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Cited by 226Gastrointestinal motility and disordersParkinson's Disease Mechanisms and TreatmentsProbiotics and Fermented Foods

The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.

Probiotics for Constipation in Parkinson Disease: A Randomized Placebo-Controlled Study

Tan, Ai Huey, Lim, Shen-Yang, Chong, Kah Kian, A Manap, Mohammad Addin Azhan, Hor, Jia Wei, Lim, Jia Lun, Low, Soon Chai, Chong, Chun Wie, Mahadeva, Sanjiv, Lang, Anthony E.·2021·Neurology
DOI 10.1212/wnl.0000000000010998
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Abstract

OBJECTIVE: To determine whether probiotics are effective for constipation, a common and often difficult-to-treat problem, in Parkinson disease (PD). METHODS: In this double-blind, randomized, placebo-controlled, single-center trial, 280 patients with PD were screened, and 72 eligible patients were block-randomized (1:1) to receive either multistrain probiotics capsules (n = 34) or identical-appearing placebo (n = 38), for 4 weeks. The primary endpoint was the change in the average number of spontaneous bowel movements (SBM) per week during the last 2 weeks of intervention compared with the 2-week preintervention phase, recorded by daily stool diary. Secondary outcome measures included changes in stool consistency, constipation severity score, and quality of life related to constipation. Satisfaction with intervention received was assessed. Change in levels of fecal calprotectin, a marker of intestinal inflammation, was an exploratory outcome. RESULTS: < 0.001). One patient (2.9%) in the treatment group withdrew due to a nonserious adverse event. Fecal calprotectin did not change significantly during the study. CONCLUSIONS: Multistrain probiotics treatment was effective for constipation in PD. Further studies are needed to investigate the long-term efficacy and safety of probiotics in PD, as well as their mechanisms of action. CLINICALTRIALSGOV IDENTIFIER: NCT03377322. CLASSIFICATION OF EVIDENCE: This study provides Class I evidence that, for people with PD, multistrain probiotics significantly increased the average number of SBM per week.

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Crossref · 10.1212/wnl.0000000000010998

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Research works printed but not linked: 1

  1. Health Canada Probiotics Monograph. Available at: webprod.hc-sc.gc.ca/nhpid-bdipsn/atReq.do?atid=probio&lang=eng. Accessed June 28, 2020.

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Metadata

Authors
Tan, A. H., Lim, S.-Y., Chong, K. K., A Manap, M. A. A., Hor, J. W., Lim, J. L., Low, S. C., Chong, C. W., Mahadeva, S., & Lang, A. E.
Affiliations
  • Monash University Malaysia (MY)
  • From the Division of Neurology (A.H.T., S.-Y.L., K.K.C., M.A.A.A.M., J.W.H., J.L.L., S.C.L.), Department of Medicine, and the Mah Pooi Soo &amp; Tan Chin Nam Centre for Parkinson's &amp; Related Disorders (A.H.T., S.-Y.L., K.K.C., M.A.A.A.M., J.W.H., J.L.L., S.C.L.), Faculty of Medicine, University of Malaya, Kuala Lumpur; School of Pharmacy (C.W.C.), Monash University Malaysia, Selangor; Division of Gastroenterology (S.M.), Department of Medicine, Faculty of Medicine, University of Malaya, Kuala...
ORCID
Venue
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2021-02-02
Volume
96
Issue
5
Pages
e772-e782
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
DOI
10.1212/wnl.0000000000010998
OpenAlex
W3092261610
Cited by
226
References
52
Citations by year
2026: 28 · 2025: 44 · 2024: 48 · 2023: 43 · 2022: 36 · 2021: 24
FWCI
23.01
Type
journal article
Language
en
Open access
closed
Locations
  • Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords
probiotics, Parkinson's disease, constipation, multi-strain probiotics, spontaneous bowel movements, stool consistency, fecal calprotectin, intestinal inflammation, quality of life
MeSH terms
Aged, Constipation, Double-Blind Method, Feces, Female, Humans, Male, Middle Aged, Parkinson Disease, Quality of Life, Patient Satisfaction, Probiotics, Leukocyte L1 Antigen Complex

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