The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Good clinical outcome after ischemic stroke with successful revascularization is time-dependent
Open accessAbstract
BACKGROUND: Trials of IV recombinant tissue plasminogen activator (rt-PA) have demonstrated that longer times from ischemic stroke symptom onset to initiation of treatment are associated with progressively lower likelihoods of clinical benefit, and likely no benefit beyond 4.5 hours. How the timing of IV rt-PA initiation relates to timing of restoration of blood flow has been unclear. An understanding of the relationship between timing of angiographic reperfusion and clinical outcome is needed to establish time parameters for intraarterial (IA) therapies. METHODS: The Interventional Management of Stroke pilot trials tested combined IV/IA therapy for moderate-to-severe ischemic strokes within 3 hours from symptom onset. To isolate the effect of time to angiographic reperfusion on clinical outcome, we analyzed only middle cerebral artery and distal internal carotid artery occlusions with successful reperfusion (Thrombolysis in Cerebral Infarction 2-3) during the interventional procedure (<7 hours). Time to angiographic reperfusion was defined as time from stroke onset to procedure termination. Good clinical outcome was defined as modified Rankin Score 0-2 at 3 months. RESULTS: Among the 54 cases, only time to angiographic reperfusion and age independently predicted good clinical outcome after angiographic reperfusion. The probability of good clinical outcome decreased as time to angiographic reperfusion increased (unadjusted p = 0.02, adjusted p = 0.01) and approached that of cases without angiographic reperfusion within 7 hours. CONCLUSIONS: We provide evidence that good clinical outcome following angiographically successful reperfusion is significantly time-dependent. At later times, angiographic reperfusion may be associated with a poor risk-benefit ratio in unselected patients.
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Cites
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Recombinant tissue plasminogen activator in acute thrombotic and embolic stroke
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Cited by
Capillary pericytes regulate cerebral blood flow in health and disease
Hall, C. N., Reynell, C., Gesslein, B., Hamilton, N. B., Mishra, A., Sutherland, B. A., O’Farrell, F. M., Buchan, A. M., Lauritzen, M., & Attwell, D. (2014) · Nature · doi:10.1038/nature13165 · Cited by 1,870
Timing of Recanalization and Functional Recovery in Acute Ischemic Stroke
Tsivgoulis, G., Saqqur, M., Sharma, V. K., Brunser, A., Eggers, J., Mikulik, R., Katsanos, A. H., Sergentanis, T. N., Vadikolias, K., Perren, F., et al. (2020) · Journal of Stroke · doi:10.5853/jos.2019.01648 · Cited by 68
Vanacker, P., Lambrou, D., Eskandari, A., Ntaios, G., Cras, P., Maeder, P., Meuli, R., & Michel, P. (2015) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2015.04.002 · Cited by 18
Mechanical thrombectomy for the treatment of acute ischemic stroke
Fields, J. D., Lindsay, K., Liu, K. C., Nesbit, G. M., & Lutsep, H. L. (2010) · Expert Review of Cardiovascular Therapy · doi:10.1586/erc.10.8 · Cited by 16
Metadata
- Authors
- Khatri, P., Abruzzo, T., Yeatts, S. D., Nichols, C., Broderick, J. P., & Tomsick, T. A.
- Venue
- Neurology
- Published
- 2009-09-29
- Volume
- 73
- Issue
- 13
- Pages
- 1066-1072
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2046468847
- Cited by
- 490
- References
- 34
- FWCI
- 21.80
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Khatri, P., Abruzzo, T., Yeatts, S. D., Nichols, C., Broderick, J. P., & Tomsick, T. A. (2009). Good clinical outcome after ischemic stroke with successful revascularization is time-dependent. Neurology. https://doi.org/10.1212/wnl.0b013e3181b9c847
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