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Multifocal demyelinating neuropathy with persistent conduction block
Abstract
We describe five patients with a chronic asymmetric sensorimotor neuropathy most pronounced in the upper extremities with focal involvement of individual nerves. Diagnosis was established by electrophysiologic evidence of persistent multifocal conduction block. Sural nerve biopsy in three patients showed primarily demyelinating-remyelinating changes with varying degrees of fiber loss. Two patients had acute optic neuritis, indicating that the disorder was not always restricted to the peripheral nervous system. Two patients treated with corticosteroids improved, whereas three untreated patients had static deficits or steady progression of symptoms. Chronic multifocal demyelinating neuropathy with persistent conduction block seems to be a variant of chronic acquired demyelinating polyneuropathy and may be immunologically mediated.
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Citations
Cited by
Peripheral neuropathies and anti-glycolipid antibodies
Willison, H. J. (2002) · Brain · doi:10.1093/brain/awf272 · Cited by 710
Clinical spectrum of chronic acquired demyelinating polyneuropathies
Saperstein, D. S., Katz, J. S., Amato, A. A., & Barohn, R. J. (2001) · Muscle & Nerve · doi:10.1002/1097-4598(200103)24:3<311::aid-mus1001>3.0.co;2-a · Cited by 417
Gorson, K. C., Allam, G., & Ropper, A. H. (1997) · Neurology · doi:10.1212/wnl.48.2.321 · Cited by 329
Differential expression of cytokines in painful and painless neuropathies
Üçeyler, N., Rogausch, J. P., Toyka, K. V., & Sommer, C. (2007) · Neurology · doi:10.1212/01.wnl.0000265062.92340.a5 · Cited by 316
Aberrant microRNA expression in patients with painful peripheral neuropathies
Leinders, M., Üçeyler, N., Thomann, A., & Sommer, C. (2017) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2017.07.041 · Cited by 57
Metadata
- Authors
- Lewis, R. A., Sumner, A. J., Brown, M. J., & Asbury, A. K.
- Venue
- Neurology
- Published
- 1982-09
- Volume
- 32
- Issue
- 9
- Pages
- 958-958
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2014464814
- Cited by
- 502
- References
- 0
- FWCI
- 2.13
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lewis, R. A., Sumner, A. J., Brown, M. J., & Asbury, A. K. (1982). Multifocal demyelinating neuropathy with persistent conduction block. Neurology. https://doi.org/10.1212/wnl.32.9.958
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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