Orthostatic hypotension as a risk factor for symptomatic occlusive cerebrovascular disease
Abstract
Thirteen patients presented with brief, repetitive, stereotyped transient ischemic attacks, large artery atherostenoses or occlusions with impaired collateral flow to a cortical perfusion borderzone, and orthostatic hypotension (OH). OH was caused by diabetes mellitus, aging, and treatments for ischemic heart disease and hypertension. Medical management of OH often eliminated the need for stroke prevention measures such as surgery or anticoagulation. Focal cerebral hypoperfusion from the combination of occlusive vascular disease and OH may be an underreported, treatable cause of TIA and stroke.
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Orthostatic TIAs concern a combination of multiple stenoses of cerebral arteries and OH, and may rarely result in repetitive, orthostatic, short-lasting, and stereotyped TIAs.
“An exception concerns orthostatic TIAs , concerning a combination of multiple stenoses of cerebral arteries and OH. This may rarely result in repetitive, orthostatic, short-lasting, and stereotyped TIAs.”
From 2018 ESC Guidelines for the diagnosis and management of syncope (2018) · cites this paper as [424]
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“This may rarely result in repetitive, orthostatic, short-lasting, and stereotyped TIAs.(423,424) A TIA of the vertebrobasilar system can cause LOC, but there are always focal signs, usually limb weakness, gait and limb ataxia, vertigo, diplopia, nystagmus, dysarthria, and oropharyngeal dysfunction.”
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- Authors
- Dobkin, B. H.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Dobkin, Bruce H.
- ORCID
- Dobkin, Bruce H.
- Venue
- Neurology
- Published
- 1989-01
- Volume
- 39
- Issue
- 1
- Pages
- 30-30
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2075153221
- Cited by
- 95
- References
- 0
- Citations by year
- 2024: 2 · 2023: 1 · 2022: 1 · 2020: 2 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 5 · 2013: 3 · 2012: 1
- FWCI
- 6.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cerebrovascular and Carotid Artery Diseases
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Keywords
- orthostatic hypotension, transient ischemic attack, stroke, cerebral ischemia, large artery atherosclerosis, collateral circulation, diabetes mellitus, stroke prevention, antihypertensive drugs
- MeSH terms
- Arterial Occlusive Diseases, Carotid Artery Diseases, Cerebral Angiography, Ischemic Attack, Transient, Cerebrovascular Disorders, Constriction, Pathologic, Female, Humans, Hypotension, Orthostatic, Middle Aged, Risk Factors, Tomography, X-Ray Computed, Diabetes Complications
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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