The DOI matches its Crossref record.
Neuroleptic malignant syndrome: A pathogenetic role for dopamine receptor blockade?
Abstract
The neuroleptic malignant syndrome (NMS) of extrapyramidal signs and hyperthermia is an uncommon complication of therapy with the major tranquilizers. Other manifestations are pallor, diaphoresis, blood pressure fluctuation, tachycardia, and tachypneic hypoventilation, which may necessitate respirator support. Death often occurs, but full recovery can result with prompt recognition and proper management. In a patient with Parkinson disease and a chronic psychiatric disorder treated with haloperidol, typical features of NMS appeared upon cessation of dopaminergic antiparkinsonian drugs. Manifestations of NMS are attributed to dopamine receptor blockade in the striatum, increasing thermogenesis, and in the hypothalamus, impairing heat dissipation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Neuroleptic Malignant Syndrome
Guzé, B. H., & Baxter, L. R. (1985) · New England Journal of Medicine · doi:10.1056/nejm198507183130306 · Cited by 312
Neuroleptic Malignant Syndrome: A Review from a Clinically Oriented Perspective
Tse, L., Barr, A., Scarapicchia, V., & Vila-Rodriguez, F. (2015) · Current Neuropharmacology · doi:10.2174/1570159x13999150424113345 · Cited by 179
Neuroleptic malignant syndrome after neuroleptic discontinuation
Amore, M., & Zazzeri, N. (1995) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(95)00269-3 · Cited by 42
A Hyperthermic Syndrome in Two Subjects With Acute Hydrocephalus
Talman, W. T., Florek, G., & Bullard, D. E. (1988) · Archives of Neurology · doi:10.1001/archneur.1988.00520330129022 · Cited by 38
Metadata
- Authors
- Henderson, V. W., & Wooten, G. F.
- Venue
- Neurology
- Published
- 1981-02
- Volume
- 31
- Issue
- 2
- Pages
- 132-132
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2055071717
- Cited by
- 339
- References
- 0
- FWCI
- 15.44
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Neuroleptic malignant syndrome: A pathogenetic role for dopamine receptor blockade? https://app.cochat.ai/papers/10.1212/wnl.31.2.132
- The paper
- Henderson, V. W., & Wooten, G. F. (1981). Neuroleptic malignant syndrome: A pathogenetic role for dopamine receptor blockade? Neurology. https://doi.org/10.1212/wnl.31.2.132
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
