The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Impaired default network functional connectivity in autosomal dominant Alzheimer disease
Open accessAbstract
OBJECTIVE: To investigate default mode network (DMN) functional connectivity MRI (fcMRI) in a large cross-sectional cohort of subjects from families harboring pathogenic presenilin-1 (PSEN1), presenilin-2 (PSEN2), and amyloid precursor protein (APP) mutations participating in the Dominantly Inherited Alzheimer Network. METHODS: Eighty-three mutation carriers and 37 asymptomatic noncarriers from the same families underwent fMRI during resting state at 8 centers in the United States, United Kingdom, and Australia. Using group-independent component analysis, fcMRI was compared using mutation status and Clinical Dementia Rating to stratify groups, and related to each participant's estimated years from expected symptom onset (eYO). RESULTS: We observed significantly decreased DMN fcMRI in mutation carriers with increasing Clinical Dementia Rating, most evident in the precuneus/posterior cingulate and parietal cortices (p < 0.001). Comparison of asymptomatic mutation carriers with noncarriers demonstrated decreased fcMRI in the precuneus/posterior cingulate (p = 0.014) and right parietal cortex (p = 0.0016). We observed a significant interaction between mutation carrier status and eYO, with decreases in DMN fcMRI observed as mutation carriers approached and surpassed their eYO. CONCLUSION: Functional disruption of the DMN occurs early in the course of autosomal dominant Alzheimer disease, beginning before clinically evident symptoms, and worsening with increased impairment. These findings suggest that DMN fcMRI may prove useful as a biomarker across a wide spectrum of disease, and support the feasibility of DMN fcMRI as a secondary endpoint in upcoming multicenter clinical trials in Alzheimer disease.
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“our findings support the possibility that callosal white matter degeneration contribute to functional disruption of functional networks such as the default mode network (Chhatwal et al., 2013; Mueller and Weiner, 2017; Taylor et al., 2017)”
From White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer’s disease (2018) · cites this paper as Chhatwal et al., 2013
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“a functional network showing reduced connectivity in early-stage Alzheimer’s disease (Sorg et al., 2007; Chhatwal et al., 2013)”
From White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer’s disease (2018) · cites this paper as Chhatwal et al., 2013
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Lecture Notes in Computer Science 1205
(1999) · Industrial Robot the international journal of robotics research and application · doi:10.1108/ir.1999.04926fae.001 · Cited by 39,228
The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics
Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864
Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359
The organization of the human cerebral cortex estimated by intrinsic functional connectivity
Thomas Yeo, B. T., Krienen, F. M., Sepulcre, J., Sabuncu, M. R., Lashkari, D., Hollinshead, M., Roffman, J. L., Smoller, J. W., Zöllei, L., Polimeni, J. R., et al. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00338.2011 · Cited by 9,182
The human brain is intrinsically organized into dynamic, anticorrelated functional networks
Fox, M. D., Snyder, A. Z., Vincent, J. L., Corbetta, M., Van Essen, D. C., & Raichle, M. E. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504136102 · Cited by 8,553
The organization of the human cerebellum estimated by intrinsic functional connectivity
Buckner, R. L., Krienen, F. M., Castellanos, A., Diaz, J. C., & Yeo, B. T. T. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00339.2011 · Cited by 7,304
Sperling, R. A., Aisen, P. S., Beckett, L. A., Bennett, D. A., Craft, S., Fagan, A. M., Iwatsubo, T., Jack, C. R., Kaye, J., Montine, T. J., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.003 · Cited by 7,155
Self-citationFunctional connectivity in the resting brain: a network analysis of the default mode hypothesis
Greicius, M. D., Krasnow, B., Reiss, A. L., & Menon, V. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0135058100 · Cited by 6,358
Gauthier, S. G., Reisberg, ., Zaudig, M., Petersen, R. C., Ritchie, K. A., Broich, K., Belleville, S., Brodaty, H., Bennett, D. A., Chertkow, H. M., et al. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68542-5 · Cited by 4,094
Clinical and biomarker changes in dominantly inherited Alzheimer's disease
Bateman, R. J., Xiong, C., Benzinger, T. L. S., Fagan, A. M., Goate, A., Fox, N. C., Marcus, D. S., Cairns, N. J., Xie, X., Blazey, T. M., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1202753 · Cited by 3,814
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Research works printed but not linked: 1
- Thomas JB Brier MR Bateman RJ et al.. Functional connectivity in autosomal dominant and sporadic Alzheimer disease. Presented at the Alzheimer's Association International Conference; July 13–18 2013; Boston.
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Sperling, R., Mormino, E., & Johnson, K. (2014) · Neuron · doi:10.1016/j.neuron.2014.10.038 · Cited by 725
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Badhwar, A., Tam, A., Dansereau, C. L., Orban, P., Hoffstaedter, F., & Bellec, P. (2017) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2017.03.007 · Cited by 453
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Metadata
- Authors
- Chhatwal, J. P., Schultz, A. P., Johnson, K., Benzinger, T. L. S., Jack, C., Ances, B. M., Sullivan, C. A., Salloway, S. P., Ringman, J. M., Koeppe, R. A., Marcus, D. S., Thompson, P., Saykin, A. J., Correia, S., Schofield, P. R., Rowe, C. C., Fox, N. C., Brickman, A. M., Mayeux, R., McDade, E., Bateman, R., Fagan, A. M., Goate, A. M., Xiong, C., Buckles, V. D., Morris, J. C., & Sperling, R. A.
- Affiliations
- Harvard University (US)
- From the Departments of Neurology (J.P.C., A.P.S., K.J., C.A.S., R.A.S.) and Radiology (K.J.), and Martinos Center for Biomedical Imaging (J.P.C., A.P.S., K.J., C.A.S., R.A.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Radiology, Section of Neuroradiology (T.L.S.B., D.S.M.), Mallinckrodt Institute of Radiology (T.L.S.B., B.M.A., D.S.M.), Departments of Neurology (B.M.A., R.B., A.M.F., V.D.B., J.C.M.), Genetics (A.M.G.), and Psychiatry (A.M.G.), and Division of...
- ORCID
- Chhatwal, Jasmeer P.
- Schultz, Aaron P.
- Johnson, Keith
- Benzinger, Tammie L.S.
- Jack, Clifford
- Ances, Beau M.
- Salloway, Stephen P.
- Ringman, John M.
- Koeppe, Robert A.
- Marcus, Daniel S.
- Thompson, Paul
- Saykin, Andrew J.
- Correia, Stephen
- Schofield, Peter R.
- Fox, Nick C.
- Brickman, Adam M.
- Mayeux, Richard
- McDade, Eric
- Bateman, Randall
- Fagan, Anne M.
- Xiong, Chengjie
- Morris, John C.
- Sperling, Reisa A.
- Venue
- Neurology
- Published
- 2013-08-20
- Volume
- 81
- Issue
- 8
- Pages
- 736-744
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- PMC
- PMC3776464
- OpenAlex
- W2165942026
- Cited by
- 179
- References
- 42
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 8 · 2023: 10 · 2022: 10 · 2021: 14 · 2020: 11 · 2019: 33 · 2018: 18 · 2017: 19 · 2016: 10 · 2015: 12 · 2014: 24 · 2013: 1
- FWCI
- 8.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neurology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- National Institute for Health and Care Research (NF-SI-0508-10123)
- National Institute on Aging (K24AG035007, P50AG005134, U19AG032438, U24AG021886, P30AG062421)
- National Institute of Nursing Research (R01NR012657)
- National Institute of Neurological Disorders and Stroke (P30NS048056)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- autosomal dominant Alzheimer's disease, default mode network, functional connectivity, presenilin 1 mutations, amyloid precursor protein mutations, mutation carriers, asymptomatic carriers, precuneus, posterior cingulate cortex, parietal cortex, Clinical Dementia Rating, early biomarkers
- MeSH terms
- Adult, Alzheimer Disease, Brain, Female, Genes, Dominant, Heterozygote, Humans, Male, Nerve Net, Prevalence, Amyloid beta-Protein Precursor, Genetic Predisposition to Disease, Internationality, Presenilin-1, Presenilin-2, Connectome
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