The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Nonalcoholic Fatty Liver Disease and Risk of Dementia: A Population-Based Cohort Study
Open accessAbstract
BACKGROUND AND OBJECTIVES: Nonalcoholic fatty liver disease (NAFLD) and dementia share common risk factors including metabolic disorders. However, whether NAFLD is associated with dementia risk is unclear. We investigated the association between NAFLD and dementia risk as well as the role of cardiovascular complications including heart disease and stroke. METHODS: In this population-based matched cohort study, we identified all Swedish patients aged 65 years or older with NAFLD identified from the National Patient Register (NPR) between 1987 and 2016. These were matched with up to 10 reference individuals from the general population on age, sex, and municipality at the year of diagnosis. Incident dementia diagnosis was derived from the NPR or the Cause of Death Register until 2016. Adjusted hazard ratios (aHRs) and 95% CIs were estimated with Cox regression models. RESULTS: = 0.07). Comorbid NAFLD and either heart disease (aHR 1.50 95% 1.08-2.05) or stroke (aHR 2.60 95% CI 1.95-3.47) conferred a greater risk of dementia. DISCUSSION: NAFLD had a modest association with increased rates of dementia. This was stronger among patients with NAFLD diagnosed with cardiovascular comorbidities. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that nonalcoholic fatty liver disease is associated with the development of vascular and nonvascular dementia.
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“non-alcoholic fatty liver disease has been linked to an increased risk of dementia [61]”
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1 retracted
Dementia prevention, intervention, and care: 2020 report of the Lancet Commission
Livingston, G., Huntley, J., Sommerlad, A., Ames, D., Ballard, C., Banerjee, S., Brayne, C., Burns, A., Cohen-Mansfield, J., Cooper, C., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30367-6 · Cited by 10,430
RetractedExternal review and validation of the Swedish national inpatient register
Ludvigsson, J. F., Andersson, E., Ekbom, A., Feychting, M., Kim, J.-L., Reuterwall, C., Heurgren, M., & Olausson, P. O. (2011) · BMC Public Health · doi:10.1186/1471-2458-11-450 · Cited by 5,055
Global perspectives on nonalcoholic fatty liver disease and nonalcoholic steatohepatitis
Younossi, Z., Tacke, F., Arrese, M., Chander Sharma, B., Mostafa, I., Bugianesi, E., Wai‐Sun Wong, V., Yilmaz, Y., George, J., Fan, J., et al. (2019) · Hepatology · doi:10.1002/hep.30251 · Cited by 1,858 · cited 1×
“Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, affecting 25% of the global population.(1) NAFLD is associated with metabolic disorders and is commonly seen as the hepatic manifestation of the metabolic syndrome, and acquiring additional components of the metabolic syndrome, such as…”
BackgroundHagström, H., Nasr, P., Ekstedt, M., Hammar, U., Stål, P., Hultcrantz, R., & Kechagias, S. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.07.027 · Cited by 1,067
Self-citationAssociation between age at diabetes onset and subsequent risk of dementia
Barbiellini Amidei, C., Fayosse, A., Dumurgier, J., Machado-Fragua, M. D., Tabak, A. G., van Sloten, T., Kivimäki, M., Dugravot, A., Sabia, S., & Singh-Manoux, A. (2021) · JAMA · doi:10.1001/jama.2021.4001 · Cited by 355
Weinstein, G., Zelber-Sagi, S., Preis, S. R., Beiser, A. S., DeCarli, C., Speliotes, E. K., Satizabal, C. L., Vasan, R. S., & Seshadri, S. (2018) · JAMA Neurology · doi:10.1001/jamaneurol.2017.3229 · Cited by 186
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Barber, A. J., del Genio, C. L., Swain, A. B., Pizzi, E. M., Watson, S. C., Tapiavala, V. N., Zanazzi, G. J., & Gaur, A. B. (2024) · Alzheimer's Research & Therapy · doi:10.1186/s13195-024-01492-x · Cited by 41
Metadata
- Authors
- Shang, Y., Widman, L., & Hagström, H.
- Affiliations
- Karolinska University Hospital (SE)
- Corresponding author
- Shang, Ying
- Venue
- Neurology
- Published
- 2022-08-09
- Volume
- 99
- Issue
- 6
- Pages
- e574-e582
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- PMC
- PMC9442617
- OpenAlex
- W4285391459
- Cited by
- 85
- References
- 6
- Citations by year
- 2026: 21 · 2025: 20 · 2024: 22 · 2023: 18 · 2022: 4
- FWCI
- 11.62
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Neurology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Vetenskapsrådet
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- non-alcoholic fatty liver disease, dementia, cardiovascular comorbidity, heart disease, stroke, vascular dementia, older adults, metabolic disorders
- MeSH terms
- Female, Heart Diseases, Humans, Male, Risk Factors, Dementia, Vascular, Cohort Studies, Stroke, Non-alcoholic Fatty Liver Disease
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