Bayet, Virginie, Brice, Alexis, Lesage, Suzanne, Tahiri, Khadija, Bertrand, Hélène, Mangone, Graziella, Mallet, Alain, Villeret, Coralie, Mazmanian, Merry, Manseur, Hakima, Hajji, Mostafa, Le Toullec, Benjamin, Brochard, Vanessa, Roy, Monica, Rieu, Isabelle, Bernard, Stéphane, Faurie-Grepon, Antoine·2018·Neurology
DOI 10.1212/wnl.0000000000005816PMC PMC6059034
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Abstract

OBJECTIVE: To investigate the longitudinal dose-effect relationship between dopamine replacement therapy and impulse control disorders (ICDs) in Parkinson disease (PD). METHODS: We used data from a multicenter longitudinal cohort of consecutive patients with PD with ≤5 years' disease duration at baseline followed up annually up to 5 years. ICDs were evaluated during face-to-face semistructured interviews with movement disorder specialists. Generalized estimating equations and Poisson models with robust variance were used to study the association between several time-dependent definitions of dopamine agonist (DA) use, taking dose and duration of treatment into account, and ICDs at each visit. Other antiparkinsonian drugs were also examined. RESULTS: Among 411 patients (40.6% women, mean age 62.3 years, average follow-up 3.3 years, SD 1.7 years), 356 (86.6%) took a DA at least once since disease onset. In 306 patients without ICDs at baseline, the 5-year cumulative incidence of ICDs was 46.1% (95% confidence interval [CI] 37.4-55.7, DA ever users 51.5% [95% CI 41.8-62.1], DA never users 12.4% [95% CI 4.8-30.0]). ICD prevalence increased from 19.7% at baseline to 32.8% after 5 years. ICDs were associated with ever DA use (prevalence ratio 4.23, 95% CI 1.78-10.09). Lifetime average daily dose and duration of treatment were independently associated with ICDs with significant dose-effect relationships. Similar analyses for levodopa were not in favor of a strong association. ICDs progressively resolved after DA discontinuation. CONCLUSION: In this longitudinal study of patients with PD characterized by a high prevalence of DA treatment, the 5-year cumulative incidence of ICDs was ≈46%. ICDs were strongly associated with DA use with a dose-effect relationship; both increasing duration and dose were associated with ICDs. ICDs progressively resolved after DA discontinuation. CLINICALTRIALSGOV IDENTIFIER: NCT01564992.

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Authors
Corvol, J.-C., Artaud, F., Cormier-Dequaire, F., Rascol, O., Durif, F., Derkinderen, P., Marques, A.-R., Bourdain, F., Brandel, J.-P., Pico, F., Lacomblez, L., Bonnet, C., Brefel-Courbon, C., Ory-Magne, F., Grabli, D., Klebe, S., Mangone, G., You, H., Mesnage, V., Lee, P.-C., Brice, A., Vidailhet, M., Elbaz, A., For the DIGPD Study Group, DIGPD Study Group, Corvol, J.-C., Elbaz, A., Vidailhet, M., Brice, A., Elbaz, A., Artaud, F., Bourdain, F., Brandel, J.-P., Corvol, J.-C., Derkinderen, P., Durif, F., Levy, R., Pico, F., Rascol, O., Bonnet, A.-M., Bonnet, C., Brefel-Courbon, C., Cormier-Dequaire, F., Degos, B., Debilly, B., Elbaz, A., Galitsky, M., Grabli, D., Hartmann, A., Klebe, S., Kraemmer, J., Lacomblez, L., Leder, S., Mangone, G., Mariani, L.-L., Marques, A.-R., Mesnage, V., Muellner, J., Ory-Magne, F., Planté-Bordeneuve, V., Roze, E., Tir, M., Vidailhet, M., You, H., Benchetrit, E., Socha, J., Pineau, F., Vidal, T., Pomies, E., Bayet, V., Brice, A., Lesage, S., Tahiri, K., Bertrand, H., Mangone, G., Mallet, A., Villeret, C., Mazmanian, M., Manseur, H., Hajji, M., Le Toullec, B., Brochard, V., Roy, M., Rieu, I., Bernard, S., & Faurie-Grepon, A.
Affiliations
  • Inserm (FR)
  • Pitié-Salpêtrière Hospital (FR)
  • Centre d’Investigation Clinique 1436 (FR)
  • Institut du Cerveau (FR)
  • Centre de recherche en Epidémiologie et Santé des Populations (FR)
  • Physiopathologie des Comportements (FR)
ORCID
Venue
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2018-07-17
Volume
91
Issue
3
Pages
e189-e201
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
DOI
10.1212/wnl.0000000000005816
PMC
PMC6059034
OpenAlex
W2808883353
Cited by
253
References
31
Citations by year
2026: 20 · 2025: 27 · 2024: 33 · 2023: 23 · 2022: 25 · 2021: 31 · 2020: 41 · 2019: 42 · 2018: 11
FWCI
21.18
Type
journal article
Language
en
Open access
Locations
  • Neurology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Funders
  • Agence Nationale de la Recherche (ANR-10-IAHU-0006)
  • Assistance Publique - Hôpitaux de Paris
  • Assistance publique-Hôpitaux de Paris
Topics
  • Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
impulse control disorders, Parkinson's disease, dopamine agonists, dopamine replacement therapy, dose-response relationship, levodopa, antiparkinsonian drugs, cumulative incidence, longitudinal cohort
MeSH terms
Aged, Antiparkinson Agents, Female, Follow-Up Studies, Humans, Disruptive, Impulse Control, and Conduct Disorders, Longitudinal Studies, Male, Middle Aged, Parkinson Disease, Cohort Studies, Dopamine Agonists

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