Cited by 191Down syndrome and intellectual disability researchGenetics and Neurodevelopmental DisordersWilliams Syndrome Research

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Down's syndrome: Is there a decreased population of neurons?

Ross, Majorie H., Galaburda, Albert M., Kemper, Thomas L.·1984·Neurology

DOI 10.1212/wnl.34.7.909

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Abstract

Although gross abnormalities have been described in the brains of patients with Down's syndrome (DS), microscopic studies have revealed only minor and inconsistent findings. We compared two DS brains, in whole-brain serial sections, with similarly prepared age- and sex-matched normal controls. Architectonic abnormalities were noted, and cell counts revealed a significant poverty of granular cells in the DS brains, particularly in granular fields such as areas 3, 17, and 41. Golgi studies demonstrated all major cell types. A striking feature of the brain morphology in DS may be the curtailment of a specific cell type, most likely the aspinous stellate.

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Authors: Ross, M. H., Galaburda, A. M., & Kemper, T. L.
Affiliations: Boston University (US)
Venue: Neurology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1984-07
Volume: 34
Issue: 7
Pages: 909-909
ISSN: 0028-3878 (ISSN-L)
1526-632X
DOI: 10.1212/wnl.34.7.909
OpenAlex: W2054562862
Cited by: 191
References: 0
Citations by year: 2025: 5 · 2024: 4 · 2023: 5 · 2022: 9 · 2021: 4 · 2020: 2 · 2019: 5 · 2018: 6 · 2017: 7 · 2016: 2 · 2015: 5 · 2014: 3 · 2013: 2 · 2012: 2
FWCI: 12.82
Type: journal article
Language: en
Open access: closed
Locations: Neurology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Life Sciences › Neuroscience › Developmental Neuroscience › Williams Syndrome Research
Keywords: Down syndrome, brain architecture, neuronal cell counts, granular cells, brain structure, Golgi staining, cerebral cortex
MeSH terms: Adult, Auditory Cortex, Brain, Child, Down Syndrome, Female, Humans, Male, Somatosensory Cortex, Visual Cortex

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Down's syndrome: Is there a decreased population of neurons?

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