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Acute quadriplegic myopathy: A complication of treatment with steroids, nondepolarizing blocking agents, or both
Abstract
We studied two patients who were given high-dose intravenous steroid therapy and were intubated for status asthmaticus. Both became quadriplegic and wasted within 2 weeks. EMG had myopathic abnormalities. Muscle biopsy revealed severe atrophy of most muscle fibers, with disorganization of myofibrils and selective loss of thick (myosin) filaments. Immunohistologic stains for myosin isoforms confirmed the decrease or absence of this protein. Both patients clinically improved over several months.
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Cited by
A framework for diagnosing and classifying intensive care unit-acquired weakness
Stevens, R. D., Marshall, S. A., Cornblath, D. R., Hoke, A., Needham, D. M., de Jonghe, B., Ali, N. A., & Sharshar, T. (2009) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181b6ef67 · Cited by 698
Neuromuscular manifestations of critical illness
Bolton, C. F. (2005) · Muscle & Nerve · doi:10.1002/mus.20304 · Cited by 411
The Sick and the Weak: Neuropathies/Myopathies in the Critically Ill
Friedrich, O., Reid, M. B., Van den Berghe, G., Vanhorebeek, I., Hermans, G., Rich, M. M., & Larsson, L. (2015) · Physiological Reviews · doi:10.1152/physrev.00028.2014 · Cited by 396
Implications of glucocorticoid therapy in idiopathic inflammatory myopathies
Hanaoka, B. Y., Peterson, C. A., Horbinski, C., & Crofford, L. J. (2012) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2012.85 · Cited by 57
Andersen (2000) · doi:10.1002/1097-4598(200007)23:7<1095::aid-mus13>3.0.co;2-o
Metadata
- Authors
- Hirano, M., Ott, B. R., Raps, E. C., Minetti, C., Lennihan, L., Libbey, N. P., Bonilla, E., & Hays, A. P.
- Venue
- Neurology
- Published
- 1992-11
- Volume
- 42
- Issue
- 11
- Pages
- 2082-2082
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2155813406
- Cited by
- 220
- References
- 0
- FWCI
- 3.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Acute quadriplegic myopathy: A complication of treatment with steroids, nondepolarizing blocking agents, or both. https://app.cochat.ai/papers/10.1212/wnl.42.11.2082
- The paper
- Hirano, M., Ott, B. R., Raps, E. C., Minetti, C., Lennihan, L., Libbey, N. P., Bonilla, E., & Hays, A. P. (1992). Acute quadriplegic myopathy: A complication of treatment with steroids, nondepolarizing blocking agents, or both. Neurology. https://doi.org/10.1212/wnl.42.11.2082
Data sources
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
