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Cited by 182Advanced Neuroimaging Techniques and ApplicationsDementia and Cognitive Impairment ResearchCognitive Abilities and Testing

Diffusion tensor imaging and cognitive function in older adults with no dementia

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Kantarci, K., Senjem, M.L., Avula, R., Zhang, B., Samikoglu, A.R., Weigand, S.D., Przybelski, S.A., Edmonson, H.A. +7 more·2011·Neurology
DOI 10.1212/wnl.0b013e31822313dcPMC PMC3127333
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Abstract

OBJECTIVE: To determine the patterns of diffusivity associated with cognitive domain functions in older adults without dementia. METHODS: We studied older adults without dementia (n = 220) who underwent neuropsychometric testing and a diffusion tensor imaging (DTI) examination at 3 T in a cross-sectional study. Memory, language, attention/executive function, and visual-spatial processing domains were assessed within 4 months of the MRI examination. A fluid-attenuated inversion recovery-based DTI sequence that enabled uncontaminated cortical diffusion measurements was performed. Associations between cortical mean diffusivity (MD) and cognitive function were tested using voxel-based regression analysis. Association between tract diffusivity and cognitive function was tested with regions of interest drawn on color-coded fractional anisotropy (FA) maps. RESULTS: Memory function was associated with the medial temporal lobe cortical MD on voxel-based analysis (p < 0.001, corrected for multiple comparisons), and inferior longitudinal fasciculus and posterior and anterior cingulum FA on tract-based analysis (p < 0.001). Language function was associated with the left temporal lobe cortical MD (p < 0.001, corrected for multiple comparisons), inferior longitudinal fasciculus, fornix, and posterior cingulum FA (p < 0.05). Attention and executive function was associated with the posterior and anterior cingulum FA, and visual-spatial function was associated with posterior cingulum FA (p < 0.01). CONCLUSION: Specific cognitive domain functions are associated with distinct patterns of cortical and white matter diffusivity in elderly with no dementia. Posterior cingulum tract FA was associated with all 4 cognitive domain functions, in agreement with the hypothesis that the posterior cingulate cortex is the main connectivity hub for cognitive brain networks. Microstructural changes identified on DTI may be associated with neurodegenerative pathologies underlying cognitive changes in older adults without dementia.

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  • Kantarci et al. (2011) found FA differences in the anterior cingulum correlate with differences in attention/executive and memory performance, while FA in the posterior dorsal cingulum appeared to contribute to all four cognitive domains.

    “They found FA differences in the anterior cingulum to correlate with differences in attention/executive and memory performance, while FA in the posterior dorsal cingulum appeared to contribute to all four cognitive domains.”

    From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Kantarci et al., 2011

    The attention/executive results and Table 2 report correlations between anterior cingulum FA and both attention/executive and memory performance. The Abstract and Figure 1 passage report that posterior cingulum FA was associated with all four cognitive domains. The paper does not identify that posterior cingulum measurement as dorsal; its reference to a dorsal component concerns the superior longitudinal fasciculus. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

  • Cingulum associations with episodic memory are not always observed in healthy older individuals nor are they always confined to its parahippocampal subdivision.

    “However, such cingulum associations with episodic memory are not always observed in healthy older individuals (Metzler-Baddeley et al., 2011) nor are they always confined to its parahippocampal subdivision (e.g., Kantarci et al., 2011).”

    From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Kantarci et al., 2011

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Authors
Kantarci, K., Senjem, M. L., Avula, R., Zhang, B., Samikoglu, A. R., Weigand, S. D., Przybelski, S. A., Edmonson, H. A., Vemuri, P., Knopman, D. S., Boeve, B. F., Ivnik, R. J., Smith, G. E., Petersen, R. C., & Jack, C. R.
Affiliations
Mayo Clinic (US)
ORCID
Venue
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2011-07-05
Volume
77
Issue
1
Pages
26-34
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
DOI
10.1212/wnl.0b013e31822313dc
PMC
PMC3127333
OpenAlex
W2082533002
Cited by
182
References
40
Citations by year
2026: 4 · 2025: 9 · 2024: 8 · 2023: 18 · 2022: 9 · 2021: 10 · 2020: 17 · 2019: 14 · 2018: 4 · 2017: 10 · 2016: 12 · 2015: 10 · 2014: 18 · 2013: 21 · 2012: 15
FWCI
13.71
Type
journal article
Language
en
Open access
Locations
  • Neurology (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Alzheimer's Association
  • Eli Lilly and Company
  • Pfizer
  • Baxter International
  • Mayo Foundation for Medical Education and Research (AG16574)
  • National Alliance for Research on Schizophrenia and Depression
  • University of Oxford
  • Eisai
  • National Institutes of Health (AG11378, P50 AG16574/P1, R01 AG11378, AG16574)
  • Forest Laboratories
  • National Institute on Aging (R01AG11378, K23AG030935, P50‐AG16574, U01AG06786, AG-06786, P50 AG16574/P1, AG 16574, U01AG006786, R01AG011378, AG-11378, P50AG016574)
  • National Institute of Mental Health
  • National Institute of Neurological Disorders and Stroke
  • National Institute of Biomedical Imaging and Bioengineering
  • National Center for Research Resources (RR018898, C06RR018898)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
Keywords
diffusion tensor imaging, cognitive function, older adults without dementia, mean diffusivity, fractional anisotropy, posterior cingulum, posterior cingulate cortex, inferior longitudinal fasciculus, fornix, white matter microstructure, memory, language, attention and executive function, visuospatial processing, neurodegeneration
MeSH terms
Aged, Aged, 80 and over, Aging, Brain Mapping, Cognition Disorders, Female, Humans, Image Processing, Computer-Assisted, Language Disorders, Male, Memory Disorders, Middle Aged, Nerve Fibers, Myelinated, Neuropsychological Tests, Space Perception, Anisotropy, Diffusion Tensor Imaging

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