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MPTP: A neurotoxin relevant to the pathophysiology of Parkinson's disease: The 1985 George C. Cotzias Lecture
Abstract
MPTP (N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) elicits selective destruction of nigrostriatal dopamine neurons in humans and animals along with clinical symptoms of parkinsonism. Recent studies clarify mechanisms accounting for this neurotoxicity. MPTP binds with high affinity to monoamine oxidase, which transforms it to the pyridinium MPP+ . MPP+ is selectively concentrated by the dopamine neuronal uptake system. In nigral cells, binding by melanin of MPP+ affords a "depot" release mechanism to maintain prolonged high intracellular concentrations sufficient to destroy cells. PC-12 cells provide a model catecholamine cell culture for screening environmentally occurring substances that may be relevant in the etiology of idiopathic Parkinson's disease.
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Vandenbergh, D. J., Persico, A. M., Hawkins, A. L., Griffin, C. A., Li, X., Jabs, E. W., & Uhl, G. R. (1992) · Genomics · doi:10.1016/s0888-7543(05)80138-7 · Cited by 708
Vesicular monoamine transporter 2: Role as a novel target for drug development
Zheng, G., Dwoskin, L. P., & Crooks, P. A. (2006) · The AAPS Journal · doi:10.1208/aapsj080478 · Cited by 125
Masilamoni, G. J., Groover, O., & Smith, Y. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.12.025 · Cited by 37
Metadata
- Authors
- Snyder, S. H., & D'Amato, R. J.
- Venue
- Neurology
- Published
- 1986-02
- Volume
- 36
- Issue
- 2
- Pages
- 250-250
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2063985177
- Cited by
- 294
- References
- 0
- FWCI
- 31.64
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: MPTP: A neurotoxin relevant to the pathophysiology of Parkinson's disease: The 1985 George C. Cotzias Lecture. https://app.cochat.ai/papers/10.1212/wnl.36.2.250
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- Snyder, S. H., & D'Amato, R. J. (1986). MPTP: A neurotoxin relevant to the pathophysiology of Parkinson's disease: The 1985 George C. Cotzias Lecture. Neurology. https://doi.org/10.1212/wnl.36.2.250
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
