Medication-Related Impulse Control and Repetitive Behaviors in Parkinson Disease
Abstract
A range of behaviors presumed to be related to aberrant or excessive dopaminergic medications are being increasingly recognized in Parkinson disease. These behaviors are linked by their incentive- or reward-based and repetitive natures and include pathological gambling, hypersexuality, compulsive shopping, compulsive eating, hobbyism, and compulsive medication use. Such behaviors can have potentially devastating psychosocial consequences and are often hidden. Whether these behaviors are simply related to dopaminergic medications interacting with an underlying individual vulnerability or whether the primary pathological features of Parkinson disease play a role is not known. We reviewed the literature on these behaviors in Parkinson disease, including definitions, epidemiological and potential pathophysiological features, and management. The study of these behaviors allows not only improved clinical management but also greater insight into a biologically mediated complex behavioral model.
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Administering specific dopamine agonists can activate previously non-existent behaviors such as compulsive gambling, compulsive eating, hypersexuality, and compulsive shopping.
“Thus, administering specific dopamine agonists can activate previously non-existent behaviors, such as compulsive gambling, compulsive eating, hypersexuality, and compulsive shopping (18–21).”
From Cell-phone addiction: a review (2016) · cites this paper as [18]
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- Authors
- Voon, V., & Fox, S. H.
- Affiliations
- National Institutes of Health (US)
- Venue
- Archives of Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 2007-08-01
- Volume
- 64
- Issue
- 8
- Pages
- 1089
- ISSN
- 0003-9942 (ISSN-L)
- OpenAlex
- W2104979561
- Cited by
- 397
- References
- 34
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 11 · 2023: 8 · 2022: 13 · 2021: 11 · 2020: 19 · 2019: 26 · 2018: 18 · 2017: 23 · 2016: 24 · 2015: 22 · 2014: 30 · 2013: 26 · 2012: 28
- FWCI
- 18.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Keywords
- Parkinson's disease, impulse control disorders, repetitive behavior, dopaminergic therapy, gambling addiction, hypersexuality, compulsive buying, compulsive eating, individual susceptibility, pathophysiology
- MeSH terms
- Antiparkinson Agents, Mental Disorders, Disease Susceptibility, Humans, Disruptive, Impulse Control, and Conduct Disorders, Terminology as Topic, Parkinson Disease, Dopamine Agents, Prevalence
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