Lipopolysaccharide-induced neuroinflammation as a bridge to understand neurodegeneration
Open accessAbstract
A large body of experimental evidence suggests that neuroinflammation is a key pathological event triggering and perpetuating the neurodegenerative process associated with many neurological diseases. Therefore, different stimuli, such as lipopolysaccharide (LPS), are used to model neuroinflammation associated with neurodegeneration. By acting at its receptors, LPS activates various intracellular molecules, which alter the expression of a plethora of inflammatory mediators. These factors, in turn, initiate or contribute to the development of neurodegenerative processes. Therefore, LPS is an important tool for the study of neuroinflammation associated with neurodegenerative diseases. However, the serotype, route of administration, and number of injections of this toxin induce varied pathological responses. Thus, here, we review the use of LPS in various models of neurodegeneration as well as discuss the neuroinflammatory mechanisms induced by this toxin that could underpin the pathological events linked to the neurodegenerative process.
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Peripheral administration of LPS is widely used to model brain inflammation associated with neurodegenerative disease.
“Peripheral administration of LPS is widely used to model brain inflammation associated with neurodegenerative disease”
From Molecular and spatial signatures of mouse brain aging at single-cell resolution (2023) · cites this paper as [46]
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Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · cited 1× · see citing works
“AD is associated with neuropathological changes such as the formation of tau aggregates seen as intraneuronal neurofibrillary tangles and the presence of extracellular amyloid-beta (Aβ) plaques [17,18].”
BackgroundAmyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359 · see citing works
Polazzi, E., Mengoni, I., Caprini, M., Peña‐Altamira, E., Kurtys, E., & Monti, B. (2012) · Neurosignals · doi:10.1159/000337115 · Cited by 9,023 · see citing works
MACDONALD, M. (1993) · Cell · doi:10.1016/0092-8674(93)90585-e · Cited by 8,366 · see citing works
Dauer, W., & Przedborski, S. (2003) · Neuron · doi:10.1016/s0896-6273(03)00568-3 · Cited by 5,469 · see citing works
Poewe, W., Seppi, K., Tanner, C. M., Halliday, G. M., Brundin, P., Volkmann, J., Schrag, A.-E., & Lang, A. E. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.13 · Cited by 5,415 · see citing works
Motor Neuron Degeneration in Mice that Express a Human Cu,Zn Superoxide Dismutase Mutation
Gurney, M. E., Pu, H., Chiu, A. Y., Dal Canto, M. C., Polchow, C. Y., Alexander, D. D., Caliendo, J., Hentati, A., Kwon, Y. W., Deng, H.-X., et al. (1994) · Science · doi:10.1126/science.8209258 · Cited by 4,143 · see citing works
NF-κB: a key role in inflammatory diseases
Tak, P. P., & Firestein, G. S. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11830 · Cited by 3,918 · see citing works
Mechanisms underlying inflammation in neurodegeneration
Glass, C. K., Saijo, K., Winner, B., Marchetto, M. C., & Gage, F. H. (2010) · Cell · doi:10.1016/j.cell.2010.02.016 · Cited by 3,580 · see citing works
Shah, M. A., Datson, N. A., Srinidhi, L., Stanton, V. P., MacDonald, M. E., Allard, M. W., Youngman, S., Am, F., Mott, R., Draths, K., et al. (1993) · Cell · Cited by 3,055 · see citing works
McGeer, P. L., Itagaki, S., Boyes, B. E., & McGeer, E. G. (1988) · Neurology · doi:10.1212/wnl.38.8.1285 · Cited by 2,990 · see citing works
Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism
Bonifati, V., Rizzu, P., van Baren, M. J., Schaap, O., Breedveld, G. J., Krieger, E., Dekker, M. C. J., Squitieri, F., Ibáñez, P., Joosse, M., et al. (2003) · Science · doi:10.1126/science.1077209 · Cited by 2,800 · see citing works
Parkinson, J. (2002) · Journal of Neuropsychiatry · doi:10.1176/jnp.14.2.223 · Cited by 2,684 · see citing works
IKKε and TBK1 are essential components of the IRF3 signaling pathway
Fitzgerald, K. A., McWhirter, S. M., Faia, K. L., Rowe, D. C., Latz, E., Golenbock, D. T., Coyle, A. J., Liao, S.-M., & Maniatis, T. (2003) · Nature Immunology · doi:10.1038/ni921 · Cited by 2,680 · see citing works
Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration
Qin, L., Wu, X., Block, M. L., Liu, Y., Breese, G. R., Hong, J., Knapp, D. J., & Crews, F. T. (2007) · Glia · doi:10.1002/glia.20467 · Cited by 2,144 · see citing works
Immune attack: the role of inflammation in Alzheimer disease
Heppner, F. L., Ransohoff, R. M., & Becher, B. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3880 · Cited by 2,134 · see citing works
Nelson, P. T., Alafuzoff, I., Bigio, E. H., Bouras, C., Braak, H., Cairns, N. J., Castellani, R. J., Crain, B. J., Davies, P., Tredici, K. D., et al. (2012) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31825018f7 · Cited by 2,050 · cited 1× · see citing works
“It is characterized by the inability to form new memories, reflecting the dysfunction of the episodic memory system [15,16].”
BackgroundHow neuroinflammation contributes to neurodegeneration
Ransohoff, R. M. (2016) · Science · doi:10.1126/science.aag2590 · Cited by 1,967 · cited 1× · see citing works
“Several lines of experimental evidence have demonstrated that neuronal cell death may induce an inflammatory process, and inflammation by itself may lead to cell death [1].”
BackgroundMicroglia emerge as central players in brain disease
Salter, M. W., & Stevens, B. (2017) · Nature Medicine · doi:10.1038/nm.4397 · Cited by 1,767 · see citing works
p38 MAP-Kinases pathway regulation, function and role in human diseases
Cuenda, A., & Rousseau, S. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2007.03.010 · Cited by 1,397 · see citing works
Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease
Ittner, L. M., & Götz, J. (2010) · Nature reviews. Neuroscience · doi:10.1038/nrn2967 · Cited by 1,357 · see citing works
Zhang, W., Wang, T., Pei, Z., Miller, D. S., Wu, X., Block, M. L., Wilson, B., Zhang, W., Zhou, Y., Hong, J.-S., et al. (2005) · The FASEB Journal · doi:10.1096/fj.04-2751com · Cited by 1,265 · see citing works
Recognition of lipopolysaccharide pattern by TLR4 complexes
Park, B. S., & Lee, J. (2013) · Experimental & Molecular Medicine · doi:10.1038/emm.2013.97 · Cited by 1,244 · see citing works
Mrdjen, D., Pavlovic, A., Hartmann, F. J., Schreiner, B., Utz, S. G., Leung, B. P., Lelios, I., Heppner, F. L., Kipnis, J., Merkler, D., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.01.011 · Cited by 1,010 · see citing works
Nalls, M., Plagnol, V., Hernandez, D., Sharma, M., Sheerin, U., Saad, M., Simón-Sánchez, J., Schulte, C., Lesage, S., Sveinbjörnsdóttir, S., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(10)62345-8 · Cited by 986 · see citing works
Inflammation in Alzheimer Disease--A Brief Review of the Basic Science and Clinical Literature
Wyss-Coray, T., & Rogers, J. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006346 · Cited by 975 · see citing works
A pathophysiological framework of hippocampal dysfunction in ageing and disease
Small, S. A., Schobel, S., Buxton, R. B., Witter, M. P., & Barnes, C. A. (2011) · Nature reviews. Neuroscience · doi:10.1038/nrn3085 · Cited by 920 · see citing works
Kim, W., Mohney, R. P., Wilson, B. C., Jeohn, G., Liu, B., & Hong, J. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-16-06309.2000 · Cited by 881 · see citing works
Lee, J. W., Lee, Y. K., Yuk, D. Y., Choi, D. Y., Ban, S. B., Oh, K. W., & Hong, J. T. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-37 · Cited by 772 · see citing works
Bhat, N. R., Zhang, P., Lee, J. C., & Hogan, E. L. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-05-01633.1998 · Cited by 714 · see citing works
Kitazawa, M., Oddo, S., Yamasaki, T. R., Green, K. N., & LaFerla, F. M. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2868-05.2005 · Cited by 697 · see citing works
Gao, H., Jiang, J., Wilson, B. C., Zhang, W., Hong, J., & Liu, B. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00928.x · Cited by 690 · see citing works
Immune activation in brain aging and neurodegeneration: too much or too little?
Lucin, K. M., & Wyss-Coray, T. (2009) · Neuron · doi:10.1016/j.neuron.2009.08.039 · Cited by 679 · see citing works
Neuroinflammation Induces Neurodegeneration.
Kempuraj, D., Thangavel, R., Natteru, P., Selvakumar, G. P., Saeed, D., Zahoor, H., Zaheer, S., Iyer, S. S., & Zaheer, A. (2016) · PubMed · Cited by 672 · see citing works
Memory loss in Alzheimer's disease
Jahn, H. (2013) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2013.15.4/hjahn · Cited by 653 · see citing works
Björkqvist, M., Wild, E. J., Thiele, J., Silvestroni, A., André, R., Lahiri, N., Raibon, E., Lee, R. V., Benn, C., Soulet, D., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080178 · Cited by 646 · see citing works
Toll-like receptors modulate adult hippocampal neurogenesis
Rolls, A., Shechter, R., London, A., Ziv, Y., Ronen, A., Levy, R., & Schwartz, M. (2007) · Nature Cell Biology · doi:10.1038/ncb1629 · Cited by 620 · see citing works
Perry, V. H. (2004) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2004.01.004 · Cited by 560 · see citing works
Huntingtin–protein interactions and the pathogenesis of Huntington's disease
Li, S.-H., & Li, X. (2004) · Trends in Genetics · doi:10.1016/j.tig.2004.01.008 · Cited by 548 · see citing works
Transcriptional abnormalities in Huntington disease
Sugars, K. L., & Rubinsztein, D. C. (2003) · Trends in Genetics · doi:10.1016/s0168-9525(03)00074-x · Cited by 529 · see citing works
Gram-negative bacterial molecules associate with Alzheimer disease pathology
Zhan, X., Stamova, B., Jin, L.-W., DeCarli, C., Phinney, B., & Sharp, F. R. (2016) · Neurology · doi:10.1212/wnl.0000000000003391 · Cited by 521 · see citing works
Park, J.-S., Davis, R. L., & Sue, C. M. (2018) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-018-0829-3 · Cited by 516 · see citing works
Interleukin‐6 and α‐2‐macroglobulin indicate an acute‐phase state in Alzheimer's disease cortices
Bauer, J., Strauss, S., Schreiter-Gasser, U., Ganter, U., Schlegel, P., Witt, I., Yolk, B., & Berger, M. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)80737-n · Cited by 483 · see citing works
TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins
Meseguer, V., Alpizar, Y. A., Luis, E., Tajada, S., Denlinger, B., Fajardo, O., Manenschijn, J.-A., Fernández-Peña, C., Talavera, A., Kichko, T., et al. (2014) · Nature Communications · doi:10.1038/ncomms4125 · Cited by 479 · see citing works
LRRK2 Inhibition Attenuates Microglial Inflammatory Responses
Moehle, M. S., Webber, P. J., Tse, T., Sukar, N., Standaert, D. G., DeSilva, T. M., Cowell, R. M., & West, A. B. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.5601-11.2012 · Cited by 463 · see citing works
Toll-Like Receptors in Neurodegeneration
Okun, E., Griffioen, K., Lathia, J., Tang, S.-C., Mattson, M., & Arumugam, T. (2008) · Brain Research Reviews · doi:10.1016/j.brainresrev.2008.09.001 · Cited by 459 · see citing works
Mitochondrial Dysfunction in Parkinson’s Disease
Moon, H. E., & Paek, S. H. (2015) · Experimental Neurobiology · doi:10.5607/en.2015.24.2.103 · Cited by 455 · see citing works
Immune reactivity in a mouse model of familial ALS correlates with disease progression
Alexianu, M. E., Kozovska, M., & Appel, S. H. (2001) · Neurology · doi:10.1212/wnl.57.7.1282 · Cited by 438 · see citing works
α-Synuclein and neuronal cell death
Cookson, M. (2009) · Molecular Neurodegeneration · doi:10.1186/1750-1326-4-9 · Cited by 420 · see citing works
Is the mesocortical dopaminergic system involved in Parkinson disease?
Javoy-Agid, F., & Agid, Y. (1980) · Neurology · doi:10.1212/wnl.30.12.1326 · Cited by 417 · see citing works
Glial cytokines in Alzheimer's disease: Review and pathogenic implications
Mrak, R. E., Sheng, J. G., & Griffin, W. S. T. (1995) · Human Pathology · doi:10.1016/0046-8177(95)90001-2 · Cited by 414 · see citing works
Castaño, A., Herrera, A. J., Cano, J., & Machado, A. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70041584.x · Cited by 393 · see citing works
Herrera, A. J., Castaño, A., Venero, J. L., Cano, J., & Machado, A. (2000) · Neurobiology of Disease · doi:10.1006/nbdi.2000.0289 · Cited by 392 · see citing works
Sheng, J. (2003) · Neurobiology of Disease · doi:10.1016/s0969-9961(03)00069-x · Cited by 388 · see citing works
Zhao, Y., Jaber, V., & Lukiw, W. J. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00318 · Cited by 379 · see citing works
PARK7, a Novel Locus for Autosomal Recessive Early-Onset Parkinsonism, on Chromosome 1p36
van Duijn, C. M., Dekker, M. C. J., Bonifati, V., Galjaard, R. H., Houwing‐Duistermaat, J. J., Snijders, P. J. L. M., Testers, L., Breedveld, G. J., Horstink, M. W. I. M., Sandkuijl, L. A., et al. (2001) · The American Journal of Human Genetics · doi:10.1086/322996 · Cited by 378 · see citing works
Liu, J., & Wang, F. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01005 · Cited by 376 · see citing works
Hudson, A. J. (1981) · Brain · doi:10.1093/brain/104.2.217 · Cited by 369 · see citing works
Huntington's disease: underlying molecular mechanisms and emerging concepts
Labbadia, J. P., & Morimoto, R. I. (2013) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2013.05.003 · Cited by 368 · see citing works
Gao, H.-M., Zhang, F., Zhou, H., Kam, W., Wilson, B., & Hong, J.-S. (2011) · Environmental Health Perspectives · doi:10.1289/ehp.1003013 · Cited by 355 · see citing works
Zhan, X., Stamova, B. S., & Sharp, F. R. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00042 · Cited by 354 · see citing works
Rate of familial amyotrophic lateral sclerosis: a systematic review and meta-analysis
Byrne, S., Walsh, C., Lynch, C., Bede, P., Elamin, M., Kenna, K. P., McLaughlin, R. L., & Hardiman, O. M. (2010) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2010.224501 · Cited by 351 · see citing works
Chronic neuroinflammation in rats reproduces components of the neurobiology of Alzheimer's disease
Hauss‐Wegrzyniak, B., Dobrzański, P., Stoehr, J. D., & Wenk, G. L. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01215-8 · Cited by 337 · see citing works
UBIQUITIN-IMMUNOREACTIVE INTRANEURONAL INCLUSIONS IN AMYOTROPHIC LATERAL SCLEROSIS
Leigh, P. N., Whitwell, H., Garofalo, O., Buller, J., Swash, M., Martin, J., Gallo, J., Weller, R. O., & Anderton, B. H. (1991) · Brain · doi:10.1093/brain/114.2.775 · Cited by 331 · see citing works
Hunter, R. L., Dragicevic, N., Seifert, K., Choi, D. Y., Liu, M., Kim, H., Cass, W. A., Sullivan, P. G., & Bing, G. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04327.x · Cited by 322 · see citing works
LPS- induced inflammation exacerbates phospho-tau pathology in rTg4510 mice
Lee, D. C., Rizer, J., Selenica, M.-L. B., Reid, P., Kraft, C., Johnson, A., Blair, L., Gordon, M. N., Dickey, C. A., & Morgan, D. (2010) · Journal of Neuroinflammation · doi:10.1186/1742-2094-7-56 · Cited by 293 · see citing works
Role of Microglia TLRs in Neurodegeneration
Fiebich, B. L., Batista, C. R. A., Saliba, S. W., Yousif, N. M., & de Oliveira, A. C. P. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00329 · Cited by 291 · see citing works
Self-citationBachstetter, A. D., Xing, B., de Almeida, L., Dimayuga, E. R., Watterson, D. M., & Van Eldik, L. J. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-79 · Cited by 282 · see citing works
Kanekiyo, T., & Bu, G. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00093 · Cited by 281 · see citing works
Jaeger, L. B., Dohgu, S., Sultana, R., Lynch, J. L., Owen, J. B., Erickson, M. A., Shah, G. N., Price, T. O., Fleegal-Demotta, M. A., Butterfiled, D. A., et al. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2009.01.017 · Cited by 281 · see citing works
Skelly, D., Hennessy, E., Dansereau, M., & Cunningham, C. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069123 · Cited by 278 · see citing works
Qin, L., Liu, Y., Hong, J., & Crews, F. T. (2013) · Glia · doi:10.1002/glia.22479 · Cited by 271 · see citing works
McAlpine, F. E., Lee, J., Harms, A. S., Ruhn, K. A., Blurton-Jones, M. M., Hong, J. J., Das, P., Golde, T. E., LaFerla, F. M., Oddo, S., et al. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.01.006 · Cited by 269 · see citing works
Iravani, M. M., Kashefi, K., Mander, P., Rose, S., & Jenner, P. (2002) · Neuroscience · doi:10.1016/s0306-4522(01)00562-0 · Cited by 247 · see citing works
Hsiao, H., Chen, Y., Chen, H., Tu, P., & Chern, Y. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt036 · Cited by 241 · see citing works
Zughaier, S. M., Zimmer, S. M., Datta, A., Carlson, R. W., & Stephens, D. S. (2005) · Infection and Immunity · doi:10.1128/iai.73.5.2940-2950.2005 · Cited by 240 · see citing works
Castaño, A., Herrera, A. J., Cano, J., & Machado, A. M. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00799.x · Cited by 239 · see citing works
Expression and Regulation of Cyclooxygenase‐2 in Rat Microglia
Bauer, M. K. A., Lieb, K., Schulze‐Osthoff, K., Berger, T., Gebicke‐Haerter, P. J., Bauer, J., & Fiebich, B. L. (1997) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1997.00726.x · Cited by 235 · see citing works
Self-citationQuan, N., Sundar, S. K., & Weiss, J. M. (1994) · Journal of Neuroimmunology · doi:10.1016/0165-5728(94)90188-0 · Cited by 230 · see citing works
Abrogation of α-synuclein–mediated dopaminergic neurodegeneration in LRRK2-deficient rats
Daher, J. P. L., Volpicelli-Daley, L. A., Blackburn, J. P., Moehle, M. S., & West, A. B. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1403215111 · Cited by 223 · see citing works
Dalrymple, A., Wild, E. J., Joubert, R., Sathasivam, K., Björkqvist, M., Petersén, Å., Jackson, G. S., Isaacs, J. D., Kristiansen, M., Bates, G. P., et al. (2007) · Journal of Proteome Research · doi:10.1021/pr0700753 · Cited by 223 · see citing works
Anantharam, V., Kitazawa, M., Wagner, J. R., Kaul, S., & Kanthasamy, A. G. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-05-01738.2002 · Cited by 219 · see citing works
Graves, M. C., Fiala, M., Dinglasan, L. A. V., Liu, N., Sayre, J. W., Chiappelli, F., van Kooten, C., & Vinters, H. V. (2004) · Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders · doi:10.1080/14660820410020286 · Cited by 213 · see citing works
Cazareth, J., Guyon, A., Heurteaux, C., Chabry, J., & Petit-Paitel, A. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-132 · Cited by 206 · see citing works
Distinct neuroinflammatory profile in post-mortem human Huntington's disease
Silvestroni, A., Faull, R. L. M., Strand, A. D., & Möller, T. (2009) · Neuroreport · doi:10.1097/wnr.0b013e32832e34ee · Cited by 204 · see citing works
Gayle, D. A., Ling, Z., Tong, C. W., Landers, T. M., Lipton, J. W., & Carvey, P. M. (2002) · Developmental Brain Research · doi:10.1016/s0165-3806(01)00315-7 · Cited by 201 · see citing works
Inflammatory processes induce beta-amyloid precursor protein changes in mouse brain.
Brugg, B., Lemaigre‐Dubreuil, Y., Huber, G., Wollman, E. E., Delhaye‐Bouchaud, N., & Mariani, J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.7.3032 · Cited by 191 · see citing works
Lipopolysaccharide Animal Models for Parkinson's Disease
Liu, M., & Bing, G. (2011) · Parkinson s Disease · doi:10.4061/2011/327089 · Cited by 191 · see citing works
Glia-dependent neurotoxicity and neuroprotection in mesencephalic cultures
Bronstein, D. M., Pérez‐Otaño, I., Sun, V., Sawin, S. B. M., Chan, J., Wu, G.-C., Hudson, P. M., Kong, L., Hong, J., & McMillian, M. (1995) · Brain Research · doi:10.1016/0006-8993(95)01189-7 · Cited by 186 · see citing works
Ruckdeschel, K., Pfaffinger, G., Haase, R., Sing, A., Weighardt, H., Häcker, G. A., Holzmann, B., & Heesemann, J. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.5.3320 · Cited by 175 · see citing works
Inflammation in Neurological Disorders: A Help or a Hindrance?
Yong, V. W. (2010) · The Neuroscientist · doi:10.1177/1073858410371379 · Cited by 175 · see citing works
Sly, L. M., KRZESICKI, R. F., Brashler, J. R., Buhl, A.-L., McKinley, D. D., Carter, D. B., & Chin, J. E. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00730-4 · Cited by 174 · see citing works
Zhao, Y., Cong, L., Jaber, V. R., & Lukiw, W. J. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01064 · Cited by 170 · see citing works
Minghetti, L., Ajmone‐Cat, M. A., Berardinis, M. A. D., & Simone, R. D. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.12.015 · Cited by 168 · see citing works
Bossù, P., Cutuli, D., Palladino, I., Caporali, P., Angelucci, F., Laricchiuta, D., Gelfo, F., Bartolo, P. D., Caltagirone, C., & Petrosini, L. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-101 · Cited by 168 · see citing works
Lipopolysaccharide-Induced Memory Impairment in Rats: a Model of Alzheimer’s Disease
ZAKARIA, R., WAN YAACOB, W. M. H., OTHMAN, Z., LONG, I., AHMAD, A. H., & AL-RAHBI, B. (2017) · Physiological Research · doi:10.33549/physiolres.933480 · Cited by 167 · see citing works
Kaul, S., Kanthasamy, A., Kitazawa, M., Anantharam, V., & Kanthasamy, A. G. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02864.x · Cited by 165 · see citing works
Chronic Inflammation and Amyloidogenesis in Alzheimer's Disease -- Role of Spirochetes
Miklossy, J. (2008) · Journal of Alzheimer's Disease · doi:10.3233/jad-2008-13404 · Cited by 156 · see citing works
Couch, Y., Alvarez-Erviti, L., Sibson, N. R., Wood, M. J., & Anthony, D. C. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-166 · Cited by 155 · see citing works
Shi, J., Johansson, J. U., Woodling, N. S., Wang, Q., Montine, T. J., & Andreasson, K. I. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903487 · Cited by 155 · see citing works
Time-dependent reduction in Aβ levels after intracranial LPS administration in APP transgenic mice
Herber, D. L., Roth, L. M., Wilson, D. H., Wilson, N., Mason, J. E., Morgan, D., & Gordon, M. N. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.07.007 · Cited by 147 · see citing works
Polyglutamine Diseases and Transport Problems
Gunawardena, S., & Goldstein, L. S. B. (2005) · Archives of Neurology · doi:10.1001/archneur.62.1.46 · Cited by 145 · see citing works
Erickson, M. A., Hartvigson, P. E., Morofuji, Y., Owen, J. B., Butterfield, D. A., & Banks, W. A. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-150 · Cited by 145 · see citing works
Leow‐Dyke, S., Allen, C., Dénes, Á., Nilsson, O., Maysami, S., Bowie, A., Rothwell, N. J., & Pinteaux, E. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-230 · Cited by 145 · see citing works
Akundi, R. S., Candelario‐Jalil, E., Hess, S., Hüll, M., Lieb, K., Gebicke‐Haerter, P. J., & Fiebich, B. L. (2005) · Glia · doi:10.1002/glia.20198 · Cited by 141 · see citing works
Self-citationStriatal Neuroinflammation Promotes Parkinsonism in Rats
Choi, D.-Y., Liu, M., Hunter, R. L., Cass, W. A., Pandya, J. D., Sullivan, P. G., Shin, E.-J., Kim, H.-C., Gash, D. M., & Bing, G. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005482 · Cited by 141 · see citing works
Herber, D. L., Mercer, M., Roth, L. M., Symmonds, K., Maloney, J. L., Wilson, N., Freeman, M. J., Morgan, D., & Gordon, M. N. (2007) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-007-9069-z · Cited by 138 · see citing works
Exposure to bacterial endotoxin generates a distinct strain of α-synuclein fibril
Kim, C., Lv, G., Lee, J. S., Jung, B. C., Masuda-Suzukake, M., Hong, C.-S., Valera, E., Lee, H.-J., Paik, S. R., Hasegawa, M., et al. (2016) · Scientific Reports · doi:10.1038/srep30891 · Cited by 138 · see citing works
Zhang, D., Anantharam, V., Kanthasamy, A., & Kanthasamy, A. G. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.124669 · Cited by 137 · see citing works
Fiebich, B. L., Schleicher, S., Butcher, R. D., et al. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.10.5606 · Cited by 133 · see citing works
Self-citationBouchard, J. J., Truong, J. K., Bouchard, K. E., Dunkelberger, D. L., Desrayaud, S., Moussaoui, S. M., Tabrizi, S. J., Stella, N., & Muchowski, P. J. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.4008-12.2012 · Cited by 133 · see citing works
Dewil, M., dela Cruz, V. F., Van Den Bosch, L., & Robberecht, W. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.12.023 · Cited by 133 · see citing works
Bacteroidetes Neurotoxins and Inflammatory Neurodegeneration
Zhao, Y., & Lukiw, W. J. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1015-y · Cited by 129 · see citing works
Toll-Like Receptors and Inflammation in the CNS
Lee, B. S. P. S. J., & Lee, B. S. P. S. (2002) · Current Drug Targets - Inflammation & Allergy · doi:10.2174/1568010023344698 · Cited by 127 · see citing works
Alpizar, Y. A., Boonen, B., Sánchez, A., Jung, C., López‐Requena, A., Naert, R., Steelant, B., Luyts, K., Plata, C., Vooght, V. D., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01201-3 · Cited by 126 · see citing works
Franciosi, S., Ryu, J. K., Shim, Y. A., Hill, A. M., Connolly, C., Hayden, M. R., McLarnon, J. G., & Leavitt, B. R. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.09.003 · Cited by 124 · see citing works
Iravani, M. M., Leung, C. C. M., Sadeghian, M., Haddon, C. O., Rose, S., & Jenner, P. G. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04220.x · Cited by 123 · see citing works
Arai, H., Furuya, T., Yasuda, T., Miura, M., Mizuno, Y., & Mochizuki, H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407328200 · Cited by 122 · see citing works
Genetic Forms of Parkinson's Disease
Kim, C., & Alcalay, R. N. (2017) · Seminars in Neurology · doi:10.1055/s-0037-1601567 · Cited by 120 · see citing works
Inflammation Induces TDP-43 Mislocalization and Aggregation
Correia, A. S., Patel, P., Dutta, K., & Julien, J.-P. (2015) · PLOS ONE · doi:10.1371/journal.pone.0140248 · Cited by 114 · see citing works
Diverse microglial responses after intrahippocampal administration of lipopolysaccharide
Herber, D. L., Maloney, J. L., Roth, L. M., Freeman, M. J., Morgan, D., & Gordon, M. N. (2005) · Glia · doi:10.1002/glia.20272 · Cited by 114 · see citing works
François, A., Terro, F., Janet, T., Bilan, A. R., Paccalin, M., & Page, G. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-151 · Cited by 110 · see citing works
Gordon, R., Singh, N., Lawana, V., Ghosh, A., Harischandra, D. S., Jin, H., Hogan, C., Sarkar, S., Rokad, D., Panicker, N., et al. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.04.008 · Cited by 105 · see citing works
Hoozemans, J. J. M., Veerhuis, R., Janssen, I., van Elk, E.-J., Rozemüller, A. J. M., & Eikelenboom, P. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03164-5 · Cited by 104 · see citing works
Erickson, M. A., Hansen, K. M., & Banks, W. A. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.07.003 · Cited by 100 · see citing works
Intrastriatal lipopolysaccharide injection induces parkinsonism in C57/B6 mice
Hunter, R. L., Cheng, B., Choi, D., Liu, M., Liu, S., Cass, W. A., & Bing, G. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22012 · Cited by 100 · see citing works
Bacterial lipopolysaccharide regulates nociceptin expression in sensory neurons
Acosta, C. G., & Davies, A. M. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21565 · Cited by 100 · see citing works
Fiebich, B. L., Lieb, K., Engels, S., & Heinrich, M. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(02)00279-5 · Cited by 96 · see citing works
Self-citationZhang, F., Li, Q., Flood, P. M., Shi, J., Hong, J., & Gao, H. (2010) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.165829 · Cited by 92 · see citing works
Mangano, E. N., & Hayley, S. P. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.11.020 · Cited by 91 · see citing works
Differential effects of lipopolysaccharide on mouse sensory TRP channels
Boonen, B., Alpizar, Y. A., Sánchez, A., López‐Requena, A., Voets, T., & Talavera, K. (2018) · Cell Calcium · doi:10.1016/j.ceca.2018.04.004 · Cited by 91 · see citing works
Lu, X., Bing, G., & Hagg, T. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00033-6 · Cited by 89 · see citing works
McMillian, M. K., Kong, L. Y., Sawin, S., et al. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2503 · Cited by 88 · see citing works
Inflammation, Immunity, and amyotrophic lateral sclerosis: I. Etiology and pathology
Lyon, M. S., Wosiski‐Kuhn, M., Gillespie, R., Caress, J. B., & Milligan, C. (2018) · Muscle & Nerve · doi:10.1002/mus.26289 · Cited by 88 · see citing works
Go, M., Kou, J., Lim, J.-E., Yang, J., & Fukuchi, K.-I. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.09.073 · Cited by 87 · see citing works
Endotoxin induces a delayed loss of TH-IR neurons in substantia nigra and motor behavioral deficits
Liu, Y., Qin, L., Wilson, B., Wu, X., Qian, L., Granholm, A.-C., Crews, F. T., & Hong, J.-S. (2008) · NeuroToxicology · doi:10.1016/j.neuro.2008.02.014 · Cited by 84 · see citing works
Mattson, M. P., Lee, J., & Chan, S. L. (2002) · NeuroMolecular Medicine · doi:10.1385/nmm:2:1:29 · Cited by 83 · see citing works
Burguillos, M. Á., Hajji, N., Englund, E. M., Persson, A., Cenci, M. A., Machado, A., Cano, J., Joseph, B., & Venero, J. L. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.09.005 · Cited by 82 · see citing works
Molecular Mechanisms Regulating LPS-Induced Inflammation in the Brain
Lykhmus, O., Mishra, N., Koval, L., Kalashnyk, O., Gergalova, G., Uspenska, K., Комісаренко, С. В., Soreq, H., & Skok, M. (2016) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2016.00019 · Cited by 79 · see citing works
Philippens, I. H. C. H. M., Ormel, P. R., Baarends, G., Johansson, M., Remarque, E. J., & Doverskog, M. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160673 · Cited by 79 · see citing works
Skelly, D. T., Hennessy, E., Dansereau, M.-A., & Cunningham, C. (2013) · PLoS ONE · doi:10.1371/annotation/90c76048-2edd-4315-8404-4d9d8cbd411e · Cited by 77 · see citing works
Jangula, A., & Murphy, E. J. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.06.058 · Cited by 76 · see citing works
Beier, E. E., Neal, M. P., Alam, G., Edler, M. K., Wu, L., & Richardson, J. R. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.08.009 · Cited by 76 · see citing works
Deng, X., Li, M., Ai, W., He, L., Lu, D., Patrylo, P. R., Cai, H., Luo, X., Li, Z., & Yan, X. (2014) · Advances in Alzheimer s Disease · doi:10.4236/aad.2014.32009 · Cited by 75 · see citing works
Protective properties afforded by pioglitazone against intrastriatal LPS in Sprague–Dawley rats
Hunter, R. L., Choi, D., Ross, S. A., & Bing, G. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.12.019 · Cited by 74 · see citing works
Role of nitric oxide in the brain during lipopolysaccharide‐evoked systemic inflammation
Czapski, G. A., Cąkała, M., Chalimoniuk, M., Gajkowska, B., & Strosznajder, J. B. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21294 · Cited by 74 · see citing works
Lipopolysaccharide endotoxemia induces amyloid-β and p-tau formation in the rat brain.
Wang, L., Wu, Q., Kirk, R. A., Horn, K. P., Salem, A. E., Hoffman, J. M., Yap, J. T., Sonnen, J. A., Towner, R. A., Bozza, F. A., et al. (2018) · Europe PMC (PubMed Central) · Cited by 73 · see citing works
Katafuchi, T., Ifuku, M., Mawatari, S., Noda, M., Miake, K., Sugiyama, M., & Fujino, T. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06641.x · Cited by 68 · see citing works
Marottoli, F. M., Katsumata, Y., Koster, K. P., Thomas, R., Fardo, D. W., & Tai, L. M. (2017) · ASN NEURO · doi:10.1177/1759091417719201 · Cited by 68 · see citing works
Zhang, J., Stanton, D. M., Nguyen, X. V., Liu, M., Zhang, Z., Gash, D. M., & Bing, G. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.06.049 · Cited by 64 · see citing works
Madera-Salcedo, I. K., Cruz, S. L., & González‐Espinosa, C. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202658 · Cited by 63 · see citing works
Chien, C.-H., Lee, M., Liou, H., Liou, H., & Fu, W. (2016) · PLoS ONE · doi:10.1371/journal.pone.0151569 · Cited by 63 · see citing works
Jeohn, G., Cooper, C. L., Wilson, B. C., Chang, R. C., Jang, K., Kim, H.-C., Liu, B., & Hong, J. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04078.x · Cited by 60 · see citing works
Ma, L., Zhang, H., Liu, N., Wang, P.-Q., Guo, W.-Z., Fu, Q., Jiao, L.-B., Ma, Y.-Q., & Mi, W. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.02.001 · Cited by 60 · see citing works
Loss of Striatal Neurons in Parkinson’s Disease: a Cytometric Study
Bugiani, O., Perdelli, F., Salvarani, S., LEONARDI, A., & Mancardi, G. (2008) · European Neurology · doi:10.1159/000115172 · Cited by 59 · see citing works
Behairi, N., Belkhelfa, M., Rafa, H., Labsi, M., Deghbar, N., Bouzid, N., Mesbah-Amroun, H., & Touil–Boukoffa, C. (2016) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2016.10.004 · Cited by 59 · see citing works
Toll-like Receptors, LPS, and Dental Monomers
Schmalz, G., Krifka, S., & Schweikl, H. (2011) · Advances in Dental Research · doi:10.1177/0022034511405391 · Cited by 57 · see citing works
Fiebich, B. L., Butcher, R. D., & Gebicke-Haerter, P. J. (1998) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(98)00201-x · Cited by 57 · see citing works
Self-citationLykhmus, O., Voytenko, L. P., Koval, L., Mykhalskiy, S., Kholin, V. A., Peschana, K., Zouridakis, M., Tzartos, S. J., Комісаренко, С. В., & Skok, M. V. (2015) · PLoS ONE · doi:10.1371/journal.pone.0122706 · Cited by 57 · see citing works
Ma, B., Xu, L., Pan, X., Sun, L., Ding, J., Xie, C., Koliatsos, V. E., & Cai, H. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw194 · Cited by 57 · see citing works
Xu, W., Zheng, D., Liu, Y., Li, J., Yang, L., & Shang, X. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000485947 · Cited by 57 · see citing works
Blood-Brain Barrier Integrity and Clearance of Amyloid-β from the BBB
Cockerill, I., Oliver, J.-A. N., Xu, H., Fu, B. M., & Zhu, D. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-96445-4_14 · Cited by 56 · see citing works
The Parkinson's disease-related genes act in mitochondrial homeostasis
Sai, Y., Zou, Z., Peng, K., & Dong, Z. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.06.007 · Cited by 55 · see citing works
Zhu, Y., Chen, X., Liu, Z., Peng, Y.-P., & Qiu, Y. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms17010025 · Cited by 55 · see citing works
Bardou, I., Kaercher, R. M., Brothers, H. M., Hopp, S. C., Royer, S. E., & Wenk, G. L. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.11.006 · Cited by 54 · see citing works
Malm, T., Magga, J. M., Kuh, G. F., Vatanen, T., Koistinaho, M., & Koıstınaho, J. (2008) · Glia · doi:10.1002/glia.20726 · Cited by 53 · see citing works
Flores-Martinez, Y. M., Fernandez-Parrilla, M. A., Ayala-Dávila, J., Reyes-Corona, D., Blanco-Álvarez, V. M., Soto-Rojas, L. O., Luna-Herrera, C., González-Barrios, J. A., León‐Chávez, B. A., Gutiérrez-Castillo, M. E., et al. (2018) · Journal of Immunology Research · doi:10.1155/2018/1838921 · Cited by 53 · see citing works
Ruano, D., Revilla, E., Gavilán, M. P., Vizuete, M., Pintado, C., Vitórica, J., & Castaño, A. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.02.073 · Cited by 49 · see citing works
Synucleinopathies: common features and hippocampal manifestations
Yang, W., & Yu, S. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2411-y · Cited by 49 · see citing works
Huang, Y., Zhang, Q., Zhang, J.-N., Zhang, Y., Gu, L., Yang, H.-M., Xia, N., Wang, X., & Zhang, H. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.04.006 · Cited by 49 · see citing works
Lipopolysaccharide Induced Opening of the Blood Brain Barrier on Aging 5XFAD Mouse Model
Barton, S. M., Janve, V. A., McClure, R., Anderson, A. W., Matsubara, J. A., Gore, J. C., & Pham, W. N. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180755 · Cited by 49 · see citing works
Human apoE3 but not apoE4 rescues impaired astrocyte activation in apoE null mice
Ophir, G., Meilin, S., Efrati, M., Chapman, J., Karussis, D., Roses, A. D., & Michaelson, D. M. (2003) · Neurobiology of Disease · doi:10.1016/s0969-9961(02)00005-0 · Cited by 48 · see citing works
Sharma, N., & Nehru, B. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9267-2 · Cited by 47 · see citing works
Bhatia, H. S., Roelofs, N., Muñóz, E., & Fiebich, B. L. (2017) · Scientific Reports · doi:10.1038/s41598-017-00225-5 · Cited by 46 · see citing works
Self-citationRoe, A. D., Staup, M. A., Serrats, J., Sawchenko, P. E., & Rissman, R. A. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07764.x · Cited by 45 · see citing works
Zheng, H.-F., Yang, Y., Hu, L., Wang, M., Wang, F., Cao, L.-D., Li, D., Mao, C., Xiong, K., Wang, J.-D., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070472 · Cited by 43 · see citing works
Thygesen, C., Ilkjær, L., Kempf, S. J., Hemdrup, A. L., von Linstow, C. U., Babcock, A. A., Darvesh, S., Larsen, M. R., & Finsen, B. R. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00397 · Cited by 43 · see citing works
Hunter, R. L., Ojha, U., Bhurtel, S., Bing, G., & Choi, D. (2016) · Neuroscience Research · doi:10.1016/j.neures.2016.09.007 · Cited by 42 · see citing works
Turner, R. C., Naser, Z. J., Lucke-Wold, B. P., Logsdon, A. F., VanGilder, R. L., Matsumoto, R. R., Huber, J. D., & Rosen, C. L. (2017) · Neuroimmunology and Neuroinflammation · doi:10.20517/2347-8659.2016.40 · Cited by 40 · see citing works
Yousif, N. M., de Oliveira, A. C. P., Brioschi, S., Hüell, M., Biber, K. P. H., & Fiebich, B. L. (2017) · Glia · doi:10.1002/glia.23276 · Cited by 39 · see citing works
Self-citationL’Episcopo, F., Tirolo, C., Testa, N., Caniglia, S., Morale, M. C., Impagnatiello, F., & Marchetti, B. (2011) · Rejuvenation Research · doi:10.1089/rej.2010.1134 · Cited by 38 · see citing works
Ohgomori, T., Yamada, J., Takeuchi, H., Kadomatsu, K., & Jinno, S. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13227 · Cited by 38 · see citing works
Huntington's disease: Molecular basis of pathology and status of current therapeutic approaches
Huang, W., Chen, W., & Zhang, X. (2016) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2016.3566 · Cited by 37 · see citing works
Zhang, W., Gao, J.-H., Yan, Z.-F., Huang, X.-Y., Guo, P., Sun, L., Liu, Z., Hu, Y., Zuo, L.-J., Yu, S.-Y., et al. (2018) · Molecular Neurobiology · doi:10.1007/s12035-016-0308-2 · Cited by 37 · see citing works
CCAAT/enhancer binding protein δ regulates glial proinflammatory gene expression.
Valente, T., Straccia, M., Gresa-arribas, N., Dentesano, G., Tusell, J. M., Serratosa, J., Mancera, P., Solà, C., & Saura, J. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.02.007 · Cited by 35 · see citing works
Maher, A., Sayed, N. S. E., Breitinger, H., & Gad, M. Z. (2014) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2014.10.007 · Cited by 35 · see citing works
Sharma, N., Sharma, S., & Nehru, B. (2017) · Inflammopharmacology · doi:10.1007/s10787-017-0346-z · Cited by 35 · see citing works
The Synergy of Aging and LPS Exposure in a Mouse Model of Parkinson’s Disease
Zhao, Y., Qiong-Zhang, Zhang, J., Lou, Z., Zu, H.-B., Wang, Z., Wei-cheng, Z., Kai-Yao, & Xiao, B. (2018) · Aging and Disease · doi:10.14336/ad.2017.1028 · Cited by 35 · see citing works
Gu, C., Hu, Q., Wu, J., Mu, C., Ren, H., Liu, C., & Wang, G. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00400 · Cited by 34 · see citing works
Microglia activation mediated by toll-like receptor-4 impairs brain white matter tracts in rats
Xinglong, Y., Zhang, J., Duan, L., Huangui, X., Yanping, J., & Houcheng, L. (2018) · Journal of Biomedical Research · doi:10.7555/jbr.32.20170033 · Cited by 31 · see citing works
Amyotrophic Lateral Sclerosis: Current Understanding
Charles, T., & Swash, M. (2001) · Journal of Neuroscience Nursing · doi:10.1097/01376517-200110000-00005 · Cited by 30 · see citing works
Gray, P., Dagvadorj, J., Michelsen, K. S., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100890 · Cited by 30 · see citing works
Chistyakov, D. V., Azbukina, N. V., Lopachev, A. V., Куличенкова, К. Н., Astakhova, A. A., & Sergeeva, M. G. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19010113 · Cited by 30 · see citing works
Sharma, N., Kapoor, M., & Nehru, B. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.09.012 · Cited by 28 · see citing works
The psychopathology of Huntington's disease.
Se, F. (1991) · PubMed · Cited by 27 · see citing works
Impairment of long-term depression induced by chronic brain inflammation in rats
Min, S. S., Quan, H. Y., Ma, J., et al. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.03.133 · Cited by 19 · see citing works
Zhang, K. (2011) · Molecular Medicine Reports · doi:10.3892/mmr.2011.671 · Cited by 19 · see citing works
The role of the TLR4/NF-κB signaling pathway in Aβ accumulation in primary hippocampal neurons.
Wu, D., Zhang, X., Zhao, M., & Zhou, A. (2015) · PubMed · Cited by 19 · see citing works
Wang, D., Liu, Y., Zhao, Y., et al. (2016) · Chinese Journal of Traumatology · doi:10.1016/j.cjtee.2016.06.001 · Cited by 15 · see citing works
Common variation in the LRRK2 gene is a risk factor for Parkinson's disease
Mata, I. F., Checkoway, H., Hutter, C. M., et al. (2012) · Movement Disorders · doi:10.1002/mds.25226 · Cited by 14 · see citing works
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The endotoxin hypothesis of neurodegeneration
Brown, G. C. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1564-7 · Cited by 457 · see citing works
Molecular and spatial signatures of mouse brain aging at single-cell resolution
Allen, W. E., Blosser, T. R., Sullivan, Z. A., Dulac, C., & Zhuang, X. (2023) · Cell · doi:10.1016/j.cell.2022.12.010 · Cited by 423 · see citing works
“46 Although LPS itself is thought not to cross the blood-brain barrier, systemic release of cytokines and chemokines by peripheral immune cells upon LPS administration can broadly activate microglia and astrocytes throughout the brain.”
Exercise plasma boosts memory and dampens brain inflammation via clusterin
De Miguel, Z., Khoury, N., Betley, M. J., Lehallier, B., Willoughby, D., Olsson, N., Yang, A. C., Hahn, O., Lu, N., Vest, R. T., et al. (2021) · Nature · doi:10.1038/s41586-021-04183-x · Cited by 422 · see citing works
TLR4 Cross-Talk With NLRP3 Inflammasome and Complement Signaling Pathways in Alzheimer's Disease
Yang, J., Wise, L., & Fukuchi, K.-I. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00724 · Cited by 387 · see citing works
The role of lipopolysaccharide-induced cell signalling in chronic inflammation
Page, M. J., Kell, D. B., & Pretorius, E. (2022) · Chronic Stress · doi:10.1177/24705470221076390 · Cited by 315 · see citing works
An overall view of the most common experimental models for multiple sclerosis
Dedoni, S., Scherma, M., Camoglio, C., Siddi, C., Dazzi, L., Puliga, R., Frau, J., Cocco, E., & Fadda, P. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106230 · Cited by 79 · see citing works
Niu, H., Wang, Q., Zhao, W., Liu, J., Wang, D., Muhammad, B., Liu, X., Quan, N., Zhang, H., Zhang, F., et al. (2020) · Brain Pathology · doi:10.1111/bpa.12886 · Cited by 62 · see citing works
Hafiz, Z. Z., Amin, M. ‘. M., Johari James, R. M., Teh, L. K., Salleh, M. Z., & Adenan, M. I. (2020) · Molecules · doi:10.3390/molecules25040892 · Cited by 64 · see citing works
Gut microbiota as a potential player in mn-induced neurotoxicity
Tinkov, A. A., Martins, A. C., Avila, D. S., Gritsenko, V. A., Skalny, A. V., Santamaria, A., Lee, E., Bowman, A. B., & Aschner, M. (2021) · Biomolecules · doi:10.3390/biom11091292 · Cited by 45 · see citing works
Andreadou, E. G., Katsipis, G., Tsolaki, M., & Pantazaki, A. A. (2021) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2021.577561 · Cited by 31 · see citing works
In Situ Detection of Neuroinflammation Using Multicellular 3D Neurovascular‐Unit‐on‐a‐Chip
Choi, J., Choi, H. K., & Lee, K. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202304382 · Cited by 21 · see citing works
Johnston, J. L., Reda, S. M., Setti, S. E., Taylor, R. W., Berthiaume, A.-A., Walker, W. E., Wu, W., Moebius, H. J., & Church, K. J. (2023) · Neurotherapeutics · doi:10.1007/s13311-022-01325-5 · Cited by 18 · see citing works
Mizobuchi, H. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1110583 · Cited by 11 · see citing works
- Authors
- Batista, C. R. A., Gomes, G. F., Candelario-Jalil, E., Fiebich, B. L., & de Oliveira, A. C. P.
- Affiliations
- Department of Pharmacology, Universidade Federal de Minas Gerais, Av. Antonio Carlos 6627, Belo Horizonte 31270-901, Brazil
- Universidade Federal de Minas Gerais (BR)
- Department of Neuroscience, University of Florida, Gainesville, FL 32610, USA
- University of Freiburg (DE)
- Corresponding author
- Fiebich, Bernd L.
- ORCID
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2019-05-09
- Volume
- 20
- Issue
- 9
- Pages
- 2293
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC6539529
- OpenAlex
- W2944532057
- Cited by
- 529
- References
- 204
- Citations by year
- 2026: 55 · 2025: 69 · 2024: 109 · 2023: 100 · 2022: 90 · 2021: 56 · 2020: 42 · 2019: 8
- FWCI
- 5.10
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq - 424588/2016-1, CNPq - 309718/2015-5)
- Fundação de Amparo à Pesquisa do Estado de Minas Gerais (CBB-APQ-02044-15)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Keywords
- lipopolysaccharide, neuroinflammation, neurodegeneration, neurodegenerative disease models, inflammatory mediators, route of administration
- MeSH terms
- Animals, Disease Models, Animal, Humans, Inflammation, Lipopolysaccharides, Nerve Degeneration, Nervous System, Neurodegenerative Diseases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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