The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Aducanumab, Amyloid Lowering, and Slowing of Alzheimer Disease
Open accessAbstract
Aducanumab (Aduhelm) was recently approved by the US Food and Drug Administration (FDA) for the treatment of Alzheimer disease (AD). The approval of aducanumab is controversial. We address why we support this decision and welcome the availability of aducanumab as an important therapy for patients with early AD.
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“The FDA has controversially granted accelerated approval to aducanumab and has opined that the reduction of amyloid is reasonably likely to predict clinical benefit 7,9,[98][99][100][101][102][103][104][105][106][107] .”
From The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics (2022) · cites this paper as [105]
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Donanemab in Early Alzheimer’s Disease
Mintun, M. A., Lo, A. C., Duggan Evans, C., Wessels, A. M., Ardayfio, P. A., Andersen, S. W., Shcherbinin, S., Sparks, J., Sims, J. R., Brys, M., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2100708 · Cited by 1,728
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- Leber P. Guidelines for the clinical evaluation of antidementia drugs. Food and Drug Administration; 1990.
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Sorted by citations
The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics
Karran, E., & De Strooper, B. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00391-w · Cited by 742
Neuropathology of Alzheimer's Disease
Trejo‐Lopez, J. A., Yachnis, A. T., & Prokop, S. (2021) · Neurotherapeutics · doi:10.1007/s13311-021-01146-y · Cited by 419
Blood-brain barrier leakage in Alzheimer’s disease: From discovery to clinical relevance
Nehra, G., Bauer, B., & Hartz, A. M. S. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108119 · Cited by 127
Anti-Amyloid Therapies for Alzheimer’s Disease and the Amyloid Cascade Hypothesis
Fedele, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914499 · Cited by 102
Lacorte, E., Ancidoni, A., Zaccaria, V., Remoli, G., Tariciotti, L., Bellomo, G., Sciancalepore, F., Corbo, M., Lombardo, F. L., Bacigalupo, I., et al. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220046 · Cited by 104
Metadata
- Authors
- Salloway, S., & Cummings, J.
- Affiliations
- University of Nevada, Las Vegas (US)
- Venue
- Neurology
- Published
- 2021-09-14
- Volume
- 97
- Issue
- 11
- Pages
- 543-544
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- PMC
- PMC8456361
- OpenAlex
- W3178304290
- Cited by
- 34
- References
- 1
- Citations by year
- 2025: 2 · 2024: 5 · 2023: 4 · 2022: 16 · 2021: 7
- FWCI
- 5.18
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neurology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Eli Lilly and Company (P20GM109025)
- Biogen (P20GM109025)
- Sunovion
- Eisai (P20GM109025)
- Novo Nordisk
- Grifols
- Genentech (P20GM109025)
- National Institute on Aging (R01AG053798, P20AG068053, R35AG71476, P30AG072980)
- National Institute of General Medical Sciences (NIA R35AG71476, P20GM109025)
- National Institute of Neurological Disorders and Stroke (U01NS093334)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Pharmacology (medical) › Cholinesterase and Neurodegenerative Diseases
- Keywords
- aducanumab, Alzheimer's disease, anti-amyloid therapy, FDA drug approval, early Alzheimer's disease, anti-amyloid monoclonal antibodies
- MeSH terms
- Alzheimer Disease, Amyloid, Humans, Antibodies, Monoclonal, Humanized
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