Cited by 57Pain Mechanisms and TreatmentsPeripheral Neuropathies and DisordersMicroRNA in disease regulation

Aberrant microRNA expression in patients with painful peripheral neuropathies

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Leinders, Mathias, Üçeyler, Nurcan, Thomann, Anna, Sommer, Claudia·2017·Journal of the Neurological Sciences

Abstract

Changes in the neuro-immune balance play a major role in the induction and maintenance of neuropathic pain. We recently reported pathophysiologically relevant alterations in skin and sural nerve cytokine expression in peripheral neuropathies of different etiologies. Immune processes and cytokine expression are under tight control of microRNAs (miRNAs). To identify potential master switches in the neuro-immune balance, we aimed at characterizing inflammation-regulating miRNA profiles in patients with peripheral neuropathies. In an unselected patient cohort with polyneuropathies of different etiologies seen at our neuromuscular center between 2014 and 2015, we determined the systemic and local relative expression of miR-21-5p, miR-146a, and miR-155. In white blood cells we found higher miR-21 (p<0.001) and miR-146a (p<0.001) expression and lower miR-155 (p<0.001) expression when compared to healthy controls. In sural nerve, miR-21 (p<0.02) was increased in painful compared to painless neuropathies. In painful neuropathies, skin biopsies from the lower leg had reduced miR-146a (p<0.001) and miR-155 (p<0.001) expression compared to the thigh. Thus, peripheral neuropathies are associated with aberrant miRNA expression in white blood cells, sural nerve, and skin. These miRNA patterns may help to identify factors that determine the painfulness of peripheral neuropathies and lead to druggable targets.

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Crossref · 10.1016/j.jns.2017.07.041

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Authors
Leinders, M., Üçeyler, N., Thomann, A., & Sommer, C.
Affiliations
University of Würzburg (DE)
Corresponding author
Leinders, Mathias
Venue
Journal of the Neurological Sciences
Publisher
Elsevier BV
Published
2017-09
Volume
380
Pages
242-249
ISSN
0022-510X (ISSN-L)
OpenAlex
W2741097995
Cited by
57
References
82
Citations by year
2026: 2 · 2025: 6 · 2024: 5 · 2023: 9 · 2022: 10 · 2021: 8 · 2020: 7 · 2019: 5 · 2018: 4 · 2017: 1
FWCI
3.45
Type
journal article
Language
en
Open access
Locations
  • Journal of the Neurological Sciences (publishedVersion)
  • PubMed (publishedVersion)
  • Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
Funders
  • Deutsche Forschungsgemeinschaft
  • Seventh Framework Programme (602133)
  • Julius-Maximilians-Universität Würzburg
Topics
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
  • Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Keywords
microRNA expression, peripheral neuropathy, neuropathic pain, miR-21, miR-146a, miR-155, leukocytes, sural nerve, skin biopsy, inflammation, polyneuropathy
MeSH terms
Adult, Aged, Aged, 80 and over, Biopsy, Female, Gene Expression Regulation, Humans, Male, Middle Aged, Pain, Pain Measurement, Peripheral Nervous System Diseases, Severity of Illness Index, Sural Nerve, Cohort Studies, Cytokines, Statistics, Nonparametric, MicroRNAs

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