Aberrant microRNA expression in patients with painful peripheral neuropathies
Open accessAbstract
Changes in the neuro-immune balance play a major role in the induction and maintenance of neuropathic pain. We recently reported pathophysiologically relevant alterations in skin and sural nerve cytokine expression in peripheral neuropathies of different etiologies. Immune processes and cytokine expression are under tight control of microRNAs (miRNAs). To identify potential master switches in the neuro-immune balance, we aimed at characterizing inflammation-regulating miRNA profiles in patients with peripheral neuropathies. In an unselected patient cohort with polyneuropathies of different etiologies seen at our neuromuscular center between 2014 and 2015, we determined the systemic and local relative expression of miR-21-5p, miR-146a, and miR-155. In white blood cells we found higher miR-21 (p<0.001) and miR-146a (p<0.001) expression and lower miR-155 (p<0.001) expression when compared to healthy controls. In sural nerve, miR-21 (p<0.02) was increased in painful compared to painless neuropathies. In painful neuropathies, skin biopsies from the lower leg had reduced miR-146a (p<0.001) and miR-155 (p<0.001) expression compared to the thigh. Thus, peripheral neuropathies are associated with aberrant miRNA expression in white blood cells, sural nerve, and skin. These miRNA patterns may help to identify factors that determine the painfulness of peripheral neuropathies and lead to druggable targets.
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Aberrant miRNA expression has been reported in cancer, musculoskeletal disorders, painful peripheral neuropathies, and fibromyalgia.
“Aberrant miRNA expression has been reported in several pathological conditions including cancer, musculoskeletal disorders, painful peripheral neuropathies, and fibromyalgia [164,165,166].”
From Cellular and Molecular Mechanisms in the Pathogenesis of Classical, Vascular, and Hypermobile Ehlers‒Danlos Syndromes (2019) · cites this paper as [164]
Cites
Taganov, K. D., Boldin, M. P., Chang, K.-J., & Baltimore, D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605298103 · Cited by 4,317 · see citing works
A Mammalian microRNA Expression Atlas Based on Small RNA Library Sequencing
Landgraf, P., Rusu, M., Sheridan, R., Sewer, A., Iovino, N., Aravin, A., Pfeffer, S., Rice, A., Kamphorst, A. O., Landthaler, M., et al. (2007) · Cell · doi:10.1016/j.cell.2007.04.040 · Cited by 3,626 · see citing works
Grading the severity of chronic pain
Von Korff, M., Ormel, J., Keefe, F. J., & Dworkin, S. F. (1992) · Pain · doi:10.1016/0304-3959(92)90154-4 · Cited by 3,022 · see citing works
The prevention and treatment of missing data in clinical trials
Little, R. J., D'Agostino, R., Cohen, M. L., Dickersin, K., Emerson, S. S., Farrar, J. T., Frangakis, C., Hogan, J. W., Molenberghs, G., Murphy, S. A., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmsr1203730 · Cited by 1,884 · see citing works
Requirement of <i>bic/microRNA-155</i> for Normal Immune Function
Rodriguez, A., Vigorito, E., Clare, S., Warren, M. V., Couttet, P., Soond, D. R., van Dongen, S., Grocock, R. J., Das, P. P., Miska, E. A., et al. (2007) · Science · doi:10.1126/science.1139253 · Cited by 1,833 · see citing works
Regulation of the Germinal Center Response by MicroRNA-155
Thai, T., Calado, D. P., Casola, S. S., Ansel, K. M., Xiao, C., Xue, Y., Murphy, A. J., Frendewey, D. A., Valenzuela, D. M., Kutok, J. L., et al. (2007) · Science · doi:10.1126/science.1141229 · Cited by 1,477 · see citing works
Electrodiagnosis in Diseases of Nerve and Muscle: Principles and Practice
Kimura, J. (1983) · Cited by 1,474 · see citing works
Development and validation of the Neuropathic Pain Symptom Inventory
Bouhassira, D., Attal, N., Fermanian, J., Alchaar, H., Gautron, M., Masquelier, E., Rostaing, S., Lanteri-Minet, M., Collin, E., Grisart, J., et al. (2004) · Pain · doi:10.1016/j.pain.2003.12.024 · Cited by 1,329 · see citing works
microRNA Regulation of Inflammatory Responses
O’Connell, R. M., Rao, D. S., & Baltimore, D. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075013 · Cited by 957 · see citing works
Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis
Stańczyk, J., Pedrioli, D. M. L., Brentano, F., Sánchez‐Pernaute, O., Kolling, C., Gay, R. E., Detmar, M. J., Gay, S., & Kyburz, D. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23386 · Cited by 905 · see citing works
Deconstructing the Neuropathic Pain Phenotype to Reveal Neural Mechanisms
von Hehn, C. A., Baron, R., & Woolf, C. J. (2012) · Neuron · doi:10.1016/j.neuron.2012.02.008 · Cited by 804 · see citing works
RNA regulation: A new genetics?
Mattick, J. S. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1321 · Cited by 765 · see citing works
Pauley, K. M., Satoh, M., Chan, A. L., Bubb, M., Reeves, W. H., & Chan, E. K. L. (2008) · Arthritis Research & Therapy · doi:10.1186/ar2493 · Cited by 761 · see citing works
miR-155 gene: A typical multifunctional microRNA
Faraoni, I., Antonetti, F. R., Cardone, J., & Bonmassar, E. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.02.013 · Cited by 672 · see citing works
Löffler, D., Brocke-Heidrich, K., Pfeifer, G., Stocsits, C., Hackermüller, J., Kretzschmar, A. K., Burger, R., Gramatzki, M., Blumert, C., Bauer, K., et al. (2007) · Blood · doi:10.1182/blood-2007-03-081133 · Cited by 637 · see citing works
Hughes, R. A., Bensa, S., Willison, H. J., den Bergh, P. V., Comı, G., Illa, I., Nobile‐Orazio, E., van Doorn, P. A., Dalakas, M. C., Bojar, M., et al. (2001) · Annals of Neurology · doi:10.1002/ana.1088 · Cited by 631 · see citing works
Junker, A., Krumbholz, M., Eisele, S., Mohan, H., Augstein, F., Bittner, R., Lassmann, H., Wekerle, H., Hohlfeld, R., & Meinl, E. (2009) · Brain · doi:10.1093/brain/awp300 · Cited by 595 · see citing works
microRNAs and the immune response
Lindsay, M. A. (2008) · Trends in Immunology · doi:10.1016/j.it.2008.04.004 · Cited by 532 · see citing works
Turning 21: Induction of miR-21 as a Key Switch in the Inflammatory Response
Sheedy, F. J. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00019 · Cited by 496 · see citing works
Multifocal demyelinating neuropathy with persistent conduction block
Lewis, R. A., Sumner, A. J., Brown, M. J., & Asbury, A. K. (1982) · Neurology · doi:10.1212/wnl.32.9.958 · Cited by 492 · see citing works
The role of the immune system in the generation of neuropathic pain
Calvo, M., Dawes, J. M., & Bennett, D. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70134-5 · Cited by 447 · see citing works
Lacomis, D. (2002) · Muscle & Nerve · doi:10.1002/mus.10181 · Cited by 424 · see citing works
Electrodiagnosis in Diseases of Nerve and Muscle: Principles and Practice
Barkhaus, P. E. (2001) · Journal of Clinical Neuromuscular Disease · doi:10.1097/00131402-200112000-00010 · Cited by 408 · see citing works
Differential expression of cytokines in painful and painless neuropathies
Üçeyler, N., Rogausch, J. P., Toyka, K. V., & Sommer, C. (2007) · Neurology · doi:10.1212/01.wnl.0000265062.92340.a5 · Cited by 316 · see citing works
Self-citationmiR‐155: an ancient regulator of the immune system
Vigorito, E., Kohlhaas, S. L., Lu, D., & Leyland, R. (2013) · Immunological Reviews · doi:10.1111/imr.12057 · Cited by 294 · see citing works
The emerging roles of microRNAs in CNS injuries
Bhalala, O. G., Srikanth, M., & Kessler, J. A. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2013.67 · Cited by 274 · see citing works
MicroRNA-21 promotes Th17 differentiation and mediates experimental autoimmune encephalomyelitis
Murugaiyan, G., da Cunha, A. P., Ajay, A. K., Joller, N., Garo, L. P., Kumaradevan, S., Yosef, N., Vaidya, V. S., & Weiner, H. L. (2015) · Journal of Clinical Investigation · doi:10.1172/jci74347 · Cited by 239 · see citing works
MicroRNAs as biomarkers for CNS disease
Rao, P., Benito, E., & Fischer, A. (2013) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2013.00039 · Cited by 226 · see citing works
Role of miRNA-146a in the regulation of the innate immune response and cancer
Williams, A. E., Perry, M. M., Moschos, S. A., Larner-Svensson, H., & Lindsay, M. A. (2008) · Biochemical Society Transactions · doi:10.1042/bst0361211 · Cited by 226 · see citing works
MicroRNA-146a is linked to pain-related pathophysiology of osteoarthritis
Li, X., GIBSON, G. J., Kim, J., Kroin, J. S., Xu, S., van Wijnen, A. J., & Im, H. (2011) · Gene · doi:10.1016/j.gene.2011.03.003 · Cited by 210 · see citing works
Rebane, A., Runnel, T., Aab, A., Maslovskaja, J., Rückert, B., Zimmermann, M., Plaas, M., Kärner, J., Treis, A., Pihlap, M., et al. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.05.022 · Cited by 200 · see citing works
Superficial peroneal nerve/peroneus brevis muscle biopsy in vasculitic neuropathy
Collins, M. P., Mendell, J. R., Periquet, M. I., Sahenk, Z., Amato, A. A., Gronseth, G., Barohn, R. J., Jackson, C. E., & Kissel, J. T. (2000) · Neurology · doi:10.1212/wnl.55.5.636 · Cited by 199 · see citing works
MicroRNA-146a and Human Disease
Li, L., Chen, X.-P., & Li, Y.-J. (2010) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2010.02383.x · Cited by 193 · see citing works
NeurimmiRs: microRNAs in the neuroimmune interface
Soreq, H., & Wolf, Y. (2011) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2011.06.009 · Cited by 183 · see citing works
MicroRNAs as modulators and biomarkers of inflammatory and neuropathic pain conditions
Andersen, H. H., Duroux, M., & Gazerani, P. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.08.003 · Cited by 175 · see citing works
TNF-alpha expression in painful and nonpainful neuropathies
Empl, M., Renaud, S., Erne, B., Fuhr, P., Straube, A., Schaeren‐Wiemers, N., & Steck, A. (2001) · Neurology · doi:10.1212/wnl.56.10.1371 · Cited by 174 · see citing works
Axotomy-Induced miR-21 Promotes Axon Growth in Adult Dorsal Root Ganglion Neurons
Strickland, I. T., Richards, L. J., Holmes, F. E., Wynick, D., Uney, J. B., & Wong, L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023423 · Cited by 169 · see citing works
Cytokines in sural nerve biopsies from inflammatory and non-inflammatory neuropathies
Lindenlaub, T., & Sommer, C. (2003) · Acta Neuropathologica · doi:10.1007/s00401-003-0689-y · Cited by 165 · see citing works
Self-citationMicroRNA modulation in complex regional pain syndrome
Orlova, I. A., Alexander, G. M., Qureshi, R., Saçan, A., Graziano, A., Barrett, J. E., Schwartzman, R. J., & Ajit, S. K. (2011) · Journal of Translational Medicine · doi:10.1186/1479-5876-9-195 · Cited by 164 · see citing works
Differential Expression of MicroRNAs in Mouse Pain Models
Kusuda, R., Cadetti, F., Ravanelli, M. I. B., Sousa, T. A. E., Zanon, S., Lucca, F. L. D., & Lucas, G. (2011) · Molecular Pain · doi:10.1186/1744-8069-7-17 · Cited by 161 · see citing works
Signature of circulating microRNAs in osteoarthritis
Beyer, C., Zampetaki, A., Lin, N., Kleyer, A., Perricone, C., Iagnocco, A., Distler, A., Langley, S. R., Gelse, K., Sesselmann, S., et al. (2014) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2013-204698 · Cited by 158 · see citing works
Altered cytokine levels in the blood and cerebrospinal fluid of chronic pain patients
Backonja, M. “., Coe, C. L., Muller, D. A., & Schell, K. (2008) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.01.005 · Cited by 149 · see citing works
Aldrich, B. T., Frakes, E. P., Kasuya, J., Hammond, D. L., & Kitamoto, T. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.08.033 · Cited by 147 · see citing works
MicroRNA Dysregulation in the Spinal Cord following Traumatic Injury
Yunta, M., Nieto‐Díaz, M., Esteban, F. J., Caballero-López, M. J., Navarro-Ruíz, R., Reigada, D., Pita-Thomas, D. W., del Águila, Á., Muñoz‐Galdeano, T., & Maza, R. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034534 · Cited by 145 · see citing works
von Schack, D., Agostino, M. J., Murray, B. S., Li, Y., Reddy, P. S., Chen, J., Choe, S. E., Strassle, B. W., Li, C., Bates, B., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017670 · Cited by 144 · see citing works
Bai, G., Ambalavanar, R., Wei, D., & Dessem, D. (2007) · Molecular Pain · doi:10.1186/1744-8069-3-15 · Cited by 142 · see citing works
Mode of action of cytokines on nociceptive neurons
Üçeyler, N., Schäfers, M., & Sommer, C. (2009) · Experimental Brain Research · doi:10.1007/s00221-009-1755-z · Cited by 138 · see citing works
Self-citationMicroRNAs—novel regulators of systemic lupus erythematosus pathogenesis
Shen, N., Liang, D., Tang, Y., de Vries, N., & Tak, P. P. (2012) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2012.142 · Cited by 137 · see citing works
MiRNA in innate immune responses: novel players in wound inflammation
Roy, S., & Sen, C. K. (2010) · Physiological Genomics · doi:10.1152/physiolgenomics.00160.2010 · Cited by 127 · see citing works
The Role of MicroRNAs in Diabetic Complications—Special Emphasis on Wound Healing
Moura, J., Børsheim, E., & Carvalho, E. (2014) · Genes · doi:10.3390/genes5040926 · Cited by 125 · see citing works
MicroRNAs in brain development and function: a matter of flexibility and stability
Follert, P., Cremer, H., & Béclin, C. (2014) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2014.00005 · Cited by 124 · see citing works
(2005) · Elsevier eBooks · doi:10.1016/b978-0-7216-9491-7.x5001-7 · Cited by 116 · see citing works
Noncoding RNAs: key molecules in understanding and treating pain
Bali, K. K., & Kuner, R. (2014) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.05.006 · Cited by 114 · see citing works
MicroRNAs in rheumatoid arthritis
Ceribelli, A., Nahid, M. A., Satoh, M., & Chan, E. K. L. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.05.020 · Cited by 104 · see citing works
Imai, S., Saeki, M., Yanase, M., Horiuchi, H., Abe, M., Narita, M., Kuzumaki, N., Suzuki, T., & Narita, M. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0921-11.2011 · Cited by 97 · see citing works
Sakai, A., & Suzuki, H. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.04.089 · Cited by 97 · see citing works
Increased miR-132-3p expression is associated with chronic neuropathic pain
Leinders, M., Üçeyler, N., Pritchard, R. A., Sommer, C., & Sorkin, L. S. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.06.025 · Cited by 97 · see citing works
Self-citationmiRNA and mRNA expression analysis reveals potential sex-biased miRNA expression
Guo, L., Zhang, Q., Ma, X., Wang, J., & Liang, T. (2017) · Scientific Reports · doi:10.1038/srep39812 · Cited by 95 · see citing works
Suppression of MicroRNA-155 Attenuates Neuropathic Pain by Regulating SOCS1 Signalling Pathway
Tan, Y., Yang, J. H., Xiang, K., Tan, Q., & Guo, Q. (2014) · Neurochemical Research · doi:10.1007/s11064-014-1500-2 · Cited by 94 · see citing works
Serum MicroRNA Signatures in Migraineurs During Attacks and in Pain-Free Periods
Andersen, H. H., Duroux, M. C., & Gazerani, P. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9106-5 · Cited by 92 · see citing works
Elevated circulating miR-150 and miR-342-3p in patients with irritable bowel syndrome
Fourie, N. H., Peace, R. M., Abey, S. K., Sherwin, L. B., Rahim-Williams, B., Smyser, P. A., Wiley, J. W., & Henderson, W. A. (2014) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2014.04.009 · Cited by 91 · see citing works
Sommer, C., Richter, H., Rogausch, J. P., Frettlöh, J., Lungenhausen, M., & Maier, C. (2011) · BMC Neurology · doi:10.1186/1471-2377-11-104 · Cited by 90 · see citing works
Self-citationLi, X., Kroin, J. S., Kc, R., GIBSON, G. J., Chen, D., Corbett, G. T., Pahan, K., Fayyaz, S., Kim, J., van Wijnen, A. J., et al. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2002 · Cited by 86 · see citing works
Yu, B., Zhou, S., Wang, Y., Ding, G., Ding, F., & Gu, X. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024612 · Cited by 86 · see citing works
Ciccacci, C., Morganti, R., Fusco, D. D., D’Amato, C., Cacciotti, L., Greco, C., Rufini, S., Novelli, G., Sangiuolo, F. C., Marfia, G. A., et al. (2014) · Acta Diabetologica · doi:10.1007/s00592-014-0582-2 · Cited by 86 · see citing works
miR-155-3p Drives the Development of Autoimmune Demyelination by Regulation of Heat Shock Protein 40
Mycko, M. P., Cichalewska, M., Cwiklinska, H., & Selmaj, K. W. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.2830-15.2015 · Cited by 83 · see citing works
MicroRNA changes in the mouse prefrontal cortex after inflammatory pain
Pohl, K., Yeol, J., & Ongl, W. (2011) · European Journal of Pain · doi:10.1016/j.ejpain.2011.02.002 · Cited by 74 · see citing works
MicroRNA machinery responds to peripheral nerve lesion in an injury-regulated pattern
Wu, D., Raafat, M., Pak, E. S., Hammond, S., & Murashov, A. K. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.06.017 · Cited by 63 · see citing works
The Y in and Y ang of micro RNA s: leukemia and immunity
So, A. Y., Zhao, J. L., & Baltimore, D. (2013) · Immunological Reviews · doi:10.1111/imr.12043 · Cited by 57 · see citing works
Üçeyler, N., Riediger, N., Kafke, W., & Sommer, C. (2014) · Journal of Neurology · doi:10.1007/s00415-014-7556-8 · Cited by 56 · see citing works
Self-citationZhou, S., Zhang, S., Wang, Y., Yi, S., Zhao, L., Tang, X., Yu, B., Gu, X., & Ding, F. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.12.006 · Cited by 49 · see citing works
Douglas, S. R., Shenoda, B. B., Qureshi, R., Saçan, A., Alexander, G. M., Perreault, M. J., Barrett, J. E., Aradillas, E., Schwartzman, R. J., & Ajit, S. K. (2015) · Journal of Pain · doi:10.1016/j.jpain.2015.05.008 · Cited by 47 · see citing works
Jia, L., Wang, L., Chopp, M., Zhang, Y., Szalad, A., & Zhang, Z. G. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.05.005 · Cited by 47 · see citing works
Sakai, A., & Suzuki, H. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-22671-2_3 · Cited by 45 · see citing works
Progressive idiopathic axonal neuropathy
Notermans, N. C., Jansen, G. H., Wokke, J. H. J., Saïd, G., & Vrancken, A. F. J. E. (2004) · Journal of Neurology · doi:10.1007/s00415-004-0275-9 · Cited by 40 · see citing works
MicroRNAs in brain development and degeneration
Enciu, A., Popescu, B. O., & Gheorghisan-Galateanu, A. A. (2011) · Molecular Biology Reports · doi:10.1007/s11033-011-0973-1 · Cited by 37 · see citing works
Dynamic Change and Target Prediction of Axon-Specific MicroRNAs in Regenerating Sciatic Nerve
Phay, M., Kim, H. H., & Yoo, S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137461 · Cited by 31 · see citing works
Rau, C., Jeng, J. C., Jeng, S., Lu, T., Chen, Y., Liliang, P., Wu, C., Lin, C., & Hsieh, C. (2010) · BMC Musculoskeletal Disorders · doi:10.1186/1471-2474-11-181 · Cited by 30 · see citing works
Strickland, E. R., Woller, S. A., Hook, M. A., Grau, J. W., & Miranda, R. C. (2014) · Neurochemistry International · doi:10.1016/j.neuint.2014.05.005 · Cited by 21 · see citing works
Role of MicroRNA in Visceral Pain
Zhang, J., & Banerjee, B. (2015) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm15027 · Cited by 18 · see citing works
Strickland, E. R., Woller, S. A., Garraway, S. M., Hook, M. A., Grau, J. W., & Miranda, R. C. (2014) · Frontiers in Neural Circuits · doi:10.3389/fncir.2014.00117 · Cited by 18 · see citing works
Flagged first, then by citations
1 of the 82 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Inflammation in the pathophysiology of neuropathic pain
Sommer, C., Leinders, M., & Üçeyler, N. (2017) · Pain · doi:10.1097/j.pain.0000000000001122 · Cited by 496 · see citing works
Self-citationChiarelli, N., Ritelli, M., Zoppi, N., & Colombi, M. (2019) · Genes · doi:10.3390/genes10080609 · Cited by 82 · see citing works
Lie-xin, X., Ke, C., & Jing-min, L. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26526 · Cited by 74 · see citing works
Cutaneous Neuroimmune Interactions in Peripheral Neuropathic Pain States
Lowy, D. B., Makker, P. G. S., & Moalem‐Taylor, G. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.660203 · Cited by 69 · see citing works
Epigenetic and miRNA Expression Changes in People with Pain: A Systematic Review
Polli, A., Godderis, L., Ghosh, M., Ickmans, K., & Nijs, J. (2019) · Journal of Pain · doi:10.1016/j.jpain.2019.12.002 · Cited by 70 · see citing works
Emerging Roles of microRNAs as Biomarkers and Therapeutic Targets for Diabetic Neuropathy
Fan, B., Chopp, M., Zhang, Z. G., & Liu, X. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.558758 · Cited by 44 · see citing works
Polli, A., Ickmans, K., Godderis, L., & Nijs, J. (2018) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2018.09.118 · Cited by 44 · see citing works
Nerve and skin biopsy in neuropathies
Sommer, C. (2018) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000601 · Cited by 38 · see citing works
Self-citationCiccacci, C., Latini, A., Colantuono, A., Politi, C., D’Amato, C., Greco, C., Rinaldi, M. E., Lauro, D., Novelli, G., Spallone, V., et al. (2020) · Epigenomics · doi:10.2217/epi-2019-0242 · Cited by 39 · see citing works
Laliberté, A. M., Karadimas, S. K., Vidal, P. M., Satkunendrarajah, K., & Fehlings, M. G. (2021) · Brain Communications · doi:10.1093/braincomms/fcaa234 · Cited by 37 · see citing works
Bielska, A., Niemira, M., & Kretowski, A. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063153 · Cited by 37 · see citing works
The etiological roles of miRNAs , lncRNAs , and circRNAs in neuropathic pain: A narrative review
Jiang, M. H., Wang, Y., Wang, J., Feng, S., & Wang, X. (2022) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.24592 · Cited by 36 · see citing works
Toward Composite Pain Biomarkers of Neuropathic Pain—Focus on Peripheral Neuropathic Pain
Diaz, M. M., Caylor, J. R., Strigo, I. A., Lerman, I. R., Henry, B. L., López, E., Wallace, M. S., Ellis, R. J., Simmons, A. N., & Keltner, J. R. (2022) · Frontiers in Pain Research · doi:10.3389/fpain.2022.869215 · Cited by 35 · see citing works
New Vistas in microRNA Regulatory Interactome in Neuropathic Pain
Gada, Y., Pandey, A., Jadhav, N., Ajgaonkar, S., Mehta, D. S., & Nair, S. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.778014 · Cited by 34 · see citing works
Expression and Biological Functions of miRNAs in Chronic Pain: A Review on Human Studies
Sabina, S., Panìco, A., Mincarone, P., Leo, C. G., Garbarino, S., Grassi, T., Bagordo, F., Donno, A. D., Scoditti, E., & Tumolo, M. R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23116016 · Cited by 34 · see citing works
Dayer, C. F., Lüthi, F., Carré, J. L., Vuistiner, P., Terrier, P., Benaïm, C., Giacobino, J., & Léger, B. (2019) · PLoS ONE · doi:10.1371/journal.pone.0219311 · Cited by 29 · see citing works
Role of Micro-RNA for Pain After Surgery: Narrative Review of Animal and Human Studies
Cata, J. P., Görür, A., Yuan, X., Berg, N. K., Sood, A. K., & Eltzschig, H. K. (2020) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000004767 · Cited by 25 · see citing works
MicroRNA And Circular RNA Expression In Affected Skin Of Patients With Postherpetic Neuralgia
Cao, S., Zhang, D., Yuan, J., Liu, C., Zhou, W., Zhang, L., Yu, S., Qin, B., Li, Y., & Deng, W. (2019) · Journal of Pain Research · doi:10.2147/jpr.s221615 · Cited by 24 · see citing works
The Role of miRNAs in Neuropathic Pain
Morchio, M., Sher, E., Collier, D. A., Lambert, D., & Boissonade, F. M. (2023) · Biomedicines · doi:10.3390/biomedicines11030775 · Cited by 21 · see citing works
Reinhold, A., Yang, S., Chen, J. T.-C., Hu, L., Sauer, R., Krug, S. M., Mambretti, E. M., Fromm, M., Brack, A., & Rittner, H. L. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.01.008 · Cited by 21 · see citing works
What Is in the Field for Genetics and Epigenetics of Diabetic Neuropathy: The Role of MicroRNAs
Spallone, V., Ciccacci, C., Latini, A., & Borgiani, P. (2021) · Journal of Diabetes Research · doi:10.1155/2021/5593608 · Cited by 22 · see citing works
Reyes-Long, S., Cortes-Altamirano, J. L., Bandala, C., Avendaño-Ortiz, K., Bonilla‐Jaime, H., Bueno-Nava, A., Ávila-Luna, A., Sánchez-Aparicio, P., Clavijo‐Cornejo, D., Dotor-Llerena, A. L., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043574 · Cited by 20 · see citing works
Non-coding RNA regulators of diabetic polyneuropathy
Meydan, C., Üçeyler, N., & Soreq, H. (2020) · Neuroscience Letters · doi:10.1016/j.neulet.2020.135058 · Cited by 20 · see citing works
Self-citationJi, H., Lu, Y., liu, G., Zhao, X., Xu, M., & Chen, M. (2024) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s467409 · Cited by 19 · see citing works
Reinhold, A., Krug, S. M., Salvador, E., Sauer, R. S., Karl‐Schöller, F., Malcangio, M., Sommer, C., & Rittner, H. L. (2022) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14816 · Cited by 19 · see citing works
Self-citationPoly(Lactic-Co-Glycolic Acid) Nanomaterial-Based Treatment Options for Pain Management: A Review
Phạm, T. L., & Kim, D. W. (2020) · Nanomedicine · doi:10.2217/nnm-2020-0114 · Cited by 19 · see citing works
Karl‐Schöller, F., Kunz, M., Kreß, L., Held, M., Egenolf, N., Wiesner, A., Dandekar, T., Sommer, C., & Üçeyler, N. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113915 · Cited by 19 · see citing works
Self-citationmiRNA contributes to neuropathic pains
Vali, R., Azadi, A., Tizno, A., Farkhondeh, T., Samini, F., & Samarghandian, S. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.126893 · Cited by 18 · see citing works
Exosome-mediated miRNA delivery: a molecular switch for reshaping neuropathic pain therapy
Wei, Z., Guo, C., Zhou, H., Wu, Y., Zhou, X., Chen, J., & Li, F. (2025) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2025.1625943 · Cited by 17 · see citing works
Systemic inflammatory markers in patients with polyneuropathies
García-Fernández, P., Höfflin, K., Rausch, A., Strommer, K., Neumann, A., Cebulla, N., Reinhold, A., Rittner, H. L., Üçeyler, N., & Sommer, C. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1067714 · Cited by 16 · see citing works
Self-citationGlobal research trends on epigenetics and neuropathic pain: A bibliometric analysis
Zhu, C., Zhong, W., Gong, C., Chen, B., & Guo, J. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1145393 · Cited by 14 · see citing works
Local Inflammatory Mediators Involved in Neuropathic Pain
García-Fernández, P., Reinhold, C., Üçeyler, N., & Sommer, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24097814 · Cited by 14 · see citing works
Self-citationPolyphenols target miRNAs as a therapeutic strategy for diabetic complications
Malakoti, F., Mohammadi, E., Oryani, M. A., Shanebandi, D., Yousefi, B., Salehi, A., & Asemi, Z. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2119364 · Cited by 14 · see citing works
Sun, X., Zhang, Y., Zhenqin, L., Li, S., & Wang, L. (2021) · Molecular Biotechnology · doi:10.1007/s12033-021-00323-w · Cited by 13 · see citing works
Giordano, R., Petersen, K. K., Santoro, M., Pazzaglia, C., Simonsen, O. H., Valeriani, M., & Arendt‐Nielsen, L. (2021) · Scandinavian Journal of Pain · doi:10.1515/sjpain-2021-0069 · Cited by 12 · see citing works
Roganović, J., & Petrović, N. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158278 · Cited by 12 · see citing works
Macrophage to neuron communication via extracellular vesicles in neuropathic pain conditions
Picco, F., Zeboudj, L., Oggero, S., Prato, V., Burgoyne, T., Gamper, N. L., & Malcangio, M. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e41268 · Cited by 11 · see citing works
Mechanisms of exercise for diabetic neuropathic pain
Luo, J., Zhu, H.-Q., Gou, B., & Zheng, Y.-L. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.975453 · Cited by 13 · see citing works
Integrative miRNA–mRNA profiling of human epidermis: unique signature of SCN9A painful neuropathy
Anđelić, M., Salvi, E., Marcuzzo, S., Marchi, M., Lombardi, R., Cartelli, D., Cazzato, D., Mehmeti, E., Gelemanović, A., Paolini, M., et al. (2023) · Brain · doi:10.1093/brain/awad025 · Cited by 10 · see citing works
Therapeutic Implication of miRNAs as an Active Regulatory Player in the Management of Pain: A Review
Hassan, M., Shahzadi, S., Yasir, M., Chun, W., & Kloczkowski, A. (2024) · Genes · doi:10.3390/genes15081003 · Cited by 8 · see citing works
Pellegrino, A., Fabig, S., Kersebaum, D., Hüllemann, P., Baron, R., Roch, T., Babel, N., & Seitz, H. (2023) · Biomedicines · doi:10.3390/biomedicines11030764 · Cited by 7 · see citing works
Fekry, E., Refaat, G., & Hosny, S. A. (2025) · Microscopy and Microanalysis · doi:10.1093/mam/ozaf002 · Cited by 5 · see citing works
The temporal expression of circulating microRNAs after acute experimental pain in humans
Giordano, R., Gerra, M. C., Okutani, H., Vecchio, S. L., Stensballe, A., Petersen, K. K., & Arendt‐Nielsen, L. (2022) · European Journal of Pain · doi:10.1002/ejp.2062 · Cited by 5 · see citing works
Qin, L., Liao, J., Tan, C., Liu, C., Shi, W., & Chen, D. (2025) · Biomedicines · doi:10.3390/biomedicines13102456 · Cited by 4 · see citing works
Acarlı, A. N. Ö., Tüzün, E., Şanlı, E., Koral, G., Akbayır, E., Çakar, A., Şi̇ri̇n, N. G., Soysal, A., Aysal, F., Durmuş, H., et al. (2023) · Clinical & Experimental Immunology · doi:10.1093/cei/uxad103 · Cited by 4 · see citing works
MicroRNAs in diabetes mellitus
Ali, P. S. S., Ahmad, M. P., & Parveen, K. M. H. (2025) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-025-01591-y · Cited by 3 · see citing works
Pawlina‐Tyszko, K., Oczkowicz, M., Gurgul, A., Szmatoła, T., & Bugno‐Poniewierska, M. (2020) · Biology of Sex Differences · doi:10.1186/s13293-020-00343-2 · Cited by 2 · see citing works
Gummadi, S. A., Ju, R. R., Pastor, V., Meyers, E., Rozen, S. M., & Tavares‐Ferreira, D. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.15.699768 · Cited by 2 · see citing works
Zhou, X., Guo, G., Yu, S., & Hu, R. (2024) · PubMed Central · doi:10.11817/j.issn.1672-7347.2024.230273 · Cited by 1 · see citing works
Fathy, W., Hussein, M., Magdy, R., Nasser, M., Mohamed, J., Sayem, D. M., Mahmoud, H. E., Mounir, N., Fakhry, D. M., & Abdelbadie, M. (2025) · Anesthesiology Research and Practice · doi:10.1155/anrp/2201031 · Cited by 1 · see citing works
Neuropathic Pain: Mechanisms, Clinical Aspects and Treatment Options
Kersebaum, D., Sachau, J., Fabig, S., & Baron, R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.24257-0 · Cited by 1 · see citing works
Mkumbuzi, N. S., Posthumus, M., September, A. V., & Collins, M. (2021) · Central European Journal of Sport Sciences and Medicine · doi:10.18276/cej.2021.4-06
Noncoding RNAs Are New Players in Chronic Pain
Wu, S., & Tao, Y. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814070-3.00009-0
Han, J., Zhao, X., Jiang, R., Jiang, C., Li, L., Xu, Z., Song, Y., & Feng, X. (2022) · Research Square · doi:10.21203/rs.3.rs-1963908/v1
华, 季., Lu, Y., Liu, G., Zhao, X., Xu, M., & Chen, M. (2024) · Research Square · doi:10.21203/rs.3.rs-3969442/v1
Tatikola, S. P., Venkatesh, N., Desai, V. K., & Asirvatham, A. R. (2025) · Journal of Endocrinology & Reproduction · doi:10.18311/jer/2024/45389
Muratori, L., Rando, S., & Raimondo, S. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27188234
- Authors
- Leinders, M., Üçeyler, N., Thomann, A., & Sommer, C.
- Affiliations
- University of Würzburg (DE)
- Corresponding author
- Leinders, Mathias
- Venue
- Journal of the Neurological Sciences
- Publisher
- Elsevier BV
- Published
- 2017-09
- Volume
- 380
- Pages
- 242-249
- ISSN
- 0022-510X (ISSN-L)
- OpenAlex
- W2741097995
- Cited by
- 57
- References
- 82
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 5 · 2023: 9 · 2022: 10 · 2021: 8 · 2020: 7 · 2019: 5 · 2018: 4 · 2017: 1
- FWCI
- 3.45
- Type
- journal article
- Language
- en
- Open access
- green
- zenodo.org
- Licence
- Locations
- Journal of the Neurological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
- Funders
- Deutsche Forschungsgemeinschaft
- Seventh Framework Programme (602133)
- Julius-Maximilians-Universität Würzburg
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Keywords
- microRNA expression, peripheral neuropathy, neuropathic pain, miR-21, miR-146a, miR-155, leukocytes, sural nerve, skin biopsy, inflammation, polyneuropathy
- MeSH terms
- Adult, Aged, Aged, 80 and over, Biopsy, Female, Gene Expression Regulation, Humans, Male, Middle Aged, Pain, Pain Measurement, Peripheral Nervous System Diseases, Severity of Illness Index, Sural Nerve, Cohort Studies, Cytokines, Statistics, Nonparametric, MicroRNAs
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