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Pick's disease versus Alzheimer's disease: A comparison of clinical characteristics
Abstract
The clinical recognition of Pick's disease depends on its differentiation from Alzheimer's disease (AD). To identify distinguishing clinical features, we reviewed the clinical records of 21 patients with pathologically confirmed Pick's disease and matched them by sex, age of onset, and duration of dementia with 42 patients having pathologically confirmed AD. In the absence of temporal or frontal lobar atrophy on CTs, all the Pick patients and none of the AD patients had three of five clinical features: presenile onset (before age 65), an initial personality change, hyperorality, disinhibition, and roaming behavior. In addition, the Pick patients had a tendency toward reiterative and other speech disturbances. These findings suggest that Pick patients are potentially distinguishable from AD patients on the basis of clinical manifestations.
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Cited by
Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia
Rascovsky, K., Hodges, J. R., Knopman, D., Mendez, M. F., Kramer, J. H., Neuhaus, J., van Swieten, J. C., Seelaar, H., Dopper, E. G. P., Onyike, C. U., et al. (2011) · Brain · doi:10.1093/brain/awr179 · Cited by 5,221
Self-citationFDG-PET improves accuracy in distinguishing frontotemporal dementia and Alzheimer's disease
Foster, N. L., Heidebrink, J. L., Clark, C. M., Jagust, W. J., Arnold, S. E., Barbas, N. R., DeCarli, C. S., Scott Turner, R., Koeppe, R. A., Higdon, R., et al. (2007) · Brain · doi:10.1093/brain/awm177 · Cited by 608
The frontal behavioral inventory in the differential diagnosis of frontotemporal dementia
KERTESZ, A., NADKARNI, N., DAVIDSON, W., & THOMAS, A. W. (2000) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617700644041 · Cited by 317
Rascovsky, K., Hodges, J. R., Kipps, C. M., Johnson, J. K., Seeley, W. W., Mendez, M. F., Knopman, D., Kertesz, A., Mesulam, M., Salmon, D. P., et al. (2007) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e31815c3445 · Cited by 260
Self-citationVarma, A. R., Snowden, J. S., Lloyd, J. J., Talbot, P. R., Mann, D. M. A., & Neary, D. (1999) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.66.2.184 · Cited by 238
Metadata
- Authors
- Mendez, M. F., Selwood, A., Mastri, A. R., & Frey, W. H.
- Venue
- Neurology
- Published
- 1993-02
- Volume
- 43
- Issue
- 2
- Pages
- 289-289
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2057926072
- Cited by
- 184
- References
- 0
- FWCI
- 4.93
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Pick's disease versus Alzheimer's disease: A comparison of clinical characteristics. https://app.cochat.ai/papers/10.1212/wnl.43.2.289
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- Mendez, M. F., Selwood, A., Mastri, A. R., & Frey, W. H. (1993). Pick's disease versus Alzheimer's disease: A comparison of clinical characteristics. Neurology. https://doi.org/10.1212/wnl.43.2.289
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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