The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Relationship between cigarette smoking and Alzheimer's disease in a population‐based case‐control study
Abstract
We investigated whether cigarette smoking is negatively associated with Alzheimer's disease (AD) in a population-based, frequency-matched, case-control study of 152 AD patients and 180 controls. Ever having smoked was associated with lower risk of AD (adjusted odds ratio = 0.61; 95% confidence interval: 0.37-0.99). Additional multivariate analyses demonstrated that education and history of hypertension modified this association. The direction of the modification was for higher education level and history of hypertension to further reduce the risk. The "dose-response" pattern showed the greatest risk reduction among those who smoked least and suggests a biologic mechanism of a dose-dependent up-regulation of nicotinic (cholinergic) brain receptors. These data, although consistent with current opinion about pathophysiology of AD, do not suggest smoking should be used as a preventive strategy for AD.
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Cites
Synaptic loss in Alzheimer's disease and other dementias
Hamos, J. E., DeGennaro, L. J., & Drachman, D. A. (1989) · Neurology · doi:10.1212/wnl.39.3.355 · Cited by 432
Cited by
15-year longitudinal study of blood pressure and dementia
Skoog, I., Nilsson, L., Persson, G., Lernfelt, B., Landahl, S., Palmertz, B., Andreasson, L.-A., Odén, A., & Svanborg, A. (1996) · The Lancet · doi:10.1016/s0140-6736(96)90608-x · Cited by 1,726
Epidemiology of Alzheimer disease
Reitz, C., Brayne, C., & Mayeux, R. (2011) · Nature Reviews Neurology · doi:10.1038/nrneurol.2011.2 · Cited by 1,675
Levin, E. D., McClernon, F. J., & Rezvani, A. H. (2006) · Psychopharmacology · doi:10.1007/s00213-005-0164-7 · Cited by 820
Rates and risk factors for dementia and Alzheimer’s disease: Results from EURODEM pooled analyses
Launer, L. J., Andersen, K., Dewey, M. E., Letenneur, L., Ott, A., Amaducci, L. A., Brayne, C., Copeland, J. R. M., Dartigues, J.-F., Kragh-Sorensen, P., et al. (1999) · Neurology · doi:10.1212/wnl.52.1.78 · Cited by 758
Nicotinic acetylcholine involvement in cognitive function in animals
Levin, E. D., & Simon, B. B. (1998) · Psychopharmacology · doi:10.1007/s002130050667 · Cited by 678
Metadata
- Authors
- Brenner, D. E., Kukull, W. A., van Belle, G., Bowen, J. D., McCormick, W. C., Teri, L., & Larson, E. B.
- Venue
- Neurology
- Published
- 1993-02
- Volume
- 43
- Issue
- 2
- Pages
- 293-293
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W1973346209
- Cited by
- 183
- References
- 1
- FWCI
- 8.63
- Type
- journal article
- Language
- en
- Open access
- closed
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- Brenner, D. E., Kukull, W. A., van Belle, G., Bowen, J. D., McCormick, W. C., Teri, L., & Larson, E. B. (1993). Relationship between cigarette smoking and Alzheimer's disease in a population‐based case‐control study. Neurology. https://doi.org/10.1212/wnl.43.2.293
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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