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Cited by 17Multiple Sclerosis Research StudiesOcular Diseases and Behçet’s SyndromePeripheral Neuropathies and Disorders

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Value of NMO-IgG determination at the time of presentation as CIS

Costa, C., Arrambide, G., Tintore, M., Castilló, J., Sastre-Garriga, J., Tur, C., Río, J., Saiz, A., Vidal-Jordana, A., Auger, C., Nos, C., Rovira, A., Comabella, M., Horga, A., Montalban, X.·2012·Neurology
DOI 10.1212/wnl.0b013e3182563b32
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Abstract

Background Despite the availability of diagnostic criteria, an overlap between neuromyelitis optica (NMO) and multiple sclerosis (MS) exists, particularly in the early stage of the disease. Objective To study the value of NMO-immunoglobulin G (IgG) determination in Caucasian patients with a first demyelinating episode who develop a relapsing form of optic neuritis or myelitis. Methods This study was based on a prospectively acquired cohort of patients regarded as having a clinically isolated syndrome (CIS) at the time of presentation. From this cohort, 2 different groups were selected: group 1 (NMO phenotype), consisting of a first attack involving the optic nerve or the spinal cord, and at least a second event affecting either topography, and group 2 (negative control group), consisting of a first attack involving the brainstem or the cerebral hemispheres and at least 1 relapse in any topography. Group 3 was composed of patients with NMO according to the 2006 revised diagnostic criteria. Serum NMO-IgG was determined by indirect immunofluorescence. Results A total of 3.1 of the group 1 patients were positive for NMO-IgG in comparison to 3.9% of group 2 and 44.5% of group 3, NMO. One of the positive patients in group 1 evolved to NMO. Conclusions NMO-IgG determination is crucial in detecting patients who will develop NMO; however, its value as a routine test in cases presenting with symptoms of the type seen in MS is low, and should only be performed in those patients in which…

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Crossref · 10.1212/wnl.0b013e3182563b32

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  • Although the first attack of NMOSD can mimic CIS, routine testing for AQP4-IgG in CIS populations with a high incidence of MS and low incidence of NMOSD has a very low yield and is not recommended.

    “Although the first attack of NMOSD can mimic CIS (e.g.acute unilateral optic neuritis or short-segment partial myelitis 61 ), routine testing for AQP4-IgG in CIS populations with a high incidence of MS and low incidence of NMOSD has a very low yield and is not recommended.62”

    From Diagnosis of multiple sclerosis: progress and challenges (2017) · cites this paper as [62]

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Metadata

Authors
Costa, C., Arrambide, G., Tintore, M., Castilló, J., Sastre-Garriga, J., Tur, C., Río, J., Saiz, A., Vidal-Jordana, A., Auger, C., Nos, C., Rovira, A., Comabella, M., Horga, A., & Montalban, X.
Affiliations
  • Universitat Autònoma de Barcelona (ES)
  • From the Unitat de Neuroimmunologia Clinica (UNiC), Centre d'Esclerosi Múltiple de Catalunya (CEM-Cat), Vall d'Hebron Institut de Recerca (VHIR) (C.C., G.A., M.T., J.C., J.S.-G., C.T., J.R., A.V.-J., C.N., M.C., A.H., X.M.), and Magnetic Resonance Unit (IDI), Department of Radiology (C.A., A.R.), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona; and Service of Neurology (A.S.), Hospital Clinic, Universitat de Barcelona and Institut d' Investigació Biomèdica August Pi i Sunyer ...
ORCID
Venue
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2012-05-15
Volume
78
Issue
20
Pages
1608-1611
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
DOI
10.1212/wnl.0b013e3182563b32
OpenAlex
W2137131203
Cited by
17
References
10
Citations by year
2024: 1 · 2022: 1 · 2018: 2 · 2017: 1 · 2016: 4 · 2015: 3 · 2014: 3 · 2013: 1 · 2012: 1
FWCI
1.85
Type
journal article
Language
en
Open access
closed
Locations
  • Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
  • Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
  • Health Sciences › Medicine › Clinical Neurology › Peripheral Neuropathies and Disorders
Keywords
neuromyelitis optica, aquaporin-4 antibodies, clinically isolated syndrome, multiple sclerosis, serological diagnosis, optic neuritis, myelitis, demyelinating disease, diagnostic criteria, disease progression
MeSH terms
Adolescent, Adult, Demyelinating Diseases, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuromyelitis Optica, Retrospective Studies, Time Factors, Cohort Studies, Oligoclonal Bands, White People, Aquaporin 4, Young Adult

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