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Cited by 42Electroconvulsive Therapy StudiesSchizophrenia research and treatmentHistorical Psychiatry and Medical Practices

Neuroleptic malignant syndrome after neuroleptic discontinuation

Amore, Mario, Zazzeri, Nicoletta·1995·Progress in Neuro-Psychopharmacology and Biological Psychiatry
DOI 10.1016/0278-5846(95)00269-3
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Abstract

1. Neuroleptic withdrawal can cause autonomic and behavioral symptoms (nausea, vomiting, diarrhea, diaphoresis, myalgia, anxiety, restlessness) and movement disorders (withdrawal emergent parkinsonism, withdrawal dyskinesia, covert dyskinesia). 2. Neuroleptic malignant syndrome (NMS) is a rare but extremely severe adverse reaction to neuroleptic drugs characterized by extrapyramidal and autonomic symptoms, altered level of consciousness and abnormal laboratory findings. 3. Withdrawal neuroleptic malignant syndrome, though an even rarer condition (only 7 cases reported to date), should alert to consider the possibility that abrupt neuroleptic discontinuation can be complicated by NMS. 4. The pathophysiology of withdrawal medical symptoms may be related to a cholinergic rebound; withdrawal neuroleptic malignant syndrome may be attributed to an "imbalance" in the dopaminergic system. 5. The authors report two cases of NMS precipitated by the abrupt withdrawal of neuroleptic drugs.

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Authors
Amore, M., & Zazzeri, N.
Affiliations
University of Bologna (IT)
Corresponding author
Amore, Mario
ORCID
Amore, Mario
Venue
Progress in Neuro-Psychopharmacology and Biological Psychiatry
Publisher
Elsevier BV
Published
1995-12
Volume
19
Issue
8
Pages
1323-1334
ISSN
0278-5846 (ISSN-L)
DOI
10.1016/0278-5846(95)00269-3
OpenAlex
W1975684767
Cited by
42
References
43
Citations by year
2025: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 4 · 2020: 1 · 2019: 3 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 3 · 2012: 2
FWCI
0.31
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Social Sciences › Psychology › Clinical Psychology › Historical Psychiatry and Medical Practices
Keywords
neuroleptic malignant syndrome, neuroleptic withdrawal, adverse drug reactions, extrapyramidal symptoms, autonomic symptoms
MeSH terms
Autonomic Nervous System Diseases, Dyskinesia, Drug-Induced, Female, Humans, Male, Middle Aged, Neuroleptic Malignant Syndrome, Psychotic Disorders, Schizophrenia, Paranoid, Schizophrenic Psychology, Substance Withdrawal Syndrome, Antipsychotic Agents

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