Cited by 243Dementia and Cognitive Impairment ResearchCerebrovascular and genetic disordersNeurological Disease Mechanisms and Treatments

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Correlations between MRI white matter lesion location and executive function and episodic memory

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Smith, E.E., Salat, D.H., Jeng, J., McCreary, C.R., Fischl, B., Schmahmann, J.D., Dickerson, B.C., Viswanathan, A., Albert, M.S., Blacker, D., Greenberg, S.M.·2011·Neurology

DOI 10.1212/wnl.0b013e318217e7c8PMC PMC3087468

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Abstract

OBJECTIVES: MRI white matter hyperintensity (WMH) volume is associated with cognitive impairment. We hypothesized that specific loci of WMH would correlate with cognition even after accounting for total WMH volume. METHODS: Subjects were identified from a prospective community-based study: 40 had normal cognition, 94 had mild impairment (defined here as a Clinical Dementia Rating [CDR] score of 0.5 without dementia), and 11 had mild Alzheimer's dementia. Factor analysis of a 22-item neuropsychological battery yielded 4 factors (episodic memory, executive function, spatial skills, and general knowledge). MRI WMH segmentation and analysis was performed using FreeSurfer software. RESULTS: Higher WMH volume was independently associated with lower executive function and episodic memory factor scores. Voxel-based general linear models showed loci where WMH was strongly inversely associated with specific cognitive factor scores (p < 0.001), controlling for age, education, sex, APOE genotype, and total WMH volume. For episodic memory, clusters were observed in bilateral temporal-occipital and right parietal periventricular white matter, and the left anterior limb of the internal capsule. For executive function, clusters were observed in bilateral inferior frontal white matter, bilateral temporal-occipital and right parietal periventricular white matter, and the anterior limb of the internal capsule bilaterally. CONCLUSIONS: Specific WMH loci are closely associated with executive function and episodic memory, independent of total WMH volume. The anatomic locations suggest that WMH may cause cognitive impairment by affecting connections between cortex and subcortical structures, including the thalamus and striatum, or connections between the occipital lobe and frontal or parietal lobes.

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Authors: Smith, E. E., Salat, D. H., Jeng, J., McCreary, C. R., Fischl, B., Schmahmann, J. D., Dickerson, B. C., Viswanathan, A., Albert, M. S., Blacker, D., & Greenberg, S. M.
Affiliations: University of Calgary (CA)
ORCID: Smith, E.E.
Salat, D.H.
McCreary, C.R.
Fischl, B.
Schmahmann, J.D.
Dickerson, B.C.
Viswanathan, A.
Albert, M.S.
Blacker, D.
Greenberg, S.M.
Venue: Neurology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2011-04-26
Volume: 76
Issue: 17
Pages: 1492-1499
ISSN: 0028-3878 (ISSN-L)
1526-632X
DOI: 10.1212/wnl.0b013e318217e7c8
PMC: PMC3087468
OpenAlex: W2169452761
Cited by: 243
References: 42
Citations by year: 2026: 11 · 2025: 16 · 2024: 10 · 2023: 14 · 2022: 14 · 2021: 17 · 2020: 15 · 2019: 24 · 2018: 20 · 2017: 19 · 2016: 11 · 2015: 15 · 2014: 14 · 2013: 26 · 2012: 14
FWCI: 12.47
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Neurology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Alzheimer's Association
Dana Foundation
Sidney R. Baer, Jr. Foundation
Bristol-Myers Squibb
Eli Lilly and Company
Pfizer
University of Oxford
National Institutes of Health
Genentech
National Institute on Aging (R01AG26484, P01AG04953, R01AG026484, P01AG004953)
National Heart, Lung, and Blood Institute
National Institute of Neurological Disorders and Stroke (AG26484, R01NS062028)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Clinical Neurology › Cerebrovascular and genetic disorders
Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords: white matter hyperintensities, executive function, episodic memory, mild cognitive impairment, Alzheimer's disease, periventricular white matter, internal capsule, cognitive impairment
MeSH terms: Aged, Aged, 80 and over, Brain, Brain Mapping, Cognition Disorders, Female, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Memory Disorders, Nerve Fibers, Myelinated, Neuropsychological Tests, Mental Recall, Residence Characteristics, Statistics as Topic, Executive Function

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Correlations between MRI white matter lesion location and executive function and episodic memory

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