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Both intravenous lidocaine and morphine reduce the pain of postherpetic neuralgia
Abstract
We studied the analgesic efficacy of an intravenous infusion of lidocaine and morphine in 19 adults with well-established postherpetic neuralgia in a three-session, randomized, double-blind, placebo-controlled trial. Compared with saline placebo, both lidocaine and morphine reduced pain intensity. Reductions in pain did not correlate with side effects produced by the infusions. For morphine, there was a significant correlation between reductions in pain intensity and blood level achieved. In the majority of subjects who reported definite pain relief, allodynia also disappeared. The results show that neuropathic pain can respond to opioids and to systemically administered local anesthetic drugs.
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Citations
Cited by
Opioids in chronic non-cancer pain: systematic review of efficacy and safety
Kalso, E., Edwards, J. E., Moore, A. R., & McQuay, H. J. (2004) · Pain · doi:10.1016/j.pain.2004.09.019 · Cited by 1,216
Postherpetic Neuralgia — Pathogenesis, Treatment, and Prevention
Kost, R. G., & Straus, S. E. (1996) · New England Journal of Medicine · doi:10.1056/nejm199607043350107 · Cited by 641
Postherpetic Neuralgia: Irritable Nociceptors and Deafferentation
Fields, H. L., Rowbotham, M., & Baron, R. (1998) · Neurobiology of Disease · doi:10.1006/nbdi.1998.0204 · Cited by 561
Self-citationComplex Regional Pain Syndromes: Guidelines for Therapy
Stanton-Hicks, M., Baron, R., Boas, R., Gordh, T., Harden, N., Hendler, N., Koltzenburg, M., Raj, P., & Wilder, R. (1998) · The Clinical Journal of Pain · doi:10.1097/00002508-199806000-00012 · Cited by 378
Systemic lidocaine for neuropathic pain relief
Mao, J., & Chen, L. L. (2000) · Pain · doi:10.1016/s0304-3959(00)00229-3 · Cited by 375
Metadata
- Authors
- Rowbotham, M. C., Reisner-Keller, L. A., & Fields, H. L.
- Venue
- Neurology
- Published
- 1991-07
- Volume
- 41
- Issue
- 7
- Pages
- 1024-1024
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2031115386
- Cited by
- 477
- References
- 0
- FWCI
- 5.85
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Both intravenous lidocaine and morphine reduce the pain of postherpetic neuralgia. https://app.cochat.ai/papers/10.1212/wnl.41.7.1024
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- Rowbotham, M. C., Reisner-Keller, L. A., & Fields, H. L. (1991). Both intravenous lidocaine and morphine reduce the pain of postherpetic neuralgia. Neurology. https://doi.org/10.1212/wnl.41.7.1024
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
