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Is the mesocortical dopaminergic system involved in Parkinson disease?
Abstract
Tyrosine hydroxylase was used to identify catecholaminergic neurons in the substantia nigra and ventral tegmental area of the human mesencephalon. High enzyme activity in the normal ventral tegmental area indicated the presence of numerous cathecholaminergic neurons, most likely dopamine cells. Tyrosine-hydroxylase activity was decreased in the ventral tegmental area of parkinsonian patients, implying a lesion of the mesocortical dopamine system in Parkinson disease.
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Cited by
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Metadata
- Authors
- Javoy-Agid, F., & Agid, Y.
- Venue
- Neurology
- Published
- 1980-12
- Volume
- 30
- Issue
- 12
- Pages
- 1326-1326
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2032984859
- Cited by
- 413
- References
- 0
- FWCI
- 13.17
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
