The DOI matches its Crossref record, with a small difference in title or year; 7 of the 7 references it cites were found in a registry or an index.
Blood pressure and dementia: What the SPRINT-MIND trial adds and what we still need to know
Open accessAbstract
High blood pressure (BP) has been associated with an increased risk of cerebrovascular disease, stroke, and Alzheimer disease pathology. Epidemiologic studies are consistent in showing that high BP, particularly in midlife, is a risk factor for the development of dementia in late life. However, supporting randomized evidence of the inference that BP-lowering therapy can prevent dementia has been slow in coming over the last 30 years. The most recent randomized trial, the Systolic Blood Pressure Intervention Trial—Memory and Cognition in Decreased Hypertension (SPRINT-MIND), therefore, makes a pivotal contribution to the field, reemphasizing broader public health benefits of BP lowering and directing future research.1
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“The first included randomised controlled trials (RCTs) of any drug to lower blood pressure and reported a reduction in risk of around 10% at marginal significance (RR 0·9, 95% CI 0·9–1·0).”
From Dementia prevention, intervention, and care: 2020 report of the Lancet Commission (2020) · cites this paper as [81]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“Four meta-analyses of blood pressure medications to lower high blood pressure with six studies overlap have provided combined estimates of effects. All meta-analyses suggest reduced dementia in those in the interventions arms for outcomes of any dementia as well as clinically diagnosed Alzheimer's disease.”
From Dementia prevention, intervention, and care: 2020 report of the Lancet Commission (2020) · cites this paper as [81]
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“Meta-regression showed risk lowered more if the achieved systolic pressure differential was larger between the intervention and control group.”
From Dementia prevention, intervention, and care: 2020 report of the Lancet Commission (2020) · cites this paper as [81]
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Cites
The Study on Cognition and Prognosis in the Elderly (SCOPE)
Lithell, H., Hansson, L., Skoog, I. G., Elmfeldt, D., Albert Hofman, D., Olofsson, B., Trenkwalder, P., & Zanchetti, A. (2003) · Journal of Hypertension · doi:10.1097/00004872-200305000-00011 · Cited by 1,419
Williamson (2019) · doi:10.1001/jama.2018.21442 · Cited by 1,246
(2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.9.1069 · Cited by 988
Peters, R., Beckett, N., Forette, F., Tuomilehto, J., Clarke, R., Ritchie, C., Waldman, A., Walton, I., Poulter, R., Ma, S., et al. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70143-1 · Cited by 770
Self-citationDiener, H.-C., Sacco, R. L., Yusuf, S., Cotton, D., Ôunpuu, S., Lawton, W. A., Palesch, Y., Martin, R. H., Albers, G. W., Bath, P., et al. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70198-4 · Cited by 359
Ninomiya, T., Zoungas, S., Neal, B. C., Woodward, M., Patel, A. A., Perkovic, V., Cass, A., Cooper, M. E., Grobbee, D. E., Hamet, P., et al. (2010) · Journal of Hypertension · doi:10.1097/hjh.0b013e328338a89c · Cited by 57
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Dementia prevention, intervention, and care: 2020 report of the Lancet Commission
Livingston, G., Huntley, J., Sommerlad, A., Ames, D., Ballard, C., Banerjee, S., Brayne, C., Burns, A., Cohen-Mansfield, J., Cooper, C., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30367-6 · Cited by 10,430
RetractedHughes, D., Judge, C., Murphy, R., Loughlin, E., Costello, M., Whiteley, W., Bosch, J., O’Donnell, M. J., & Canavan, M. (2020) · JAMA · doi:10.1001/jama.2020.4249 · Cited by 472
Prevention of dementia in an ageing world: Evidence and biological rationale
Grande, G., Qiu, C., & Fratiglioni, L. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101045 · Cited by 229
Hypertension and Cognitive Impairment: A Review of Mechanisms and Key Concepts
Canavan, M. D., & O'Donnell, M. J. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.821135 · Cited by 180
Chinese Guidelines for the Prevention and Treatment of Hypertension (2024 revision)
Wang, J. (2025) · 老年心脏病学杂志：英文版 · doi:10.26599/1671-5411.2025.01.008 · Cited by 170
Metadata
- Authors
- Peters, R., Warwick, J., Anstey, K. J., & Anderson, C. S.
- Affiliations
- The George Institute for Global Health (GB)
- Venue
- Neurology
- Published
- 2019-05-21
- Volume
- 92
- Issue
- 21
- Pages
- 1017-1018
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2940519437
- Cited by
- 68
- References
- 7
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 7 · 2023: 8 · 2022: 14 · 2021: 13 · 2020: 13 · 2019: 3
- FWCI
- 8.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- UNSWorks (UNSW Sydney) (submittedVersion, cc-by-nc-nd)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Warwick Research Archive Portal (University of Warwick) (submittedVersion)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, public-domain)
- DRYAD (public-domain)
- Funders
- Amgen
- National Institute for Health and Care Research (PDF-2012-05-197)
- Dementia Centre for Research Collaboration
- Medical Research Council
- National Health and Medical Research Council
- National Institute for Dementia Research
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- blood pressure, hypertension, dementia, Alzheimer's disease, cerebrovascular disease, stroke, midlife blood pressure, blood pressure-lowering therapy, dementia prevention, cognitive decline
- MeSH terms
- Antihypertensive Agents, Blood Pressure, Blood Pressure Determination, Dementia, Humans
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