Cited by 236Congenital Heart Disease StudiesNeonatal and fetal brain pathologyFetal and Pediatric Neurological Disorders

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Brain injury and development in newborns with critical congenital heart disease

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Dimitropoulos, Anastasia, McQuillen, Patrick S., Sethi, Viyeka, Moosa, Alisha, Chau, Vann, Xu, Duan, Brant, Rollin, Azakie, Anthony, Campbell, Andrew, Barkovich, A. James, Poskitt, Kenneth J., Miller, Steven P.·2013·Neurology

DOI 10.1212/wnl.0b013e31829bfdcfPMC PMC3770166

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Abstract

OBJECTIVE: To determine the relationship between radiologically identifiable brain injuries and delayed brain development as reflected by brain metabolic and microstructural integrity. METHODS: Term newborns with congenital heart disease (CHD) (120 preoperatively and 104 postoperatively) were studied with MRI to determine brain injury severity (BIS), microstructure reflected by fractional anisotropy (FA) and average diffusivity (Dav), and metabolism reflected by N-acetylaspartate (NAA)/choline (Cho) and lactate/Cho. Brain development is characterized by increasing NAA/Cho and white matter FA, and by decreasing Dav and lactate/Cho. RESULTS: Newly acquired brain injury was common (41% preoperative, 30% postoperative). Lower white matter FA (p = 0.005) and lower NAA/Cho (p = 0.01) were associated with increasing preoperative BIS. Higher neonatal illness severity scores (p = 0.03), lower preoperative oxygen saturation (p = 0.002), hypotension (p < 0.001), and septostomy (p = 0.002) were also predictive of higher preoperative BIS. Preoperative FA, Dav, and NAA/Cho did not predict new postoperative BIS. Increasing preoperative BIS predicted higher postoperative Dav (p = 0.002) and lactate/Cho (p = 0.008). Within the postoperative scan, new brain injuries were associated with lower white matter FA (p = 0.04). Postoperative BIS (new lesions) was associated with lower postoperative systolic (p = 0.03) and mean (p = 0.05) blood pressures. CONCLUSIONS: Brain injuries in newborns with CHD are strongly related to abnormalities of brain microstructural and metabolic brain development, especially preoperatively. Both newly acquired preoperative and postoperative brain injuries are related to potentially modifiable clinical risk factors.

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Papile, L. A., Burstein, J., Burstein, R., & Koffler, H. (1978) · The Journal of Pediatrics · doi:10.1016/s0022-3476(78)80282-0 · Cited by 6,435
The basis of anisotropic water diffusion in the nervous system—A technical review.
Beaulieu, C. (2002) · NMR in Biomedicine · doi:10.1002/nbm.782 · Cited by 4,628
Models for Longitudinal Data: A Generalized Estimating Equation Approach
Zeger, S. L., Liang, K., & Albert, P. S. (1988) · Biometrics · doi:10.2307/2531734 · Cited by 4,505
Abnormal brain development in newborns with congenital heart disease
Miller, S. P., McQuillen, P. S., Hamrick, S., Xu, D., Glidden, D. V., Charlton, N., Karl, T., Azakie, A., Ferriero, D. M., Barkovich, A. J., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa067393 · Cited by 860
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Bellinger, D. C., Jonas, R. A., Rappaport, L., Wypij, D., Wernovsky, G., Kuban, K., Barnes, P. D., Holmes, G. L., Hickey, P. R., Strand, R. D., et al. (1995) · New England Journal of Medicine · doi:10.1056/nejm199503023320901 · Cited by 803
Neural activity triggers neuronal oxidative metabolism followed by astrocytic glycolysis
Kasischke, K. A., Vishwasrao, H. D., Fisher, P. J., Zipfel, W. R., & Webb, W. W. (2004) · Science · doi:10.1126/science.1096485 · Cited by 742
Neurodevelopmental status at eight years in children with dextro-transposition of the great arteries: The Boston Circulatory Arrest Trial
Bellinger, D. C., Wypij, D., duPlessis, A. J., Rappaport, L. A., Jonas, R. A., Wernovsky, G., & Newburger, J. W. (2003) · The Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(03)00711-6 · Cited by 681
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Licht, D. J., Shera, D. M., Clancy, R. R., Wernovsky, G., Montenegro, L. M., Nicolson, S. C., Zimmerman, R. A., Spray, T. L., Gaynor, J. W., & Vossough, A. (2009) · The Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2008.10.025 · Cited by 629
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Pulcine, E., & deVeber, G. (2021) · Handbook of clinical neurology · doi:10.1016/b978-0-12-819814-8.00010-x · Cited by 1
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Reitz, J. G., & Yerebakan, C. (2020) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2020.11.079 · Cited by 1
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Seed, M., Ilardi, D. L., Rofeberg, V., Ortinau, C. M., Goldberg, C., Reichle, G., Elhoff, J. J., Lisanti, A. J., Butcher, J. L., Rollins, C. K., et al. (2025) · medRxiv · doi:10.1101/2025.03.03.25323281 · Cited by 1

Authors: Dimitropoulos, A., McQuillen, P. S., Sethi, V., Moosa, A., Chau, V., Xu, D., Brant, R., Azakie, A., Campbell, A., Barkovich, A. J., Poskitt, K. J., & Miller, S. P.
Affiliations: University of British Columbia (CA)
ORCID: Dimitropoulos, Anastasia
McQuillen, Patrick S.
Chau, Vann
Xu, Duan
Brant, Rollin
Campbell, Andrew
Barkovich, A. James
Miller, Steven P.
Venue: Neurology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2013-07-16
Volume: 81
Issue: 3
Pages: 241-248
ISSN: 0028-3878 (ISSN-L)
1526-632X
DOI: 10.1212/wnl.0b013e31829bfdcf
PMC: PMC3770166
OpenAlex: W1996831127
Cited by: 236
References: 39
Citations by year: 2026: 16 · 2025: 13 · 2024: 10 · 2023: 22 · 2022: 26 · 2021: 21 · 2020: 22 · 2019: 28 · 2018: 22 · 2017: 15 · 2016: 12 · 2015: 17 · 2014: 10 · 2013: 2
FWCI: 9.96
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Neurology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: Canadian Institutes of Health Research (MOP93780)
National Institute of Neurological Disorders and Stroke (R01NS063876, R01NS40117, P50-NS35902, R01NS040117, P50NS035902)
National Center for Research Resources (M01RR001271, 5M01RR-01271)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Congenital Heart Disease Studies
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
Keywords: congenital heart disease, neonatal brain injury, brain development, white matter microstructure, fractional anisotropy, N-acetylaspartate, lactate, brain metabolism, hypoxia, hypotension, septostomy, neonatal surgery, risk factors
MeSH terms: Brain Injuries, Female, Heart Defects, Congenital, Humans, Infant, Newborn, Magnetic Resonance Imaging, Male, Nerve Fibers, Myelinated, Risk Factors, Anisotropy

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Brain injury and development in newborns with critical congenital heart disease

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