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Cerebrospinal fluid production is reduced in healthy aging
Abstract
In order to study age-related differences in cerebrospinal fluid (CSF) production in humans, we measured the rate of CSF production in 7 young (age 21 to 36 years) and 7 elderly (age 67 to 84 years) healthy volunteers, using a modified Masserman method. In addition, we evaluated CSF protein gradients by collecting CSF in serial fractions up to the 30th ml and assaying for total protein concentration. The mean rate of CSF production was significantly less in the elderly than in the young subjects. Mean CSF total protein concentrations were higher in the elderly than in the young, and significant rostrocaudal protein gradients with similar slopes were present in both groups. However, there was no correlation between CSF production and CSF total protein concentrations or protein gradient slopes. Age-related reductions in CSF production, together with the ventricular dilatation that occurs with aging, should presumably result in reduced CSF turnover and therefore influence measured concentrations of lumbar CSF constituents.
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Cited by
Impairment of paravascular clearance pathways in the aging brain
Kress, B. T., Iliff, J. J., Xia, M., Wang, M., Wei, H. S., Zeppenfeld, D., Xie, L., Kang, H., Xu, Q., Liew, J. A., et al. (2014) · Annals of Neurology · doi:10.1002/ana.24271 · Cited by 1,521
“This finding may also help to explain the observation that CSF turnover decreases and CSF protein concentrations increase in the aging brain.(37) A substantial fraction of subarachnoid CSF recirculates through the brain parenchyma along paravascular pathways, and AQP4-dependent fluid movement along these pathways is a…”
BackgroundCerebrospinal fluid analysis: disease-related data patterns and evaluation programs
Reiber, H., & Peter, J. B. (2001) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(00)00501-3 · Cited by 731
Ma, Q., Ineichen, B. V., Detmar, M., & Proulx, S. T. (2017) · Nature Communications · doi:10.1038/s41467-017-01484-6 · Cited by 690
Dynamics of brain-derived proteins in cerebrospinal fluid
Reiber, H. (2001) · Clinica Chimica Acta · doi:10.1016/s0009-8981(01)00573-3 · Cited by 516
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Da Mesquita, S., Fu, Z., & Kipnis, J. (2018) · Neuron · doi:10.1016/j.neuron.2018.09.022 · Cited by 479
Metadata
- Authors
- May, C., Kaye, J. A., Atack, J. R., Schapiro, M. B., Friedland, R. P., & Rapoport, S. I.
- Venue
- Neurology
- Published
- 1990-03
- Volume
- 40
- Issue
- 3_part_1
- Pages
- 500-500
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2143795852
- Cited by
- 315
- References
- 0
- FWCI
- 0.68
- Type
- journal article
- Language
- en
- Open access
- closed
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- May, C., Kaye, J. A., Atack, J. R., Schapiro, M. B., Friedland, R. P., & Rapoport, S. I. (1990). Cerebrospinal fluid production is reduced in healthy aging. Neurology. https://doi.org/10.1212/wnl.40.3_part_1.500
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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