The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Plasma P-tau181 and P-tau217 in Patients With Traumatic Encephalopathy Syndrome With and Without Evidence of Alzheimer Disease Pathology
Open accessAbstract
BACKGROUND AND OBJECTIVES: Traumatic encephalopathy syndrome (TES) has overlapping clinical symptoms with Alzheimer disease (AD). AD pathology commonly co-occurs with chronic traumatic encephalopathy (CTE) pathology. There are currently no validated CTE biomarkers. AD-specific biomarkers such as plasma P-tau181 and P-tau217 may help to identify patients with TES who have AD pathology. METHODS: We measured plasma P-tau181 and P-tau217 (Meso Scale Discovery electrochemiluminescence) in patients with TES, mild cognitive impairment/dementia with biomarker-confirmed AD ("AD"), and healthy controls ("HC"). Patients underwent amyloid-beta (Aβ)-PET and a subset underwent tau-PET using [18F]Flortaucipir. We compared plasma P-tau levels controlling for age and sex and also performed AUC analyses to evaluate the accuracy of group differentiation. In patients with TES, we evaluated associations between plasma P-tau, years of repetitive head impact exposure, and tau-PET. Four TES patients with autopsy-confirmed CTE were described qualitatively. RESULTS: = 0.13). Patients with AD had higher tau-PET tracer uptake than Aβ(+) TES and were well differentiated using P-tau181 (AUC = 0.81 [0.68-0.94]) and P-tau217 (AUC = 0.86 [0.73-0.98]). Plasma P-tau correlated with the tau-PET signal in Aβ(+) TES but not in Aβ(-) TES, and there was no association between plasma P-tau and years of repetitive head impact exposure. TES patients with severe CTE and no AD at autopsy had low P-tau181 and P-tau217 levels. DISCUSSION: Measuring P-tau181 and P-tau217 in plasma may be a feasible and scalable fluid biomarker for identifying AD pathology in TES. Low plasma P-tau levels may be used to increase clinical suspicion of CTE over AD as a primary pathology in TES. Currently, there is no support for P-tau181 or P-tau217 as in vivo biomarkers of CTE tau. Larger studies of patients with pathologically confirmed CTE are needed. CLASSIFICATION OF EVIDENCE: This study provides Class III evidence that (1) among patients with TES and abnormal Aβ-PET scans, elevated plasma P-tau can differentiate between affected individuals and HCs; (2) low plasma P-tau may help identify patients with TES who do not have Alzheimer; and (3) plasma P-tau181 and P-tau217 are not useful biomarkers of patients with TES who do not have AD.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“It appears to be more specific for AD pathology, at least compared to frontotemporal dementia and chronic traumatic encephalopathy (85, 91, 92), but it is increased in prion disease (83).”
From All the Tau We Cannot See (2023) · cites this paper as [91]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Dementia prevention, intervention, and care: 2020 report of the Lancet Commission
Livingston, G., Huntley, J., Sommerlad, A., Ames, D., Ballard, C., Banerjee, S., Brayne, C., Burns, A., Cohen-Mansfield, J., Cooper, C., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30367-6 · Cited by 10,430 · cited 15×
“We then evaluated how well plasma P-tau181 and P-tau217 discriminated between participants with TES (stratified by Aβ status) and AD.”
BackgroundInfluentialRetractedMcKhann, G. M., Knopman, D. S., Chertkow, H., Hyman, B. T., Jack, C. R., Kawas, C. H., Klunk, W. E., Koroshetz, W. J., Manly, J. J., Mayeux, R., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.005 · Cited by 18,657
Albert, M. S., DeKosky, S. T., Dickson, D., Dubois, B., Feldman, H. H., Fox, N. C., Gamst, A., Holtzman, D. M., Jagust, W. J., Petersen, R. C., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.008 · Cited by 10,152 · cited 2×
“Participants with AD met clinical research criteria for probable AD dementia10 or MCI.18 To maximize specificity of underlying AD pathology, all participants with AD had both Aβ-PET and tau-PET imaging consistent with AD.”
MethodCohen, J. (1992) · Current Directions in Psychological Science · doi:10.1111/1467-8721.ep10768783 · Cited by 5,870
Classification of primary progressive aphasia and its variants
Gorno-Tempini, M. L., Hillis, A. E., Weintraub, S., Kertesz, A., Mendez, M., Cappa, S. F., Ogar, J. M., Rohrer, J. D., Black, S., Boeve, B. F., et al. (2011) · Neurology · doi:10.1212/wnl.0b013e31821103e6 · Cited by 5,141
Self-citationHyman, B. T., Phelps, C. H., Beach, T. G., Bigio, E. H., Cairns, N. J., Carrillo, M. C., Dickson, D. W., Duyckaerts, C., Frosch, M. P., Masliah, E., et al. (2012) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.10.007 · Cited by 3,092
The spectrum of disease in chronic traumatic encephalopathy
McKee, A. C., Stein, T. D., Nowinski, C. J., Stern, R. A., Daneshvar, D. H., Alvarez, V. E., Lee, H.-S., Hall, G., Wojtowicz, S. M., Baugh, C. M., et al. (2013) · Brain · doi:10.1093/brain/aws307 · Cited by 2,098
Qualitative Assessment of Verbal Fluency Performance in Frontotemporal Dementia
van den Berg, E., Jiskoot, L. C., Grosveld, M. J. H., Swieten, J. C. V., & Papma, J. M. (2017) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000477538 · Cited by 2,065
Morris, J. C. (1997) · International Psychogeriatrics · doi:10.1017/s1041610297004870 · Cited by 1,641
Palmqvist, S., Janelidze, S., Quiroz, Y. T., Zetterberg, H., Lopera, F., Stomrud, E., Su, Y., Chen, Y., Serrano, G. E., Leuzy, A., et al. (2020) · JAMA · doi:10.1001/jama.2020.12134 · Cited by 1,603
Cited by
Sorted by citations
Prevalence of Alzheimer’s disease pathology in the community
Aarsland, D., Sunde, A. L., Tovar, D., Leuzy, A., Fladby, T., Zetterberg, H., Blennow, K., Tan, K., Santis, G. D., Yakoub, Y., et al. (2025) · Nature · doi:10.1038/s41586-025-09841-y · Cited by 75
Saloner, R., VandeVrede, L. A., Asken, B. M., Paolillo, E. W., Gontrum, E. Q., Wolf, A. A., Lario‐Lago, A., Milà‐Alomà, M., Triana‐Baltzer, G., Kolb, H. C., et al. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.13454 · Cited by 49
Self-citationHyman, B. (2023) · Annual Review of Medicine · doi:10.1146/annurev-med-042921-023749 · Cited by 39
Fluid biomarkers of chronic traumatic brain injury
Friberg, S., Lindblad, C., Zeiler, F. A., Zetterberg, H., Granberg, T., Svenningsson, P., Piehl, F., & Thelin, E. P. (2024) · Nature Reviews Neurology · doi:10.1038/s41582-024-01024-z · Cited by 36
Blood biomarkers and neurodegeneration in individuals exposed to repetitive head impacts
Bernick, C. B., Shan, G., Ritter, A. R., Ashton, N. J., Blennow, K., Lantero‐Rodriguez, J., Snellman, A., & Zetterberg, H. (2023) · Alzheimer s Research & Therapy · doi:10.1186/s13195-023-01310-w · Cited by 23
Miner, A. E., Groh, J. R., Tripodis, Y., Adler, C. H., Balcer, L. J., Bernick, C. B., Zetterberg, H., Blennow, K., Peskind, E. R., Ashton, N. J., et al. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14231 · Cited by 20
Lember, L.-M., Ntikas, M., Mondello, S., Wilson, L., Virgilio, T. G. D., Hunter, A. M., Kobeissy, F. H., Mechref, Y. S., Donaldson, D. I., & Ietswaart, M. (2024) · Sports Medicine - Open · doi:10.1186/s40798-023-00665-6 · Cited by 23
Asken, B. M., Tanner, J. A., Gaynor, L. S., VandeVrede, L. A., Mantyh, W. G., Casaletto, K. B., Staffaroni, A. M., Fonseca, C. S., Shankar, R. P., Grant, H. E., et al. (2023) · Alzheimer s Research & Therapy · doi:10.1186/s13195-023-01275-w · Cited by 24
Self-citationvan Amerongen, S., Kamps, S., Kaijser, K. K. M., Pijnenburg, Y. A. L., Scheltens, P., Teunissen, C. E., Barkhof, F., Ossenkoppele, R., Rozemüller, A. J. M., Stern, R. A., et al. (2023) · Acta Neuropathologica Communications · doi:10.1186/s40478-023-01572-3 · Cited by 21
Halicki, M. J., Hind, K., & Chazot, P. L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241612556 · Cited by 20
Corrigan, J. D., Alosco, M. L., van der Naalt, J., Adams, R. S., Asken, B. M., Hinds, S., Lequerica, A. H., Newcombe, V., Tenovuo, O., Valera, E., et al. (2025) · Journal of Neurotrauma · doi:10.1089/neu.2024.0590 · Cited by 15
Self-citationInvestigating the use of plasma pTau181 in retired contact sports athletes
Vasilevskaya, A., Taghdiri, F., Multani, N., Ozzoude, M., Tarazi, A., Khodadadi, M., Wennberg, R. A., Rusjan, P., Houle, S., Green, R., et al. (2022) · Journal of Neurology · doi:10.1007/s00415-022-11223-7 · Cited by 14
Biomarker evidence of neurodegeneration in mid-life former rugby players
Graham, N., Zimmerman, K. A., Hain, J., Rooney, E. J., Lee, Y., Giovane, M. D., Parker, T. D., Wilson, M. G., Malhotra, P., David, M., et al. (2025) · Brain · doi:10.1093/brain/awaf152 · Cited by 12
Dhaynaut, M., Grashow, R. G., Normandin, M. D., Wu, O., Marengi, D. A., Terry, D. P., Sanchez, J. S., Weisskopf, M. G., Speizer, F. E., Taylor, H. A., et al. (2023) · Journal of Neurotrauma · doi:10.1089/neu.2022.0454 · Cited by 13
Chronic traumatic encephalopathy: State-of-the-science update and narrative review
Asken, B. M., Brett, B. L., Barr, W., Banks, S. J., Wethe, J. V., Dams-O’Connor, K., Stern, R. A., & Alosco, M. L. (2025) · The Clinical Neuropsychologist · doi:10.1080/13854046.2025.2454047 · Cited by 12
Self-citationPlasma brain-derived tau: analytical and clinical validation of the first commercial immunoassay
Nafash, M. N., Svirsky, S. E., Zeng, X., Chen, Y., Kofler, J., Cohen, A. D., Okonkwo, D. O., López, O. L., Puccio, A. M., & Karikari, T. K. (2026) · Scientific Reports · doi:10.1038/s41598-026-40271-6 · Cited by 8
Biomarkers of chronic traumatic encephalopathy: A state-of-the art review
Gerges, J. A., Chalhoub, I., Atallah, C., & Khoury, R. (2023) · Biomarkers in Neuropsychiatry · doi:10.1016/j.bionps.2023.100066 · Cited by 7
Grashow, R. G., Eagle, S. R., Terry, D. P., DiGregorio, H., Baggish, A. L., Weisskopf, M. G., Kontos, A. P., Okonkwo, D. O., & ZAFONTE, R. D. (2024) · Neurotrauma Reports · doi:10.1089/neur.2024.0008 · Cited by 7
Brett, B. L., Sullivan, M. E., Asken, B. M., Terry, D. P., Meier, T. B., & McCrea, M. (2025) · The Clinical Neuropsychologist · doi:10.1080/13854046.2024.2442427 · Cited by 7
Self-citationZhao, X., & He, Z. (2025) · Neuroscience Research · doi:10.1016/j.neures.2025.104979 · Cited by 5
Kleven, B. D. C., Chien, L., Cross, C., Labus, B., & Bernick, C. (2025) · The journal of head trauma rehabilitation · doi:10.1097/htr.0000000000001048 · Cited by 4
Plasma and MRI biomarkers capture neuronal damage in former professional boxers
Kamps, S., van Amerongen, S., Blujdea, E. R., Hoppen, M. I., Bongers, B., Schelvis, K. H., Caton, D. K., Königs, M., Teunissen, C. E., Scheltens, P., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-93066-6 · Cited by 4
18F-Flortaucipir (AV1451) imaging identifies grey matter atrophy in retired athletes
Vasilevskaya, A., Anastassiadis, C., Thapa, S., Taghdiri, F., Khodadadi, M., Multani, N., Rusjan, P., Ozzoude, M., Tarazi, A., Mushtaque, A., et al. (2024) · Journal of Neurology · doi:10.1007/s00415-024-12573-0 · Cited by 4
Retired contact sports athletes with cognitive concerns: promoting lifelong brain health
Graham, N., Giovane, M. D., Hain, J., Rooney, E. J., Zimmerman, K. A., Lee, Y., Friedland, D., Parker, T. D., Fleminger, S., Patel, M. C., et al. (2025) · Practical Neurology · doi:10.1136/pn-2025-004786 · Cited by 3
Early cerebrospinal fluid elevations of pTau-217 in severe traumatic brain injury subjects
Yadikar, H., Kobeissy, F. H., Robertson, C. S., Tsetsou, S., Williamson, J. B., Lamb, D. G., Wagner, A. K., Kibaugh, T., Kao, S.-H., Kou, Z., et al. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1632679 · Cited by 3
Zhang, S., Jiao, B., Zeng, Y., Sun, Q., Chen, X., Zhang, W., Ouyang, Z., Xiao, Q., Zhou, L., Li, Y., et al. (2026) · EBioMedicine · doi:10.1016/j.ebiom.2026.106127 · Cited by 2
Kleven, B. C., Chien, L.-C., Surwill, D. L., Alosco, M. L., Wethe, J. V., Tripodis, Y., Adler, C. H., Shenton, M. E., Pasternak, O., Katz, D. I., et al. (2026) · Alzheimer s Research & Therapy · doi:10.1186/s13195-026-02110-8 · Cited by 2
Diffusion Alterations at the Gray Matter/White Matter Boundary in Traumatic Encephalopathy Syndrome
Wiegand, T. L. T., Pankatz, L., Arciniega, H., Jung, L., Tuz‐Zahra, F., Sylvain Bouix, A., Lubeck, H., Rojczyk, P., Schuhmacher, L. S., Buring, J. E., et al. (2025) · Journal of Neurotrauma · doi:10.1177/08977151251393966 · Cited by 1
Dybing, K. M., Gao, S., Saykin, A. J., Risacher, S. L., & Initiative, A. D. N. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251401201 · Cited by 1
Prior Traumatic Brain Injury and Alzheimer Disease Blood Biomarkers
Lang, Y. R., Vrillon, A., Pasternak, S., Blazhenets, G., Soleimani‐Meigooni, D. N., Rabinovici, G. D., Weiner, M. W., Hantke, N. C., Silbert, L. C., Schwartz, D. L., et al. (2026) · JAMA Neurology · doi:10.1001/jamaneurol.2026.2042 · Cited by 1
Self-citationPlasma Phosphorylated Tau 217 in Participants at Risk for Chronic Traumatic Encephalopathy
Miner, A. E., Zetterberg, H., Blennow, K., Groh, J. R., Singh, A., Dieckhoff, K., Tripodis, Y., Adler, C. H., Balcer, L. J., Bernick, C. B., et al. (2026) · JAMA Network Open · doi:10.1001/jamanetworkopen.2026.22966 · Cited by 1
Self-citationBernick, C. B., Shan, G., Ritter, A., Ashton, N. J., Blennow, K., Lantero‐Rodriguez, J., Snellman, A., & Zetterberg, H. (2024) · Figshare · doi:10.6084/m9.figshare.26626312
van Amerongen, S., Kamps, S., Kaijser, K. K. M., Pijnenburg, Y. A. L., Scheltens, P., Teunissen, C. E., Barkhof, F., Ossenkoppele, R., Rozemüller, A. J. M., Stern, R. A., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22792784
Bernick, C. B., Shan, G., Ritter, A., Ashton, N. J., Blennow, K., Lantero‐Rodriguez, J., Snellman, A., & Zetterberg, H. (2024) · Figshare · doi:10.6084/m9.figshare.26626315
Effect of prior traumatic brain injury on Alzheimer’s disease blood biomarkers in Vietnam VeteransPreprint
Lang, Y. R., Vrillon, A., Pasternak, S., Blazhenets, G., Soleimani-Meigooni, D., Rabinovici, G. D., Weiner, M. W., Hantke, N. C., Silbert, L. C., Schwartz, D. L., et al. (2026) · medRxiv · doi:10.64898/2026.01.13.26344009
Self-citationGroh, J. R., Miner, A. E., Alshikho, M. J., Farris, C. W., Cui, A., Pettway, E. C., Labonte, J., Mosaheb, S., Tripodis, Y., Adler, C. H., et al. (2026) · Alzheimer s & Dementia · doi:10.1002/alz.71351
Self-citationMiner, A. E., Aaronson, A., Trujillo‐Rodriguez, D., Groh, J. R., & Alosco, M. L. (2026) · Seminars in Pediatric Neurology · doi:10.1016/j.spen.2026.101318
Fernandes, J. R., de Brito, M. A., Costa, K. F., Inostroza-Ríos, F., Roa-Gamboa, I. A., Almeida, N., Camargos, E. F., Díaz-de-Durana, A. L., Miarka, B., Nóbrega, O. D. T., et al. (2026) · Sports · doi:10.3390/sports14070272
Kamps, S., Habraken, E. H. J., van Amerongen, S., van Paassen, D. N., de Boer, S. C. M., Coomans, E. M., Sikkes, S. A. M., Scheltens, P., Ossenkoppele, R., & Vijverberg, E. G. B. (2026) · Alzheimer s Research & Therapy · doi:10.1186/s13195-026-02122-4
Traumatic Brain Injury and the Road to Alzheimer’s Disease
Kaveh, R., Kamari, F., Høilund‐Carlsen, P. F., Blaabjerg, M., Christensen, A. A., Poulsen, F. R., Ghaedi, S., Alavi, A. A., & Andalib, S. (2026) · Biomedicines · doi:10.3390/biomedicines14092056
Metadata
- Authors
- Asken, B. M., Tanner, J. A., VandeVrede, L., Mantyh, W. G., Casaletto, K. B., Staffaroni, A. M., La Joie, R., Iaccarino, L., Soleimani-Meigooni, D., Rojas, J. C., Gardner, R. C., Miller, B. L., Grinberg, L. T., Boxer, A. L., Kramer, J. H., & Rabinovici, G. D.
- Affiliations
- University of Minnesota (US)
- From the Memory and Aging Center (B.M.A.T.C., J.A.T., L.V., W.G.M., K.B.C., A.M.S., R.L.J., L.I., D.S.-M., J.C.R., R.C.G., B.L.M., L.T.G., A.L.B., J.H.K., G.D.R.), Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco; Department of Neurology (W.G.M.), University of Minnesota, Minneapolis; San Francisco Veterans Affairs Medical Center (R.C.G.); and Department of Radiology & Biomedical Imaging, University of California (G.D.R.), San Francisco.
- ORCID
- Venue
- Neurology
- Published
- 2022-08-09
- Volume
- 99
- Issue
- 6
- Pages
- e594-e604
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- PMC
- PMC9442622
- OpenAlex
- W4280514047
- Cited by
- 40
- References
- 51
- Citations by year
- 2026: 11 · 2025: 12 · 2024: 7 · 2023: 8 · 2022: 2
- FWCI
- 4.73
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neurology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Alzheimer's Association
- National Institutes of Health
- National Institute on Aging (K23AG059888, R01AG045611, U01AG057195, R01AG064314, R01AG048234, R21AG069252, K23AG061253, L30 AG069301, K23AG031861, RF1AG032289, K99AG065501, K24AG045333, R01AG038791, U19AG063911, P01AG019724, R01AG060477, P30AG062422, K23AG073514, R01AG032289, R01AG072475, T32AG023481)
- National Institute of Neurological Disorders and Stroke (U54NS100717, K23NS095755, U54NS092089)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
- Keywords
- traumatic encephalopathy syndrome, chronic traumatic encephalopathy, Alzheimer's disease, p-tau181, p-tau217, fluid biomarkers, tau PET, amyloid PET, differential diagnosis, mild cognitive impairment, dementia, 18F-flortaucipir, electrochemiluminescence
- MeSH terms
- Chronic Traumatic Encephalopathy, Alzheimer Disease, Dementia, Humans, Syndrome, Biomarkers, Amyloid beta-Peptides, tau Proteins, Positron-Emission Tomography
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
