The DOI matches its Crossref record.
Surgical treatment of cervical spondylotic myelopathy: Time for a controlled trial
Abstract
Surgical procedures on the cervical spine are accepted therapies for the myelopathy of cervical spondylosis. However, reported improvement rates vary widely, and many reports indicate improvement in about one-half of the cases. It has not been proven that outcome after surgery is better than the natural history or conservative therapy. Radiographic or imaging evidence of cord impingement or compression may be seen in asymptomatic people. There are no clear guides to the selection of patients who may benefit from the operation and there has been no standardization of preoperative evaluation, trials of conservative therapy, ascertainment of progressive disability, or assessment of outcome. A multicenter controlled trial might answer these questions.
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“Results from recent studies assessing the impact of aging on hippocampal and other temporal lobe structures have been variable. Some have found age-related declines in volume in normal elderly individuals [4, 30, 31] while others have not [3, 32].”
From Rate of medial temporal lobe atrophy in typical aging and Alzheimer's disease (1998) · cites this paper as [30]
In the citing paper
“Coffey et al [30] estimated a rate of volume loss of the amygdala/hippocampus of 0.3%/year.”
From Rate of medial temporal lobe atrophy in typical aging and Alzheimer's disease (1998) · cites this paper as [30]
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Medial temporal atrophy on MRI in normal aging and very mild Alzheimer's disease
Jack, C. R., Petersen, R. C., Xu, Y. C., Waring, S. C., O'Brien, P. C., Tangalos, E. G., Smith, G. E., Ivnik, R. J., & Kokmen, E. (1997) · Neurology · doi:10.1212/wnl.49.3.786 · Cited by 1,128
Rate of medial temporal lobe atrophy in typical aging and Alzheimer's disease
Jack, C. R., Petersen, R. C., Xu, Y., O'Brien, P. C., Smith, G. E., Ivnik, R. J., Tangalos, E. G., & Kokmen, E. (1998) · Neurology · doi:10.1212/wnl.51.4.993 · Cited by 666
Lucchinetti, C. F., Kimmel, D. W., & Lennon, V. A. (1998) · Neurology · doi:10.1212/wnl.50.3.652 · Cited by 499
Oxidative stress: Free radical production in neural degeneration
Götz, M. E., Künig, G., Riederer, P. F., & Youdim, M. B. H. (1994) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(94)90055-8 · Cited by 482
White matter changes with normal aging.
Guttmann, C. R. G., Jolesz, F. A., Kikinis, R., Killiany, R. J., Moss, M. B., Sandor, T., & Albert, M. S. (1998) · Neurology · doi:10.1212/wnl.50.4.972 · Cited by 466
Metadata
- Authors
- Rowland, L. P.
- Affiliations
- NewYork–Presbyterian Hospital (US)
- Corresponding author
- Rowland, Lewis P.
- Venue
- Neurology
- Published
- 1992-01
- Volume
- 42
- Issue
- 1
- Pages
- 5-5
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2048057683
- Cited by
- 157
- References
- 0
- Citations by year
- 2026: 3 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 4 · 2016: 4 · 2015: 1 · 2014: 5 · 2013: 5 · 2012: 3
- FWCI
- 7.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service (GCRC-00645)
- National Institute of Neurological Disorders and Stroke (NS-11766)
- Topics
- Health Sciences › Medicine › Surgery › Cervical and Thoracic Myelopathy
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Spine and Intervertebral Disc Pathology
- Keywords
- cervical spondylotic myelopathy, cervical spondylosis, cervical spine surgery, surgical outcomes, conservative treatment, patient selection, preoperative assessment, spinal cord compression, natural history (disease), disability progression
- MeSH terms
- Animals, Humans, Levodopa, Neurology, Parkinson Disease, Parkinson Disease, Secondary, Selegiline, MPTP Poisoning
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