Cited by 291Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsCancer-related cognitive impairment studies

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Influence of tau PET, amyloid PET, and hippocampal volume on cognition in Alzheimer disease

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Aschenbrenner, Andrew J., Gordon, Brian A., Benzinger, Tammie L.S., Morris, John C., Hassenstab, Jason J.·2018·Neurology

DOI 10.1212/wnl.0000000000006075PMC PMC6133625

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Abstract

OBJECTIVE: To examine the independent and interactive influences of neuroimaging biomarkers on retrospective cognitive decline. METHODS: F-AV-45) amyloid PET scan, and a structural MRI scan were recruited from the Knight Alzheimer Disease Research Center at Washington University in St. Louis. Cognition was assessed with standard measures reflecting episodic memory, executive functioning, semantic fluency, and processing speed. RESULTS: Results from retrospective longitudinal analyses showed that each biomarker had a univariate association with the global cognitive composite; however, when each marker was analyzed in a single statistical model, only tau was a significant predictor of global cognitive decline. There was an interaction between tau and amyloid such that tau-related cognitive decline was worse in individuals with high amyloid. There was also an interaction with hippocampal volume indicating that individuals with high levels of all 3 pathologies exhibited the greatest declines in cognition. Additional analyses within each cognitive domain indicated that tau had the largest negative influence on tests of episodic memory and executive functioning. CONCLUSIONS: Together, these results suggest that increasing levels of tau most consistently relate to declines in cognition preceding biomarker collection. These findings support models of Alzheimer disease (AD) staging that suggest that elevated β-amyloid alone may be insufficient to produce cognitive change in individuals at risk for AD and support the use of multiple biomarkers to stage AD progression.

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Authors: Aschenbrenner, A. J., Gordon, B. A., Benzinger, T. L. S., Morris, J. C., & Hassenstab, J. J.
Affiliations: Washington University in St. Louis (US)
ORCID: Aschenbrenner, Andrew J.
Gordon, Brian A.
Benzinger, Tammie L.S.
Morris, John C.
Hassenstab, Jason J.
Venue: Neurology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2018-08-28
Volume: 91
Issue: 9
Pages: e859-e866
ISSN: 0028-3878 (ISSN-L)
1526-632X
DOI: 10.1212/wnl.0000000000006075
PMC: PMC6133625
OpenAlex: W2887375324
Cited by: 290
References: 19
Citations by year: 2026: 25 · 2025: 45 · 2024: 27 · 2023: 31 · 2022: 48 · 2021: 46 · 2020: 33 · 2019: 29 · 2018: 6
FWCI: 22.43
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Neurology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (P50AG005681, P01AG003991, U01AG032438, P01AG026276, K01AG053474)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
Keywords: Alzheimer's disease, tau PET, amyloid PET, hippocampal volume, cognitive decline, neuroimaging biomarkers, episodic memory, executive function, processing speed, semantic fluency
MeSH terms: Aged, Alzheimer Disease, Amyloid, Cognition Disorders, Female, Hippocampus, Humans, Male, Middle Aged, Neuropsychological Tests, Psychiatric Status Rating Scales, Cohort Studies, tau Proteins, Positron-Emission Tomography

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Influence of tau PET, amyloid PET, and hippocampal volume on cognition in Alzheimer disease

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